- Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus
-
Park PG, Lee H
- KMID: 756336
- Exp Mol Med.
- 2008 Jun;40(3):339-344.
- doi: 10.3858/emm.2008.40.3.339
Germ-line mutations in BRCA2 predispose to early-onset cancer. Homozygous mutant mouse, which has Brca2 truncated in exon 11 exhibit paradoxic occurrence of growth retardation and development of thymic lymphomas. However,... -
- CITED
-
- Close
- SHARE
-
- Close
- Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain
-
Kim TH, Huang TQ, Jang JJ, Kim MH, Kim HJ, Lee JS, Pack JK, Seo JS, Park WY
- KMID: 756331
- Exp Mol Med.
- 2008 Jun;40(3):294-303.
- doi: 10.3858/emm.2008.40.3.294
Even though there is no direct evidence to prove the cellular and molecular changes induced by radiofrequency (RF) radiation itself, we cannot completely exclude the possibility of any biological effect... -
- CITED
-
- Close
- SHARE
-
- Close
- A MELAS syndrome family harboring two mutations in mitochondrial genome
-
Choi BO, Hwang JH, Kim J, Cho EM, Cho SY, Hwang SJ, Lee HW, Kim SJ, Chung KW
- KMID: 756338
- Exp Mol Med.
- 2008 Jun;40(3):354-360.
- doi: 10.3858/emm.2008.40.3.354
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous mitochondrial disorder with variable clinical symptoms. Here, from the sequencing of the entire mitochondrial genome, we... -
- CITED
-
- Close
- SHARE
-
- Close
- CD98 activation increases surface expression and clusteringof beta 1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms
-
Kim SM, Hahn JH
- KMID: 756327
- Exp Mol Med.
- 2008 Jun;40(3):261-270.
- doi: 10.3858/emm.2008.40.3.261
CD98, a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein, regulates beta 1 integrin- mediated cell adhesion. However, the molecular mechanisms underlying CD98-mediated activation of beta 1 integrin are presently unclear.... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of sildenafil citrate on interleukin-1beta-induced nitric oxide synthesis and iNOS expression in SW982 cells
-
Kim KO, Park SY, Han CW, Chung HK, Ryu DH, Han JS
- KMID: 756330
- Exp Mol Med.
- 2008 Jun;40(3):286-293.
- doi: 10.3858/emm.2008.40.3.286
The purpose of this study was to identify the effect of sildenafil citrate on IL-1 beta induced nitric oxide (NO) synthesis and iNOS expression in human synovial sarcoma SW982 cells.... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of xanthohumol on melanogenesis in B16 melanoma cells
-
Koo JH, Kim HT, Yoon HY, Kwon KB, Choi IW, Jung SH, Kim HU, Park BH, Park JW
- KMID: 756333
- Exp Mol Med.
- 2008 Jun;40(3):313-319.
- doi: 10.3858/emm.2008.40.3.313
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin... -
- CITED
-
- Close
- SHARE
-
- Close
- Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2
-
Yun HJ, Cho YH, Moon Y, Park YW, Yoon HK, Kim YJ, Cho SH, Lee YI, Kang BS, Kim WJ, Park K, Seo W
- KMID: 756337
- Exp Mol Med.
- 2008 Jun;40(3):345-353.
- doi: 10.3858/emm.2008.40.3.345
For cancer gene therapy, cancer-specific over-expression of a therapeutic gene is required to reduce side effects derived from expression of the gene in normal cells. To develop such an expression... -
- CITED
-
- Close
- SHARE
-
- Close
- Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration
-
Sung HJ, Kim YS, Kang H, Ko J
- KMID: 756335
- Exp Mol Med.
- 2008 Jun;40(3):332-338.
- doi: 10.3858/emm.2008.40.3.332
Chemokines and chemokine receptors play a role in migration of circulating leukocytes to the region of inflammation. Human LZIP is an uncharacterized transcription factor and is known to participate in... -
- CITED
-
- Close
- SHARE
-
- Close
- Predisposition of genetic disease by modestly decreased expression of GCH1 mutant allele
-
Kim YS, Choi YB, Lee JH, Yang SH, Cho JH, Shin CH, Lee SD, Paik MK, Hong KM
- KMID: 756328
- Exp Mol Med.
- 2008 Jun;40(3):271-275.
- doi: 10.3858/emm.2008.40.3.271
Recently it was shown that single nucleotide polymorphisms (SNPs) can explain individual variation because of the small changes of the gene expression level and that the 50% decreased expression of... -
- CITED
-
- Close
- SHARE
-
- Close
- Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury
-
Kim SR, Lee KS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Koh GY, Lee YC
- KMID: 756334
- Exp Mol Med.
- 2008 Jun;40(3):320-331.
- doi: 10.3858/emm.2008.40.3.320
Reactive oxygen species (ROS) play a crucial role in acute lung injury. Tissue inflammation, the increased vascular permeability, and plasma exudation are cardinal features of acute lung injury. Angiopoietin-1 (Ang1)... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells
-
Jung EJ, Kim CW, Kim DR
- KMID: 756329
- Exp Mol Med.
- 2008 Jun;40(3):276-285.
- doi: 10.3858/emm.2008.40.3.276
Tropomyosin-related kinase A (TrkA) plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types. Here we show that TrkA overexpression by the Tet-On... -
- CITED
-
- Close
- SHARE
-
- Close
- Distal hereditary motor neuropathy in Korean patients with a small heat shock protein 27 mutation
-
Chung KW, Kim SB, Cho SY, Hwang SJ, Park SW, Kang SH, Kim J, Yoo JH, Choi BO
- KMID: 756332
- Exp Mol Med.
- 2008 Jun;40(3):304-312.
- doi: 10.3858/emm.2008.40.3.304
Distal hereditary motor neuropathy (dHMN) is a heterogeneous disorder characterized by degeneration of motor nerves in the absence of sensory abnormalities. Recently, mutations in the small heat shock protein 27... -
- CITED
-
- Close
- SHARE
-
- Close
