- Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells
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Kim BW, Son H
- KMID: 1115952
- Exp Mol Med.
- 2006 Dec;38(6):732-738.
It has been shown that neural cell adhesion molecule (NCAM)-induced neuronal differentiation is extracellular signal-regulated kinase (ERK)-dependent. However, an involvement of the mitogen activated protein kinase (MAPK) kinase (MEK), an... -
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- Efficient amplification of melanoma-specific CD8+ T cells using artificial antigen presenting complex
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Chang J
- KMID: 1115936
- Exp Mol Med.
- 2006 Dec;38(6):591-598.
In vitro large amplification of tumor-specific cytotoxic T lymphocytes (CTLs) and adoptive transfer of these cells is one of the most promising approaches to treat malignant diseases in which an... -
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- Heterozygosities of 735 microsatellite markers and background linkage disequilibrium in the Korean population
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Lee KA, Kim JW
- KMID: 1115944
- Exp Mol Med.
- 2006 Dec;38(6):662-667.
Suitability of a specific population for linkage disequilibrium mapping studies of complex traits may be assessed by investigating the background linkage disequilibrium (BLD). We are unaware of studies for quantifying... -
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- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
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Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
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- The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways
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Shin SY, Lee JH, Min B, Lee YH
- KMID: 1115946
- Exp Mol Med.
- 2006 Dec;38(6):677-685.
The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated... -
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- No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population
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Ahn K, Kim E, Kwon YA, Kim DK, Lee JE, Jo SA
- KMID: 1115951
- Exp Mol Med.
- 2006 Dec;38(6):727-731.
The polymorphism at codon 129 (M129V) of the human prion protein gene (PRNP) is a known risk factor for Creutzfeldt-Jakob disease (CJD) in Caucasians. There are few reports of this... -
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- Epidemiological comparisons of codon usage patterns among HIV-1 isolates from Asia, Europe, Africa and the Americas
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Ahn I, Son HS
- KMID: 1115942
- Exp Mol Med.
- 2006 Dec;38(6):643-651.
To investigate the genomic properties of HIV-1, we collected 3,081 sequences from the HIV Sequence Database. The sequences were categorized according to sampling region, country, year, subtype, gene name, and... -
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- Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte
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Choi BH, Ahn IS, Kim YH, Park JW, Lee SY, Hyun CK, Do MS
- KMID: 1115937
- Exp Mol Med.
- 2006 Dec;38(6):599-605.
Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the... -
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- Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence
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Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH
- KMID: 1115947
- Exp Mol Med.
- 2006 Dec;38(6):686-693.
The gradual loss of telomeric DNA can contribute to replicative senescence and thus, having longer telomeric DNA is generally considered to provide a longer lifespan. Maintenance and stabilization of telomeric... -
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- Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells
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Kwak DH, Yu K, Kim SM, Lee DH, Kim SM, Jung JU, Seo JW, Kim N, Lee SK, Jung KY, You H, Kim HA, Choo YK
- KMID: 1115945
- Exp Mol Med.
- 2006 Dec;38(6):668-676.
Stem cells are used for the investigation of developmental processes at both cellular and organism levels and offer tremendous potentials for clinical applications as an unlimited source for transplantation. Gangliosides,... -
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- Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance
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Park BL, Kim YJ, Cheong HS, Kim LH, Choi YH, Lee HS, Shin HD
- KMID: 1115948
- Exp Mol Med.
- 2006 Dec;38(6):694-702.
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the... -
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- Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts
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Lee KM
- KMID: 1115949
- Exp Mol Med.
- 2006 Dec;38(6):703-717.
Diverse signaling pathways have been proposed to regulate store-operated calcium entry (SOCE) in a wide variety of cell types. However, it still needs to be determined if all of these... -
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- 4-1BB (CD137) signals depend upon CD28 signals in alloimmune responses
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Lee EA, Kim JE, Seo JH, Kwon BS, Nam SH, Kwon B, Cho HR
- KMID: 1115938
- Exp Mol Med.
- 2006 Dec;38(6):606-615.
Our previous study has demonstrated that there is a significant delay of Balb/c cardiac allograft rejection in the C57BL/6 4-1BB-deficient knockout recipient. In this study, we examined the effect of... -
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- Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
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Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, Lee JH, Youn MJ, So HS, Park R
- KMID: 1115939
- Exp Mol Med.
- 2006 Dec;38(6):616-624.
Trichostatin A (TSA), originally developed as an antifungal agent, is one of potent histone deacetylase (HDAC) inhibitors, which are known to cause growth arrest and apoptosis induction of transformed cells,... -
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- Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria
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Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS
- KMID: 1115943
- Exp Mol Med.
- 2006 Dec;38(6):652-661.
Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine b-synthase (CBS). The major clinical symptoms of this disease are mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms,... -
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- Discovery of a small-molecule inhibitor for kidney ADP-ribosyl cyclase: Implication for intracellular calcium signal mediated by cyclic ADP-ribose
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Nam TS, Choi SH, Rah SY, Kim SY, Jang W, Im MJ, Kwon HJ, Kim UH
- KMID: 1115950
- Exp Mol Med.
- 2006 Dec;38(6):718-726.
ADP-ribosyl cyclase (ADPR-cyclase) produces a Ca2+-mobilizing second messenger, cyclic ADP- ribose (cADPR), from beta-NAD+. A prototype of mammalian ADPR-cyclases is a lymphocyte antigen CD38. Accumulating evidence indicates that ADPR-cyclases other... -
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- zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells
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Yee SB, Baek SJ, Park HT, Jeong SH, Jeong JH, Kim TH, Kim JM, Jeong BK, Park BS, Kwon TK, Yoon I, Yoo YH
- KMID: 1115941
- Exp Mol Med.
- 2006 Dec;38(6):634-642.
In a preliminary study, we found that benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD- fmk), unlike Boc-aspartyl(OMe)-fluoromethylketone (BocD-fmk), at usual dosage could not prevent genistein-induced apoptosis of p815 mastocytoma cells. This study was undertaken to... -
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