- The inhibitory effect of opioid on the hyperpolarization-activated cation currents in rat substantia gelatinosa neurons
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Seol GH, Kim J, Cho SH, Kim WK, Kim JW, Kim SJ
- KMID: 1607076
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):373-380.
The action of opioid on the hyperpolarization-activated cation current (Ih) in substantia gelatinosa neurons were investigated by using whole-cell voltage-clamp recording in rat spinal brain slices. Hyperpolarizing voltage steps revealed slowly activating currents... -
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- Inhibitory Mechanism of Periaqueductal Gray Matter on Neuropathic Pain in Rat
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Kim BO, Ryu JW, Seo JS, Sohn JH
- KMID: 2174649
- J Korean Acad Rehabil Med.
- 2001 Feb;25(1):110-116.
OBJECTIVE: Using Lee et al (1996) model, we assessed the effect of opioid within the PAG on the manifestations of the neuropathic pain, and we studied the effects of naloxone... -
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- Dual effect of dynorphin A on single-unit spike potentials in rat trigeminal nucleus
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Lee KM, Han HS, Jang JH, Ahn DK, Park JS
- KMID: 1606936
- Korean J Physiol Pharmacol.
- 2001 Jun;5(3):213-221.
The amygdala is known as a site for inducing analgesia, but its action on the trigeminal nucleus has not been known well. Little information is available on the effect of dynorphin on... -
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- DAMGO modulates two-pore domain K⺠channels in the substantia gelatinosa neurons of rat spinal cord
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Cho PS, Lee HK, Lee SH, Im JZ, Jung SJ
- KMID: 2350509
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):525-531.
- doi: 10.4196/kjpp.2016.20.5.525
The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying Kâº... -
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- Investigation of Orphanin FQ-stimulated [35S]GTPgammaS Binding in the Whole Brain of Mice: Does Orphanin FQ Have Anti-opioid Effect in the Level of Receptor-ligand Interaction and [35S]GTPgammaS Activation?
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Lee H, Lee EM
- KMID: 2238304
- Korean J Anesthesiol.
- 2007 Jul;53(1):91-96.
- doi: 10.4097/kjae.2007.53.1.91
BACKGROUND: This study was examined whether or not the orphanin FQ (OFQ)-stimulated [35S]GTPgammaS activity interact with DAMGO in the whole brain of mice. METHODS: ICR mice (male, n = 20,... -
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- The effect of µ-opioid receptor activation on GABAergic neurons in the spinal dorsal horn
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Kim YR, Shim HG, Kim CE, Kim SJ
- KMID: 2414266
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):419-425.
- doi: 10.4196/kjpp.2018.22.4.419
The superficial dorsal horn of the spinal cord plays an important role in pain transmission and opioid activity. Several studies have demonstrated that opioids modulate pain transmission, and the activation... -
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- Effects of Whole Body Irradiation on Morphine, DAMGO, DPDPE, U50,488H and beta-endorphin-Induced Antinociception
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Park TW, Kim JK, Jeong JS, Kim TW, Cho YK, Kim KN, Chung KM
- KMID: 2009493
- Int J Oral Biol.
- 2012 Mar;37(1):1-7.
Opioid receptors have been pharmacologically classified as micro, delta, kappa and epsilon. We have recently reported that the antinociceptive effect of morphine (a micro-opioid receptor agonist), but not that of... -
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- Studies of mu-, kappa-, and delta-Opioid Receptor Densities and G Protein Activation in Cerebral Membranes of Mice
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Lee HS
- KMID: 2299297
- Korean J Anesthesiol.
- 2004 Oct;47(4):574-579.
- doi: 10.4097/kjae.2004.47.4.574
BACKGROUND: The aim of this study was to investigate the relative densities of mu-, kappa-, and delta-opioid receptors (MOR, KOR, and DOR) and [35S]GTPgammaS binding as stimulated by full agonists... -
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- Effects of micron-Opioid Agonist on ATP-sensitive Potassium Channel Activity in Isolated Ventricular Cardiomyocytes
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Piao LH, Wu M, Kim JH
- KMID: 2172282
- Chonnam Med J.
- 2009 Apr;45(1):38-46.
- doi: 10.4068/cmj.2009.45.1.38
It is well known that opioid agonists are released from the myocardium during hypoxia or ischemia, and that ATP-sensitive potassium channels (K(ATP) channels) exist in the cardiac cell membrane and... -
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- DAMGO, a micro-opioid agonist and cholecystokinin-octapeptide have dual modulatory effects on capsaicin-activated current in rat dorsal root ganglion neurons
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Eun SY, Kim J, Lee J, Jung SJ, Park JM, Park YK, Kim D, Kim SJ, Kwak J, Kim J
- KMID: 1606841
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):71-78.
Capsaicin, a pungent ingredient of hot pepper, elicits an intense burning pain when applied cutaneously and intradermally. Activation of capsaicin-gated channel in. C-type dorsal root ganglion (DRG) neurons produces nonselective cationic currents. Although... -
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- The Effect of Mu Agonist on Seizure in Hippocampus
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Choi BJ, Kim JS
- KMID: 2007316
- J Korean Child Neurol Soc.
- 2001 Oct;9(2):289-296.
PURPOSE: Mu agonists can be used in clinical conditions where threr is a risk of hypoxic neurosusceptibility. Fentanyl, one of mu agonists may serve as neuroprotection from brain ischemic injury... -
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- Change of Hyperexcitability of Hippocampus by Cyclosporin A and Its Modulatory Action by Fentanyl
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Choi BJ, Whang KT
- KMID: 2157602
- J Korean Med Sci.
- 2002 Feb;17(1):96-102.
- doi: 10.3346/jkms.2002.17.1.96
Cyclosporin A is used to treat patients with immune-mediated diseases, chronic diseases requiring organ transplantation, or malignancies. These conditions often require higher cyclosporin A doses, which may be toxic to... -
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- STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance
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Kim YJ, Kang Y, Park HY, Lee JR, Yu DY, Murata T, Gondo Y, Hwang JH, Kim YH, Lee CH, Rhee M, Han PL, Chung BH, Lee HJ, Kim KS
- KMID: 2361499
- Exp Mol Med.
- 2016 Feb;48(2):e212.
- doi: 10.1038/emm.2016.1
Striatal-enriched protein tyrosine phosphatase (STEP) is abundantly expressed in the striatum, which strongly expresses dopamine and opioid receptors and mediates the effects of many drugs of abuse. However, little is... -
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