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Heterogeneous HBV mutants coexist in Korean hepatitis B patients

Keum WK, Kim JY, Kim JY, Chi SG, Hong JW, Kim SS, Ha JH, Kang IS

  • KMID: 754997
  • Exp Mol Med.
  • 1998 Jun;30(2):115-122.
Although many hepatitis B virus (HBV) mutants have been found in all open reading frames since the precore defective mutant was initially reported, systematic investigations of diverse HBV mutant populations in hepatitis...
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Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers

Kim JR, Kim SY, Kim MJ, Kim JH

  • KMID: 754996
  • Exp Mol Med.
  • 1998 Jun;30(2):109-114.
The CDKN2 (MTS1/p16INK4A) gene, encoding cyclin dependent kinase inhibitor, was found to be homozygously deleted at a high frequency in cell lines from many different types of cancer and some primary cancers....
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Molecular biological characterization of enterovirus variant isolated from patients with aseptic meningitis

Jung YT, Kim GR, Paik SY

  • KMID: 754995
  • Exp Mol Med.
  • 1998 Jun;30(2):101-107.
In Korea, there was a big outbreak of aseptic meningitis in 1993. Six clinical isolates of enterovirus were obtained from patients with aseptic meningitis and were identified as echovirus type 9 by...
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Partial purification and characterization of a novel murine factor that augments the expression of class I MHC antigens on tumor cells

Puri N, Saxena RK

  • KMID: 754994
  • Exp Mol Med.
  • 1998 Jun;30(2):93-99.
A soluble factor which augments the expression of major histocompatibility complex class I (MHC I) antigens on a number of murine tumor cell lines, has been isolated from the culture supernatants of...
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Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells

Kim SH, Yeo GS, Lim YS, Kang CD, Kim CM, Chung BS

  • KMID: 754993
  • Exp Mol Med.
  • 1998 Jun;30(2):87-92.
MDR1 promoter has been shown to contain heat shock elements (HSE), and it has been reported that FM3A/M and P388/M MDR cells show a constitutively activated heat shock factor (HSF), suggesting that...
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A new member of alpha 1-adrenoceptor-coupled G alpha h (transglutaminase II) family in pig heart: purification and characterization

Yoo SM, Jeong HS, Han KJ, Cho SH, Lee HS, Yun HY, Kwon NS, Baek KJ

  • KMID: 754992
  • Exp Mol Med.
  • 1998 Jun;30(2):81-86.
We previously reported an identification of a 77-kDa GTP-binding protein that co-purified with the alpha 1-adrenoceptor following ternary complex formation. In the present paper, we report on the purification and characterization of...
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Rapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid

Park CE, Ko SM, Kim JM, Yoon MY, Kim JY, Kang IS, Kim SS, Ha JH

  • KMID: 754991
  • Exp Mol Med.
  • 1998 Jun;30(2):73-79.
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, alpha and beta, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-alpha is highly expressed in lipogenic tissues whereas...
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Expression of a recombinant branched chain alpha-oxo acid dehydrogenase complex E2 (BCOADC-E2) in insect cells and its immunoreactivity to autoimmune sera

Lee SM, Ko SH, Park JE, Cha SH

  • KMID: 754990
  • Exp Mol Med.
  • 1998 Jun;30(2):65-71.
Preparation of a pure autoantigen by way of recombinant DNA technology has an important value in an accurate diagnosis or prognosis of an autoimmune disease. BCOADC-E2 subunit, a mitochondrial protein, has been...
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Interferon-gamma upregulates the stromelysin-1 gene expression by human skin fibroblasts in culture

Lee KS, Ryoo YW, Song JY

  • KMID: 754989
  • Exp Mol Med.
  • 1998 Jun;30(2):59-64.
The equilibrium between deposition and degradation of extracellular matrix(ECM) is essential to normal tissue development and repair of wound or inflammatory responses. It has recently become apparent that several cytokines and growth factors...
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