- WNKs: protein kinases with a unique kinase domain
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Huang CL, Cha SK, Wang HR, Xie J, Cobb MH
- KMID: 1090959
- Exp Mol Med.
- 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in... -
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- Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix
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Lee EH, Allen PD
- KMID: 1090962
- Exp Mol Med.
- 2007 Oct;39(5):594-602.
To investigate the mechanism by which the C-terminus (4,938-5,037) of the ryanodine receptor 1 (RyR1) homo-tetramerizes, forming a functional Ca2+ -release channel, the structural requirements for the tetramerization were studied... -
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- Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma
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Yu GR, Kim SH, Park SH, Cui XD, Xu DY, Yu HC, Cho BH, Yeom YI, Kim SS, Kim SB, Chu IS, Kim DG
- KMID: 1090967
- Exp Mol Med.
- 2007 Oct;39(5):641-652.
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene... -
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- Recombinant tetra-cell adhesion motifs supports adhesion, migration and proliferation of keratinocytes/fibroblasts, and promotes wound healing
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Jung MY, Thapa N, Kim JE, Yang JD, Cho BC, Kim IS
- KMID: 1090969
- Exp Mol Med.
- 2007 Oct;39(5):663-672.
An extracellular matrix protein plays an important role in skin wound healing. In the present study, we engineered a recombinant protein encompassing the 9th and 10th type III domains of... -
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- Immunocytochemical detection of HPV16 E7 in cervical smear
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Jeon JH, Shin DM, Cho SY, Song KY, Park NH, Kang HS, Kim YD, Kim IG
- KMID: 1090965
- Exp Mol Med.
- 2007 Oct;39(5):621-628.
Cervical cancer is characterized by a long period of preclinical dysplasia or carcinoma in situ progressing into invasive cancer. Although Papanicolaou (Pap) smear test has contributed significantly to the early... -
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- Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells
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Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS
- KMID: 1090961
- Exp Mol Med.
- 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as... -
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- Cardiac side population cells exhibit endothelial differentiation potential
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Yoon J, Choi SC, Park CY, Shim WJ, Lim DS
- KMID: 1090968
- Exp Mol Med.
- 2007 Oct;39(5):653-662.
Recent studies have shown that side population (SP) cells, isolated from adult myocardium, represent a distinct cardiac progenitor cell population that exhibits functional cardiomyogenic differentiation. However, information on the intrinsic... -
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- Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons
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Kim HJ, Im W, Kim S, Kim SH, Sung JJ, Kim M, Lee KW
- KMID: 1090960
- Exp Mol Med.
- 2007 Oct;39(5):574-582.
Familial amyotrophic lateral sclerosis (fALS) is caused by mutations in Cu/Zn-superoxide dismutase (SOD1), and SOD1 aggregation and calcium toxicity are involved in neuronal death. However, the effect of altered calcium... -
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- Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration
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Jeon S, Kim NH, Koo BS, Lee HJ, Lee AY
- KMID: 1090963
- Exp Mol Med.
- 2007 Oct;39(5):603-613.
Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A2(sPLA2) known as a component of bee venom (BV), stimulates... -
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- Change of connexin 37 in allergen-induced airway inflammation
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Park SJ, Lee KS, Kim SR, Min KH, Lee KY, Choe YH, Park SY, Hong SH, Lee YC
- KMID: 1090966
- Exp Mol Med.
- 2007 Oct;39(5):629-640.
Gap junction channels formed with connexins directly link to the cytoplasm of adjacent cells and have been implicated in intercellular signaling. Connexin 37 (Cx37) is expressed in the gas-exchange region... -
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- Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action
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Park KH, Kim JS, Lee YR, Moon YJ, Hur H, Choi YH, Kim CH, Kim UH, Song EK, Yoo WH, Lee CS, Kim BS, Lee SH, Ryu PY, Han MK
- KMID: 1090970
- Exp Mol Med.
- 2007 Oct;39(5):673-678.
Lipoprotein plays a role in the host defense against bacterial infection, and its serum level has been demonstrated to be an important prognosis factor of survival. We have previously demonstrated... -
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- Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema
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Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I
- KMID: 1090964
- Exp Mol Med.
- 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to... -
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