- Retraction: Shear stress stimulates phosphorylation of protein kinase A substrate proteins including endothelial nitric oxide synthase in endothelial cells
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Boo YC
- KMID: 1110130
- Exp Mol Med.
- 2006 Aug;38(4):453-453.
This article is retracted by the request of the corresponding author. The corresponding author is deeply sorry for any inconvenience this may have caused to the Experimental and Molecular Medicine... -
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- SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury
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Lee KH, Kim SE, Lee YS
- KMID: 1110125
- Exp Mol Med.
- 2006 Aug;38(4):408-416.
c-Jun N-terminal kinase (JNK) is activated during hepatic reperfusion, and JNK inhibitors are known to protect other major organs from ischemia-reperfusion (I/R) injury. We attempted to determine the effect of... -
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- Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2
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Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH
- KMID: 1110121
- Exp Mol Med.
- 2006 Aug;38(4):375-384.
Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydrolysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2 (PLD2) activity in rat pheochromocytoma PC12... -
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- Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus
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Kim JM, Kim SJ, Lee HC, Kim KS
- KMID: 1110122
- Exp Mol Med.
- 2006 Aug;38(4):385-392.
To develop an inducible expression system, the enhanced artificial nuclear receptors and target reporters were constructed. Artificial nuclear receptors were generated by fusing three domains, consisting of DNA-binding domain (DBD)... -
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- Metabolic loading of guanosine induces chondrocyte apoptosis via the Fas pathway
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Kim DJ, Chung JH, Ryu EK, Rhim JH, Ryu YS, Park SH, Kim KT, Kang HS, Chung HK, Park SC
- KMID: 1110124
- Exp Mol Med.
- 2006 Aug;38(4):401-407.
Although the apoptosis of chondrocytes plays an important role in endochondral ossification, its mechanism has not been elucidated. In this study, we show that guanosine induces chondrocyte apoptosis based on... -
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- Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
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Kim YS, Joh TH
- KMID: 1110117
- Exp Mol Med.
- 2006 Aug;38(4):333-347.
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's... -
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- CD43 cross-linking increases the Fas-induced apoptosis through induction of Fas aggregation in Jurkat T-cells
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Kim HJ, Park HJ, Park WS, Bae Y
- KMID: 1110119
- Exp Mol Med.
- 2006 Aug;38(4):357-363.
CD43 (sialophorin, leukosialin) is a heavily sialylated surface protein expressed on most leukocytes and platelets including T cells. Although CD43 antigen is known to have multiple and complex structure, exact... -
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- Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease: implications for neuronal loss in Gaucher disease
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Kim EY, Hong YB, Go SH, Lee B, Jung SC
- KMID: 1110118
- Exp Mol Med.
- 2006 Aug;38(4):348-356.
Gaucher disease is a glycosphingolipid storage disease caused by deficiency of glucocerebrosidase, resulting in the accumulation of glucosylceramide in lysosomes. The neuronopathic forms of this disease are associated with neuronal... -
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- Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death
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Gong X, Wang M, Tashiro SI, Onodera S, Ikejima T
- KMID: 1110127
- Exp Mol Med.
- 2006 Aug;38(4):428-434.
A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor... -
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- Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice
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Nam KH, Choi JH, Seo YJ, Lee YM, Won YS, Lee MR, Lee MN, Park JG, Kim YM, Kim HC, Lee CH, Lee HK, Oh SR, Oh GT
- KMID: 1110129
- Exp Mol Med.
- 2006 Aug;38(4):445-452.
We investigated the effect of tilianin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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- Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protection
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Jeong GS, Oh GS, Pae HO, Jeong SO, Kim YC, Shin MK, Seo BY, Han SY, Lee HS, Jeong JG, Koh JS, Chung HT
- KMID: 1110123
- Exp Mol Med.
- 2006 Aug;38(4):393-400.
Recently, it has been reported that curcumin, which is known as a potent antioxidant, acts as a non-stressful and non-cytotoxic inducer of the cytoprotective heme oxygenase (HO)-1. In this study,... -
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- Release of heat shock protein 70 (Hsp70) and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells
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Lee KJ, Kim YM, Kim DY, Jeoung D, Han K, Lee ST, Lee YS, Park KH, Park JH, Kim DJ, Hahn JH
- KMID: 1110120
- Exp Mol Med.
- 2006 Aug;38(4):364-374.
Heat shock protein 70 (Hsp70) release and its effects on pro-inflammatory cytokine production have been controversial. In this study, we investigated whether Hsp70 could be released from monocytes and activates... -
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- Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression
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Kim DH, Cho IH, Kim HS, Jung JE, Kim JE, Lee KH, Park T, Yang YM, Seong SY, Ye SK, Chung MH
- KMID: 1110126
- Exp Mol Med.
- 2006 Aug;38(4):417-427.
To elucidate the roles of 8-hydroxydeoxyguanosine (oh8dG), the nucleoside of 8-hydroxyguanine (oh8Gua), we examined the effects of oh8dG upon LPS-induced intercellular adhesion molecule-1 (ICAM-1) expression and the underlying mechanisms in... -
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