- Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells
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Park HY, Jeon YK, Shin HJ, Kim IJ, Kang HC, Jeong SJ, Chung DH, Lee CW
- KMID: 1094660
- Exp Mol Med.
- 2007 Apr;39(2):195-204.
The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation of chromosome-spindle attachment to mitotic-checkpoint signaling. Thus, disruption of BubR1 activity results in a loss of... -
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- Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif
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Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J
- KMID: 1094661
- Exp Mol Med.
- 2007 Apr;39(2):205-212.
Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate... -
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- Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins
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Kim MK, Park KS, Lee H, Kim YD, Yun J, Bae YS
- KMID: 1094659
- Exp Mol Med.
- 2007 Apr;39(2):185-194.
Phytosphingosine-1-phosphate (PhS1P) was found to stimulate an intracellular calcium increase via phospholipase C but not pertussis toxin (PTX)- sensitive G-proteins in L2071 mouse fibroblasts. PhS1P also activated ERK and p38... -
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- Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo
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Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S
- KMID: 1094657
- Exp Mol Med.
- 2007 Apr;39(2):170-175.
The aims of this study were to evaluate the expression of enhanced green fluorescent protein (EGFP) driven by 6 different promoters, including cytomegalovirus IE enhancer and chicken beta-actin promoter (CAG),... -
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- Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression
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Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C
- KMID: 1094665
- Exp Mol Med.
- 2007 Apr;39(2):239-245.
Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated... -
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- Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
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Park CE, Kim MJ, Lee JH, Min BI, Bae H, Choe W, Kim SS, Ha J
- KMID: 1094663
- Exp Mol Med.
- 2007 Apr;39(2):222-229.
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive properties. However antidiabetic effect of... -
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- A point mutant of apolipoprotein A-I, V156K, exhibited potent anti-oxidant and anti-atherosclerotic activity in hypercholesterolemic C57BL/6 mice
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Cho KH, Park SH, Han JM, Kim HC, Chung YJ, Choi I, Kim JR
- KMID: 1094656
- Exp Mol Med.
- 2007 Apr;39(2):160-169.
In our previous study, two point mutants of apolipoprotein A-I, designated V156K and A158E, revealed peculiar characteristics in their lipid-free and lipid-bound states. In order to determine the putative therapeutic... -
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- CD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR zeta
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Oh KI, Kim BK, Ban YL, Choi EY, Jung KC, Lee IS, Park SH
- KMID: 1094658
- Exp Mol Med.
- 2007 Apr;39(2):176-184.
We investigated the co-stimulatory role of a cell-surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or... -
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- Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production
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Lee SJ, Namkoong S, Ha KS, Nam WD, Kwon YG, Lee H, Yoon EY, Chang DJ, Kim SO, Kim YM
- KMID: 1094664
- Exp Mol Med.
- 2007 Apr;39(2):230-238.
Colchicine has been shown to regulate the expression of inflammatory gene, but this compound possesses much weaker anti-inflammatory activity. In this study, we synthesized a new colchicine derivative CT20126 and... -
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- Curcumin reduces cold storage-induced damage in human cardiac myoblasts
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Abuarqoub , Green CJ, Foresti R, Motterlini R
- KMID: 1094654
- Exp Mol Med.
- 2007 Apr;39(2):139-148.
Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). The objective of this study was to... -
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- Trichostatin A-mediated upregulation of p21
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Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM
- KMID: 1094662
- Exp Mol Med.
- 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about... -
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- Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation
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Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH
- KMID: 1094655
- Exp Mol Med.
- 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma... -
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- p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
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Ko J, Yun CY, Lee JS, Kim JH, Kim IS
- KMID: 1094653
- Exp Mol Med.
- 2007 Apr;39(2):129-138.
9-cis-retinoic acid (9CRA) plays an important role in the immune response; this includes cytokine production and cell migration. We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1... -
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