- Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells
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Kim C, Ryu HC, Kim JH
- KMID: 1115267
- Exp Mol Med.
- 2010 Dec;42(12):833-841.
- doi: 10.3858/emm.2010.42.12.086
Skin exposure to low-dose ultraviolet B (UVB) light up-regulates the expression of matrix metalloproteinase-1 (MMP-1), thus contributing to premature skin aging (photo-aging). Although cyclooxygenase-2 (COX-2) and its product, prostaglandin E2... -
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- Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells
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Kim WK, Sul OJ, Kwak JS, Hur HY, Latour AM, Koller BH, Kwon BS, Jeong CS
- KMID: 1115264
- Exp Mol Med.
- 2010 Dec;42(12):805-810.
- doi: 10.3858/emm.2010.42.12.083
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2... -
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- Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells
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Kwon HY, Kim SJ, Kim CH, Son SW, Kim KS, Lee JH, Do SI, Lee YC
- KMID: 1115269
- Exp Mol Med.
- 2010 Dec;42(12):849-855.
- doi: 10.3858/emm.2010.42.12.088
In this study, we have shown that gene expression of human GD3 synthase (hST8Sia I) is suppressed by triptolide (TPL) in human melanoma SK-MEL-2 cells. To elucidate the mechanism underlying... -
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- Genome-wide linkage analysis for ocular and nasal anthropometric traits in a Mongolian population
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Im SW, Kim HJ, Lee MK, Yi JH, Jargal G, Sung J, Cho SI, Kim JI
- KMID: 1115263
- Exp Mol Med.
- 2010 Dec;42(12):799-804.
- doi: 10.3858/emm.2010.42.12.080
Anthropometric traits for eyes and nose are complex quantitative traits influenced by genetic and environmental factors. To date, there have been few reports on the contribution of genetic influence to... -
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- Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
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Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I
- KMID: 1115265
- Exp Mol Med.
- 2010 Dec;42(12):811-822.
- doi: 10.3858/emm.2010.42.12.084
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases,... -
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- Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
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Jeong HK, Jou I, Joe EH
- KMID: 1115266
- Exp Mol Med.
- 2010 Dec;42(12):823-832.
- doi: 10.3858/emm.2010.42.12.085
It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged... -
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- Novel deletion of the E3A ubiquitin protein ligase gene detected by multiplex ligation-dependent probe amplification in a patient with Angelman syndrome
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Cali F, Ragalmuto , Chiavetta , Calabrese , Fichera M, Vinci M, Ruggeri G, Schinocca , Sturnio M, Romano S, Romano V, Elia M
- KMID: 1115268
- Exp Mol Med.
- 2010 Dec;42(12):842-848.
- doi: 10.3858/emm.2010.42.12.087
Angelman syndrome (AS) is a severe neurobehavioural disorder caused by failure of expression of the maternal copy of the imprinted domain located on 15q11-q13. There are different mechanisms leading to... -
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