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Peripheral Nerve Injury Alters Excitatory and Inhibitory Synaptic Transmission in Rat Spinal Cord Substantia Gelatinosa

Youn DH

  • KMID: 1600055
  • Korean J Physiol Pharmacol.
  • 2005 Jun;9(3):143-147.
Following peripheral nerve injury, excessive nociceptive inputs result in diverse physiological alterations in the spinal cord substantia gelatinosa (SG), lamina II of the dorsal horn. Here, I report the alterations...
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Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats

Yan WW, Yao LH, Chen C, Wang HX, Li CH, Huang JN, Xiao P, Liu CY

PURPOSE: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded...
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Inhibitory and Excitatory Postsynaptic Currents of Medial Vestibular Nucleus Neurons of Rats

Chun SW, Choi JH, Park BR

  • KMID: 2285272
  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):59-64.
The medial vestibular nucleus (MVN) neurons are controlled by excitatory synaptic transmission from the vestibular afferent and commissural projections, and by inhibitory transmission from interneurons. Spontaneous synaptic currents of MVN...
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Correlation between mEPSC Amplitude and Rise Time upon the Blockade of AMPA Receptor Desensitization at Hippocampal Synapses

Jung SH, Choi S

  • KMID: 1614994
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):81-86.
Conventional views of synaptic transmission generally overlook the possibility of "postfusional- control" the regulation of the speed or completeness of transmitter release upon vesicular fusion. However, such regulation often occurs...
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Long-Term Potentiation of Excitatory Synaptic Strength in Spinothalamic Tract Neurons of the Rat Spinal Cord

Hur SW, Park JM

Spinal dorsal horn nociceptive neurons have been shown to undergo long-term synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Here, we focused on the spinothalamic tract (STT) neurons...
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Pre- and Postsynaptic Actions of Reactive Oxygen Species and Nitrogen Species in Spinal Substantia Gelatinosa Neurons

Park A, Chun SW

Reactive oxygen species (ROS) and nitrogen species (RNS) are involved in cellular signaling processes as a cause of oxidative stress. According to recent studies, ROS and RNS are important signaling...
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Fluoxetine Modulates Corticostriatal Synaptic Transmission through Postsynaptic Mechanism

Cho HS, Choi SJ, Kim KJ, Lee HH, Cho YJ, Kim SY, Sung KW

  • KMID: 1512939
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):31-38.
Fluoxetine, widely used for the treatment of depression, is known to be a selective serotonin reuptake inhibitor (SSRI), however, there are also reports that fluoxetine has direct effects on several...
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Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro

Uta D, Hattori T, Yoshimura

PURPOSE: Naftopidil ((±)-1-[4-(2-methoxyphenyl) piperazinyl]-3-(1-naphthyloxy) propan-2-ol) is prescribed in several Asian countries for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Previous animal experiments showed that intrathecal injection of naftopidil...
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Roles of metabotropic glutamate receptors on excitatory synaptic transmission in rat trigeminal caudal neurons

Choi JH, Chae SC, Min SK, Chun SW

  • KMID: 1515870
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2004 Sep;26(5):461-468.
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn : MDH) is implicated in the processing of nociceptive information in the orofacial region. Whole cell patch clamp recordings...
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Influence of Potassium Channel Blockage on Early Hypoxic Neuronal Excitability

Kim JH, Moon HJ, Kim JH, Kwon TH, Chung HS, Park YK

OBJECTIVE: Potassium channels are ubiquitously expressed in all organisms and constitute the most diverse class of ion channels. Their action is regulated by various factors and is involved in neuronal...
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Intravenous Anesthetic, Propofol Affects Synaptic Responses in Cerebellar Purkinje Cells

Lee KY, Jang Y, Lee MH, Kim YI, Jung SC, Han SY, Kim SH, Park HS, Kim DK

OBJECTIVE: Propofol is an intravenously administered anesthetic that enhances γ-aminobutyric acid-mediated inhibition in the central nerve system. Other mechanisms may also be involved in general anesthesia. Propofol has been implicated...
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Echinacoside, an active constituent of Herba Cistanche, suppresses epileptiform activity in hippocampal CA3 pyramidal neurons

Lu CW, Huang SK, Lin TY, Wang SJ

Echinacoside, an active compound in the herb Herba Cistanche, has been reported to inhibit glutamate release. In this study, we investigated the effects of echinacoside on spontaneous excitatory synaptic transmission...
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Changes in Synaptic Transmission and Long-term Potentiation Induction as a Possible Mechanism for Learning Disability in an Animal Model of Multiple Sclerosis

Mosayebi G, Soleyman M, khalili M, Mosleh M, Palizvan M

PURPOSE: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. It has been shown that memory deficits is common in patients with MS. Recent studies...
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Characterization on Responsiveness of Excitatory Synaptic Transmissions to α1-Adrenoceptor Blockers in Substantia Gelatinosa Neurons Isolated From Lumbo-Sacral Level in Rat Spinal Cords

Uta D, Hattori T, Yoshimura

PURPOSE: The aim of this study was to characterize the responsiveness of miniature excitatory postsynaptic currents (mEPSCs) to α1-adrenoceptor blockers in substantia gelatinosa (SG) neurons from the spinal cord to...
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Evaluating the Extent of Ischemic Insult on Hippocampal Slices by Using Antidromic Recordings

Kim JH, Kwon TH, Chung HS, Park YK

OBJECTIVE: Energy failure and concurrent electrical silence are common features of oxygen-glucose deprivation (OGD) in the brain. Hippocampal slice has been used extensively to study electrophysiological alterations. Orthodromic extracellular field...
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5-Hydroxytryptamine Inhibits Glutamatergic Synaptic Transmission in Rat Corticostriatal Brain Slice

Cho HS, Choi SJ, Kim KJ, Lee HH, Kim SY, Cho YJ, Sung KW

  • KMID: 1600107
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):255-262.
Striatum is involved in the control of movement and habitual memory. It receives glutamatergic input from wide area of the cerebral cortex as well as an extensive serotonergic (5-hydroxytryptamine, 5-HT)...
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The effect of µ-opioid receptor activation on GABAergic neurons in the spinal dorsal horn

Kim YR, Shim HG, Kim CE, Kim SJ

The superficial dorsal horn of the spinal cord plays an important role in pain transmission and opioid activity. Several studies have demonstrated that opioids modulate pain transmission, and the activation...
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Forskolin Enhances Synaptic Transmission in Rat Dorsal Striatum through NMDA Receptors and PKA in Different Phases

Cho HS, Lee HH, Choi SJ, Kim KJ, Jeun SH, Li QZ, Sung KW

The effect of forskolin on corticostriatal synaptic transmission was examined by recording excitatory postsynaptic currents (EPSCs) in rat brain slices using the whole-cell voltage-clamp technique. Forskolin produced a dose-dependent increase...
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Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon

Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS

Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by...
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β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice

Ye JY, Li L, Hao QM, Qin Y, Ma CS

Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential...
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