- Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing
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Kang MJ, Chung YH, Hwang CI, Murata M, Fujimoto T, Mook-Jung , Cha CI, Park WY
- KMID: 1111405
- Exp Mol Med.
- 2006 Apr;38(2):126-133.
Lipid rafts provide a platform for regulating cellular functions and participate in the pathogenesis of several diseases. However, the role of caveolin-1 in this process has not been elucidated definitely... -
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- Diagnostic mutational analysis of MECP2 in Korean patients with Rett syndrome
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Kim IJ, Kim YJ, Son BH, Nam SO, Kang HC, Kim HD, Yoo MA, Choi OH, Kim CM
- KMID: 1111404
- Exp Mol Med.
- 2006 Apr;38(2):119-125.
Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder affecting 1 per 10,000- 15,000 female births worldwide. The disease-causing gene has been identified as MECP2 (methyl- CpG-binding protein 2). In... -
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- Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts
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Jang IS, Rhim JH, Park SC, Yeo EJ
- KMID: 1111406
- Exp Mol Med.
- 2006 Apr;38(2):134-143.
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid... -
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- Protein kinase A-dependent phosphorylation of B/K protein
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Chin H, Choi SH, Jang YS, Cho SM, Kim HS, Lee JH, Jeong SW, Kim IK, Kim GJ, Kwon OJ
- KMID: 1111407
- Exp Mol Med.
- 2006 Apr;38(2):144-152.
We have previously isolated a novel protein "B/K" that contains two C2-like domains. Here, we report the isolatioin and mRNA distribution of a human B/K isoform, and protein kinase A... -
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- betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin
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Lee BH, Bae JS, Park RW, Kim JE, Park JY, Kim IS
- KMID: 1111408
- Exp Mol Med.
- 2006 Apr;38(2):153-161.
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes involve the interaction of VSMCs with extracellular matrix proteins. Here,... -
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- Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation
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Kim JR, Ryu HH, Chung HJ, Lee JH, Kim SW, Kwun WH, Baek SH, Kim JH
- KMID: 1111409
- Exp Mol Med.
- 2006 Apr;38(2):162-172.
People with upper body or visceral obesity have a much higher risk of morbidity and mortality from obesity-related metabolic disorders than those with lower body obesity. In an attempt to... -
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- Inhibition of corneal neovascularization by rapamycin
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Kwon YS, Kim JC
- KMID: 1111410
- Exp Mol Med.
- 2006 Apr;38(2):173-179.
The purpose of this study was to determine whether rapamycin could inhibit corneal angiogenesis induced by basic fibroblast growth factor (bFGF). Using human dermal microvascular endothelial cells (HDMECs), we examined... -
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- Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes
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Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ
- KMID: 1111411
- Exp Mol Med.
- 2006 Apr;38(2):180-189.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 translocation have been demonstrated; however, the... -
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- The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model
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Muz MH, Deveci F, Bulut Y, Ilhan N, Yekeler H, Turgut T
- KMID: 1111403
- Exp Mol Med.
- 2006 Apr;38(2):109-118.
Airway structural changes that occur in patients with asthma in response to persistent inflammation are termed airway remodeling. The cysteinyl leukotrienes (LTC4, D4 and E4) are known to play important... -
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