- The adaptor protein LAD/TSAd mediates laminin-dependent T cell migration via association with the 67 kDa laminin binding protein
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Park E, Choi Y, Ahn E, Park I, Yun Y
- KMID: 1009394
- Exp Mol Med.
- 2009 Oct;41(10):728-736.
- doi: 10.3858/emm.2009.41.10.079
The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further understand the functions of this protein, we performed yeast two-hybrid screening using TSAd as bait and identified... -
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- Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled
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Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH
- KMID: 1009391
- Exp Mol Med.
- 2009 Oct;41(10):695-706.
- doi: 10.3858/emm.2009.41.10.076
Wnt signaling is known to be important for diverse embryonic and post-natal cellular events and be regulated by the proteins Dishevelled and Axin. Although Dishevelled is activated by Wnt and... -
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- Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
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Wang Z, Jin H, Xu R, Mei Q, Fan D
- KMID: 1009393
- Exp Mol Med.
- 2009 Oct;41(10):717-727.
- doi: 10.3858/emm.2009.41.10.078
Triptolide, a diterpenoid triepoxide from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f., is a potential treatment for autoimmune diseases as well a possible anti-tumor agent. It inhibits proliferation... -
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- alpha-Tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells
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Lim SJ, Choi MK, Kim MJ, Kim JK
- KMID: 1009395
- Exp Mol Med.
- 2009 Oct;41(10):737-745.
- doi: 10.3858/emm.2009.41.10.080
Paclitaxel is one of the chemotheraputic drugs widely used for the treatment of nonsmall cell lung cancer (NSCLC) patients. Here, we tested the ability of alpha-tocopheryl succinate (TOS), another promising... -
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- Comparative study of synonymous codon usage variations between the nucleocapsid and spike genes of coronavirus, and C-type lectin domain genes of human and mouse
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Ahn I, Jeong BJ, Son HS
- KMID: 1009396
- Exp Mol Med.
- 2009 Oct;41(10):746-756.
- doi: 10.3858/emm.2009.41.10.081
Coronaviruses (CoVs) are single-stranded RNA viruses which contain the largest RNA genomes, and severe acute respiratory syndrome coronavirus (SARS-CoV), a newly found group 2 CoV, emerged as infectious disease with... -
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- Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim JH, Um HJ, Park JW, Lee IK, Kwon TK
- KMID: 1009397
- Exp Mol Med.
- 2009 Oct;41(10):757-764.
- doi: 10.3858/emm.2009.41.10.082
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this... -
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- Sequential evolution of IL-17 responses in the early period of allograft rejection
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Min SI, Ha J, Park CG, Won JK, Park YJ, Min SK, Kim SJ
- KMID: 1009392
- Exp Mol Med.
- 2009 Oct;41(10):707-716.
- doi: 10.3858/emm.2009.41.10.077
In addition to CD4+CD25+Foxp3+ regulatory T (T(reg)) cells which protect against autoimmune tissue injury, IL-17-producing CD4+ T (Th17) cells have been recently described and shown to play a crucial role... -
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- Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages
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Shim HK, Kim JY, Kim MJ, Sim HS, Park DW, Sohn JW, Kim MJ
- KMID: 1009390
- Exp Mol Med.
- 2009 Oct;41(10):687-694.
- doi: 10.3858/emm.2009.41.10.075
Legionella bacterium, an intracellular pathogen of mononuclear phagocytes, causes acute fatal pneumonia, especially in patients with impaired cellular immune responses. Until recently, however, the toll-like receptor (TLR) engagement of bacterial... -
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