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[Na+]i, [K+]i and [Cl-]i regulation of exocytosis in guinea-pig antral mucous cells

Nakahari T, Fujiwara S, Shimamoto

Effects of intracellular Na+, K+ and Cl- on Ca(2+)-regulated exocytosis activated by 10 microM acetylcholine (ACh) were studied in guinea-pig antral mucous cells which are permeabilized by nystatin treatment. Ca(2+)-regulated...
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Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein

Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ

  • KMID: 2154241
  • Exp Mol Med.
  • 2013 May;45(5):e22.
The accumulation of abnormal protein aggregates is a major characteristic of many neurodegenerative disorders, including Parkinson's disease (PD). The intracytoplasmic deposition of alpha-synuclein aggregates and Lewy bodies, often found in...
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Expression of Ca2+-dependent Synaptotagmin Isoforms in Mouse and Rat Parotid Acinar Cells

Jo H, Byun HM, Kim JH, Kim MS, Kim SH, Hong JH, Seo JT, Lee SI, Shin DM, Son HK

Synaptotagmin is a Ca2+ sensing protein, which triggers a fusion of synaptic vesicles in neuronal transmission. Little is known regarding the expression of Ca2+ - dependent synaptotagmin isoforms and their...
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Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet beta cells

Kalwat MA, Thurmond D

  • KMID: 2154256
  • Exp Mol Med.
  • 2013 Aug;45(8):e37.
The maintenance of whole-body glucose homeostasis is critical for survival, and is controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet beta cells secrete insulin in response...
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