- Nuclear receptor regulation of stemness and stem cell differentiation
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Jeong Y, Mangelsdorf DJ
- KMID: 1119318
- Exp Mol Med.
- 2009 Aug;41(8):525-537.
- doi: 10.3858/emm.2009.41.8.091
Stem cells include a diverse number of toti-, pluri-, and multi-potent cells that play important roles in cellular genesis and differentiation, tissue development, and organogenesis. Genetic regulation involving various transcription... -
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- Very small embryonic-like stem-cell optimization of isolation protocols: an update of molecular signatures and a review of current in vivo applications
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Shin DM, Suszynska , Mierzejewska K, Ratajczak , Ratajczak
- KMID: 2154275
- Exp Mol Med.
- 2013 Nov;45(11):e56.
As the theory of stem cell plasticity was first proposed, we have explored an alternative hypothesis for this phenomenon: namely that adult bone marrow (BM) and umbilical cord blood (UCB)... -
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- Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells
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Kwak DH, Yu K, Kim SM, Lee DH, Kim SM, Jung JU, Seo JW, Kim N, Lee SK, Jung KY, You H, Kim HA, Choo YK
- KMID: 1115945
- Exp Mol Med.
- 2006 Dec;38(6):668-676.
Stem cells are used for the investigation of developmental processes at both cellular and organism levels and offer tremendous potentials for clinical applications as an unlimited source for transplantation. Gangliosides,... -
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- Roles of gangliosides in mouse embryogenesis and embryonic stem cell differentiation
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Kwak DH, Seo BB, Chang KT, Choo YK
- KMID: 1015456
- Exp Mol Med.
- 2011 Jul;43(7):379-388.
- doi: 10.3858/emm.2011.43.7.048
Gangliosides have been suggested to play important roles in various functions such as adhesion, cell differentiation, growth control, and signaling. Mouse follicular development, ovulation, and luteinization during the estrous cycle... -
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- Enhancing effects of serum-rich and cytokine-supplemented culture conditions on developing blastocysts and deriving porcine parthenogenetic embryonic stem cells
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Jung SK, Kim HJ, Kim CL, Lee JH, You JY, Lee ES, Lim JM, Yun SJ, Song JY, Cha SH
- KMID: 2070238
- J Vet Sci.
- 2014 Dec;15(4):519-528.
- doi: 10.4142/jvs.2014.15.4.519
The present study was conducted to develop an effective method for establishment of porcine parthenogenetic embryonic stem cells (ppESCs) from parthenogenetically activated oocyte-derived blastocysts. The addition of 10% fetal bovine... -
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- Role of the epithelial-mesenchymal transition and its effects on embryonic stem cells
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Kim YS, Yi BR, Kim NH, Choi KC
- KMID: 2155373
- Exp Mol Med.
- 2014 Aug;46(8):e108.
- doi: 10.1038/emm.2014.44
The epithelial-mesenchymal transition (EMT) is important for embryonic development and the formation of various tissues or organs. However, EMT dysfunction in normal cells leads to diseases, such as cancer or... -
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- Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage
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Ji AR, Ku SY, Cho MS, Kim YY, Kim YJ, Oh SK, Kim SH, Moon SY, Choi YM
- KMID: 946650
- Exp Mol Med.
- 2010 Mar;42(3):175-186.
- doi: 10.3858/emm.2010.42.3.018
Recently, reactive oxygen species (ROS) have been studied as a regulator of differentiation into specific cell types in embryonic stem cells (ESCs). However, ROS role in human ESCs (hESCs) is... -
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- Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells
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Cho YM, Jang YS, Jang YM, Chung SM, Kim HS, Lee JH, Jeong SW, Kim IK, Kim JJ, Kim KS, Kwon OJ
- KMID: 756236
- Exp Mol Med.
- 2009 Jun;41(6):440-452.
- doi: 10.3858/emm.2009.41.6.049
When we treated rat bone marrow stromal cells (rBMSCs) with neuronal differentiation induction media, typical unfolded protein response (UPR) was observed. BIP/GRP78 protein expression was time-dependently increased, and three branches... -
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- The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells
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Jung JU, Ko K, Lee DH, Ko K, Chang KT, Choo YK
- KMID: 1099869
- Exp Mol Med.
- 2009 Dec;41(12):935-945.
- doi: 10.3858/emm.2009.41.12.099
Glycosphingolipids including gangliosides play important regulatory roles in cell proliferation and differentiation. UDP-glucose:ceramide glucosyltransferase (Ugcg) catalyze the initial step in glycosphingolipids biosynthesis pathway. In this study, Ugcg expression was reduced... -
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- Alterations of proliferative and differentiation potentials of human embryonic stem cells during long-term culture
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Park YB, Kim YY, Oh SK, Chung SG, Ku SY, Kim SH, Choi YM, Moon SY
- KMID: 1103593
- Exp Mol Med.
- 2008 Feb;40(1):98-108.
- doi: 10.3858/emm.2008.40.1.98
Human embryonic stem cells (hESCs) are considered to be able to stably maintain their characteristics in vitro for prolonged periods, but we had previously encountered changes in proliferative ability and... -
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