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The Role of NMDA Receptor Antagonists in Nicotine Tolerance, Sensitization, and Physical Dependence: A Preclinical Review

Jain R, Mukherjee , Balhara YP

Nicotine, the primary psychoactive component of tobacco products, produces diverse neurophysiological, motivational, and behavioral effects through several brain regions and neurochemical pathways. Various neurotransmitter systems have been explored to understand...
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Antinociceptive Interactions between Intrathecal Gabapentin and MK801 or NBQX in Rat Formalin Test

Yoon MH, Bae HB, Choi JI

Antagonists for spinal N-methyl-D-aspartate (NMDA) and amino-hydroxy-methtyl-isoxazolepropionate (AMPA) receptors are effective in attenuating acute nociception or injury-induced hyperalgesia. The antinociception of spinal gabapentin is developed in injury-induced hyperalgesia without affecting...
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Immobilization with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus Monkeys

Lee JI, Hong SH, Lee SJ, Kim YS, Kim MC

  • KMID: 1089411
  • J Vet Sci.
  • 2003 Aug;4(2):187-191.
To compare the effects of ketamine and tiletaminezolazepam (TZ) drugs widely used for the chemical restraint and immobilization of primates, on various physiological parameters and blood gas values in cynomolgus...
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Effects of MK-801 and Morphine on Spinal C-Fos Expression during the Development of Neuropathic Pain

Lee YW, Park KA, Lee WT

The purpose of this study was to investigate the expression of c-fos in the spinal cord during the development of allodynia, induced by peripheral nerve injury. Following tight ligation of...
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