- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
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Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
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- In silico Screening of Chemical Libraries to Develop Inhibitors That Hamper the Interaction of PCSK9 with the LDL Receptor
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Min DK, Lee HS, Lee N, Lee CJ, Song HJ, Yang GE, Yoon D, Park SW
- KMID: 2163616
- Yonsei Med J.
- 2015 Sep;56(5):1251-1257.
- doi: 10.3349/ymj.2015.56.5.1251
PURPOSE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) and promotes degradation of the LDLR. Inhibition of PCSK9 either by reducing its expression or... -
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- Protease activity of 80 kDa protein secreted from the apicomplexan parasite Toxoplasma gondii
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Song KJ, Nam HW
- KMID: 1720474
- Korean J Parasitol.
- 2003 Sep;41(3):165-169.
- doi: 10.3347/kjp.2003.41.3.165
This study describes the characterization of 80 kDa protease showing gelationlytic property among three proteases in the excretory/secretory proteins (ESP) from Toxoplasma gondii. The protease activity was detected in the... -
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- Enhanced expression of cathepsin L in metastatic bone tumors
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Park IC, Lee SY, Jeon DG, Lee JS, Hwang CS, Hwang YG, Lee SH, Hong WS, Hong SI
- KMID: 644942
- J Korean Med Sci.
- 1996 Apr;11(2):144-148.
- doi: 10.3346/jkms.1996.11.2.144
Cathepsin L is a kind of cystein proteases which are known to facilitate the invasion and metastasis of tumor cells by degrading the components of basement membrane and extracellular matrix.... -
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- Granzyme B and TIA-1 Expression in Chronic and Acute on Chronic Renal Allograft Rejection
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Hong SW, Jeong HJ, Kim SI, Moon JI, Kim YS, Park K
- KMID: 720623
- Yonsei Med J.
- 2001 Jun;42(3):285-290.
- doi: 10.3349/ymj.2001.42.3.285
Although active inflammation may be deleterious and indicate immunologic activation in chronically rejected grafts, the underlying mechanism of tissue destruction has been little studied. Twenty-four cases of chronic rejection (CR)... -
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