- Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector
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Kim ES, Kang M, Park HW, Kim MH
- KMID: 1052937
- Exp Mol Med.
- 2008 Apr;40(2):151-160.
- doi: 10.3858/emm.2008.40.2.151
In order to examine whether the Hoxc8 protein can deliver nucleic acid into mammalian cells, we designed several Hoxc8-derived recombinant proteins to be synthesized as glutathione S-transferase (GST) fused forms... -
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- Gene network and canonical pathway analysis in prostate cancer: a microarray study
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Savli H, Szendroi A, Romics I, Nagy B
- KMID: 1052940
- Exp Mol Med.
- 2008 Apr;40(2):176-185.
- doi: 10.3858/emm.2008.40.2.176
The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and... -
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- Secretion of adenylate kinase 1 is required for extracellular ATP synthesis in C2C12 myotubes
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Choo HJ, Kim BW, Kwon OB, Lee CS, Choi JS, Ko YG
- KMID: 1052944
- Exp Mol Med.
- 2008 Apr;40(2):220-228.
- doi: 10.3858/emm.2008.40.2.220
Extracellular ATP (exATP) has been known to be a critical ligand regulating skeletal muscle differentiation and contractibility. ExATP synthesis was greatly increased with the high level of adenylate kinase 1... -
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- Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis
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Shin SH, Kim HS, Jung SH, Xu HD, Jeong YB, Chung YJ
- KMID: 1052945
- Exp Mol Med.
- 2008 Apr;40(2):229-236.
- doi: 10.3858/emm.2008.40.2.229
Molecular mechanism of lung carcinogenesis and its aggressive nature is still largely elusive. To uncover the biomarkers related with tumorigenesis and behavior of lung cancer, we screened novel differentially expressed... -
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- Transient downregulation of protein O-N-acetylglucosaminylation by treatment of high-dose nicotinamide in human cells
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Lee HI, Cho HJ, Han JA, Jang SY, Wang KM, Kang HT, Hwang ES
- KMID: 1052947
- Exp Mol Med.
- 2008 Apr;40(2):246-253.
- doi: 10.3858/emm.2008.40.2.246
Nicotinamide at millimolar concentrations affects cell survival in various conditions, and is being utilized therapeutically in many human diseases. However, the effect of an acute treatment of nicotinamide at such... -
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- Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
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Byun HS, Won M, Park KA, Kim YR, Choi BL, Lee H, Hong JH, Piao L, Park J, Kim JM, Kweon GR, Kang SH, Han J, Hur GM
- KMID: 1052941
- Exp Mol Med.
- 2008 Apr;40(2):186-195.
- doi: 10.3858/emm.2008.40.2.186
Previous studies have demonstrated that rottlerin, a specific PKCdelta inhibitor, potentiates death receptor- mediated apoptosis through a cytochrome c-dependent or -independent pathway. However, its ability to regulate necrotic cell death,... -
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- T-CAM, a fastatin-FIII 9-10 fusion protein, potently enhances anti-angiogenic and anti-tumor activity via alphavbeta3 and alpha5beta1 integrins
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Nam JO, Jung MY, Thapa N, Lee BH, Park RW, Kim IS
- KMID: 1052942
- Exp Mol Med.
- 2008 Apr;40(2):196-207.
- doi: 10.3858/emm.2008.40.2.196
We made fusion protein of fastatin and FIII 9-10, termed tetra-cell adhesion molecule (T-CAM) that can interact simultaneously with alphavbeta3 and alpha5beta1 integrins, both playing important roles in tumor angiogenesis.... -
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- Polymorphisms in two genes, IL-1B and ACE, are associated with erythropoietin resistance in Korean patients on maintenance hemodialysis
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Jeong KH, Lee TW, Ihm CG, Lee SH, Moon JY
- KMID: 1052938
- Exp Mol Med.
- 2008 Apr;40(2):161-166.
- doi: 10.3858/emm.2008.40.2.161
Genetic polymorphisms may be linked to inter-individual differences in erythropoietin (EPO) resistance. We investigated the -511C/T polymorphism of the IL-1B gene and the I/D polymorphism of the ACE gene for... -
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- An NH(2)-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells
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Jeon S, Kim KH, Yun CH, Hong BW, Chang YS, Han HS, Yoon YS, Choi WB, Kim S, Lee AY
- KMID: 1052948
- Exp Mol Med.
- 2008 Apr;40(2):254-260.
- doi: 10.3858/emm.2008.40.2.254
Cytochrome P450 3A4 (CYP3A4), is the dominant human liver hemoprotein enzyme localized in the endoplasmic reticulum (ER), and is responsible for the metabolism of more than 50% of clinically relevant... -
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- TNF-alpha-induced up-regulation of intercellular adhesion molecule-1 is regulated by a Rac-ROS-dependent cascade in human airway epithelial cells
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Kim H, Hwang JS, Woo CH, Kim EY, Kim TH, Cho KJ, Kim JH, Seo JM, Lee SS
- KMID: 1052939
- Exp Mol Med.
- 2008 Apr;40(2):167-175.
- doi: 10.3858/emm.2008.40.2.167
Up-regulation of intercellular adhesion molecule-1 (ICAM-1) in the lung airway epithelium is associated with the epithelium-leukocyte interaction, critical for the pathogenesis of various lung airway inflammatory diseases such as asthma.... -
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- IL-17 induces the production of IL-16 in rheumatoid arthritis
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Cho ML, Jung YO, Kim KW, Park MK, Oh HJ, Ju JH, Cho YG, Min JK, Kim SI, Park SH, Kim HY
- KMID: 1052946
- Exp Mol Med.
- 2008 Apr;40(2):237-245.
- doi: 10.3858/emm.2008.40.2.237
The purpose of this study was to investigate the expression of IL-16 in the rheumatoid synovium and the role of inflammatory cytokines and Toll-like receptor (TLR) ligands in IL-16 production... -
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- Transcriptional profiling in human HaCaT keratinocytes in response to kaempferol and identification of potential transcription factors for regulating differential gene expression
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Kang BY, Kim S, Lee KH, Lee YS, Hong I, Lee MO, Min D, Chang I, Hwang JS, Park JS, Kim DH, Kim BG
- KMID: 1052943
- Exp Mol Med.
- 2008 Apr;40(2):208-219.
- doi: 10.3858/emm.2008.40.2.208
Kaempferol is the major flavonol in green tea and exhibits many biomedically useful properties such as antioxidative, cytoprotective and anti-apoptotic activities. To elucidate its effects on the skin, we investigated... -
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