- Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells
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Seo SR, Seo JT
- KMID: 1088602
- Exp Mol Med.
- 2009 Apr;41(4):269-276.
- doi: 10.3858/emm.2009.41.4.030
Differentiation of neuronal cells has been shown to accelerate stress-induced cell death, but the underlying mechanisms are not completely understood. Here, we find that early and sustained increase in cytosolic... -
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- Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria
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Lee JE, Park H, Ju YS, Kwak M, Kim JI, Oh HY, Seo JS
- KMID: 1088600
- Exp Mol Med.
- 2009 Apr;41(4):253-258.
- doi: 10.3858/emm.2009.41.4.028
It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondrial DNA (mtDNA) copy number and microalbuminuria... -
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- Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury
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Lee MJ, Kwak YK, You KR, Lee BH, Kim DG
- KMID: 1088599
- Exp Mol Med.
- 2009 Apr;41(4):243-252.
- doi: 10.3858/emm.2009.41.4.027
Oxidative stress is critical for causing cardiac injuries during ischemia-reperfusion (IR), yet the molecular mechanism for this remains unclear. In the present study, we observe that hypoxia and reoxygenation, a... -
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- Nickel induces secretion of IFN-gamma by splenic natural killer cells
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Kim JY, Huh K, Lee KY, Yang JM, Kim TJ
- KMID: 1088604
- Exp Mol Med.
- 2009 Apr;41(4):288-295.
- doi: 10.3858/emm.2009.41.4.032
Although nickel hypersensitivity is known as a delayed-type hypersensitivity mediated by nickel-specific T cells, it is greatly influenced by other immune cells. Here we show that splenic natural killer cells... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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- Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts
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Jeong K, Kwon H, Min C, Pak Y
- KMID: 1088597
- Exp Mol Med.
- 2009 Apr;41(4):226-235.
- doi: 10.3858/emm.2009.41.4.025
We investigated the effect of phenylephrine (PE)- and isoproterenol (ISO)-induced cardiac hypertrophy on subcellular localization and expression of caveolin-3 and STAT3 in H9c2 cardiomyoblast cells. Caveolin-3 localization to plasma membrane... -
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- p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases
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El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, Braut-Boucher F
- KMID: 1088596
- Exp Mol Med.
- 2009 Apr;41(4):217-225.
- doi: 10.3858/emm.2009.41.4.058
Phagocytes such as neutrophils play a vital role in host defense against microbial pathogens. The anti-microbial function of neutrophils is based on the production of superoxide anion (O2(.-)), which generates... -
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- Shank 2 expression coincides with neuronal differentiation in the developing retina
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Kim JH, Kim JH, Yang E, Park JH, Yu YS, Kim KW
- KMID: 1088598
- Exp Mol Med.
- 2009 Apr;41(4):236-242.
- doi: 10.3858/emm.2009.41.4.026
The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation... -
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- Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
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Kim SE, Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS
- KMID: 1088603
- Exp Mol Med.
- 2009 Apr;41(4):277-287.
- doi: 10.3858/emm.2009.41.4.031
Matrix metalloproteinase-9 (MMP-9) may play an important role in emphysematous change in chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality and morbidity worldwide. We previously reported... -
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