- A model for the reaction mechanism of the transglutaminase 3 enzyme
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Ahvazi B, Steinert P
- KMID: 1109310
- Exp Mol Med.
- 2003 Aug;35(4):228-242.
Transglutaminase enzymes (TGases) catalyze the calcium dependent formation of an isopeptide bond between protein-bound glutamine and lysine substrates. Previously we have shown that activated TGase 3 acquires two additional calcium... -
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- Study of the difference of high and low metastasis cell line's gene expression map and metastasis-related genes of adenoid cystic carcinoma
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Zhu N, Yang J, Wang Y, Guan X
- KMID: 1109311
- Exp Mol Med.
- 2003 Aug;35(4):243-248.
We searched for metastasis-related genes in adenoid cystic carcinoma by suppression subtractive hybridization analysis of high and low metastasis cell lines. Twelve genes (ten previously identified and two novel sequences)... -
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- A decrease in the expression of CD63 tetraspanin protein elevates invasive potential of human melanoma cells
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Jang HI, Lee H
- KMID: 1109322
- Exp Mol Med.
- 2003 Aug;35(4):317-323.
CD63, which belongs to the tetraspanin membrane proteins, has been proposed to play an important role in inhibiting melanoma metastasis. To determine whether reduction of CD63 expression, which frequently occurs... -
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- Molecular identification of Ca(2+)channels in human sperm
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Park JY, Ahn HJ, Gu JG, Lee KH, Kim JS, Kang HW, Lee JH
- KMID: 1109318
- Exp Mol Med.
- 2003 Aug;35(4):285-292.
The acrosome reaction is a Ca(2+)-dependent exocytotic process that is a prerequisite step for fertilization. External calcium entry through voltage-activated Ca(2+)channels is known to be essential in inducing the acrosome... -
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- Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling
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Sung YK, Hwang SY, Farooq M, Kim JC, Kim MK
- KMID: 1109313
- Exp Mol Med.
- 2003 Aug;35(4):257-262.
Glypican-3 (GPC3) encodes a cell-surface heparan-sulfate proteoglycan and its expression is frequently silenced in ovarian cancer, mesotheliomas, and breast cancer cell lines and ectopic expression of GPC3 inhibited the growth... -
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- Detection of antibodies against glucose 6-phosphate isomerase in synovial fluid of rheumatoid arthritis using surface plasmon resonance (BIAcore)
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Kim JY, Lee MH, Jung KI, Na HY, Cha HS, Ko EM, Kim TJ
- KMID: 1109321
- Exp Mol Med.
- 2003 Aug;35(4):310-316.
We have used a surface plasmon resonance biosensor (SPR, BIACORE 2000) to detect antibodies against glucose 6-phosphate isomerase (GPI) in synovial fluids of rheumatoid arthritis (RA) and osteoarthritis (OA). Recombinant... -
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- N-Acetyl-beta-D-glucosaminidase in acute myocardial infarction
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Iqbal MP, Kazmi KA, Jafri HR, Mehboobali N
- KMID: 1109316
- Exp Mol Med.
- 2003 Aug;35(4):275-278.
The objective of the study was to investigate whether the lysosomal enzyme, N-Acetyl-beta-D-glucosaminidase (NAG) activity is increased in plasma of patients with acute myocardial infarction (AMI) and to determine if... -
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- Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2
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Kim BE, Roh SR, Kim JW, Jeong SW, Kim IK
- KMID: 1109319
- Exp Mol Med.
- 2003 Aug;35(4):293-300.
Cyclopentenone prostaglandins (PGs) have antiproliferative activity on various tumor cell growth in vitro. Particularly, 9-deoxy-(9,12)-13,14-dihydro PGD2( delta12-PGJ2) was reported for its antineoplastic and apoptotic effects on various cancer cells, but... -
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- Human glutamate dehydrogenase is immunologically distinct from other mammalian orthologues
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Jang SH, Kim AY, Bahn JH, Eum WS, Kim DW, Park J, Lee KS, Kang TC, Won MH, Kang JH, Kwon OS, Yoon HY, Lee EY, Cho SW, Choi SY
- KMID: 1109312
- Exp Mol Med.
- 2003 Aug;35(4):249-256.
Five monoclonal antibodies (mAbs) that recognize human glutamate dehydrogenase (GDH) have been selected and designated as monoclonal antibodies hGDH60-6, hGDH60-8, hGDH63-10, hGDH63-11, and hGDH91-14. A total of five mAbs recognizing... -
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- Melatonin reduces ultraviolet-B induced cell damages and polyamine levels in human skin fibroblasts in culture
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Lee KS, Lee WS, Suh SI, Kim SP, Lee SR, Ryoo YW, Kim BC
- KMID: 1109314
- Exp Mol Med.
- 2003 Aug;35(4):263-268.
UV radiation is known to cause photoaging of the skin and is considered one of the leading cause of developing skin carcinogenesis. Melatonin which has a highly lipophilic molecular structure... -
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- Lipid rafts are important for the association of RANK and TRAF6
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Ha H, Kwak HB, Le SW, Kim HH, Lee ZH
- KMID: 1109317
- Exp Mol Med.
- 2003 Aug;35(4):279-284.
Rafts, cholesterol- and sphingolipid-rich membrane microdomains, have been shown to play an important role in immune cell activation. More recently rafts were implicated in the signal transduction by members of... -
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- Activation of calcium signaling by hepatitis B virus-X protein in liver cells
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Oh JC, Jeong DL, Kim IK, Oh SH
- KMID: 1109320
- Exp Mol Med.
- 2003 Aug;35(4):301-309.
Hepatitis B virus x gene product (HBx) is known to be a transactivator of transcriptional elements that regulate the expression of a variety of genes associated with the growth, differentiation,... -
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- Development of an efficient endothelial cell specific vector using promoter and 5' untranslated sequences from the human preproendothelin-1 gene
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Cho JY, Lim WC, Jang S, Lee YJ
- KMID: 1109315
- Exp Mol Med.
- 2003 Aug;35(4):269-274.
We report here, that a vector constructed based on ppET-1 gene promoter and 5' untranslated region induced a high level of gene expression in endothelial cells and the specificity is... -
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