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D-Lactic Acidosis in Humans: Review of Update

Kang KP, Lee S, Kang SK

D-Lactic acidosis has been well documented in ruminants. In humans, D-lactic acidosis is very rare, but D-lactic acidosis may be more common than generally believed and should be looked for...
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Pathogenesis and Treatment of Dyskalemia in Maintenance Hemodialysis and CAPD

Kim HJ

In end-stage renal disease (ESRD) patients regardless of dialysis modes, i.e. maintenance hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD), potassium (K) homeostasis is regulated primarily via dialysis and extrarenal...
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Clinical Usefulness of the Serum Anion Gap

Lee S, Kang KP, Kang SK

The anion gap in the serum is useful in the interpretation of acid-base disorders and in the diagnosis of other conditions. In the early 1980s, ion-selective electrodes for specific ionic...
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Renal Interstitial Fibrosis and Angiotensin Inhibition

Koo JW

Tubulointerstitial (TI) fibrosis is a final common pathway to progressive renal injury of all forms of renal disease. However, once renal damage reaches a certain threshold, progression of renal disease...
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Dysregulation of ENaC in Animal Models of Nephrotic Syndrome and Liver Cirrhosis

Kim SW

Nephrotic syndrome and liver cirrhosis are common clinical manifestations, and are associated with avid sodium retention leading to the development of edema and ascites. However, the mechanism for the sodium...
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Long-Term Regulation of Renal Urea Transporters during Antidiuresis

Kim DU

To produce a concentrated urine, the renal medulla needs hypertonicity for the reabsorption of free water from collecting duct. The single effect that increases interstitial tonicity in the outer medulla...
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Introduction of Organic Anion Transporters (SLC22A) and a Regulatory Mechanism by Caveolins

Lee WK, Jung SM, Kwak JO, Cha SH

The kidney is an important organ for controlling the volume of body fluids, electrolytic balance and excretion/reabsorption of endogenous and exogenous compounds. Among these renal functions, excretion/reabsorption of endogenous and...
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Nitric Oxide Synthesis in the Adult and Developing Kidney

Han KH, Jung JY, Chung KY, Kim H, Kim J

Nitric oxide (NO) is synthesized within the adult and developing kidney and plays a critical role in the regulation of renal hemodynamics and tubule function. In the adult kidney, the...
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