- Resistance to Adefovir in Patients with Chronic Hepatitis B
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Ryu SH, Chung YH
- KMID: 938252
- Korean J Hepatol.
- 2006 Dec;12(4):484-492.
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- Impact of prior lamivudine use on the antiviral efficacy and development of resistance to entecavir in chronic hepatitis B patients
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Hwang JA, Kim KB, Yang MJ, Lim SG, Hwang JC, Cheong JY, Cho SW, Kim SS
- KMID: 2164363
- Clin Mol Hepatol.
- 2015 Jun;21(2):131-140.
- doi: 10.3350/cmh.2015.21.2.131
BACKGROUND/AIMS: To determine the efficacies of entecavir (ETV) in nucleos(t)ide analogue (NA)-naive chronic hepatitis B (CHB) patients and in those with prior lamivudine (LAM) use who did not develop resistance. METHODS:... -
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- Clinical and Virologic Characteristics of Lamivudine Resistance in HBV-associated Chronic Liver Disease
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Kim SS, Chung MG, Ju KT, Park DK, Kwon OS, Koo YS, Kim YK, Choi DJ, Hwang YJ, Kim JH
- KMID: 863116
- Korean J Hepatol.
- 2002 Dec;8(4):405-417.
BACKGROUND/AIMS: Lamivudine therapy in chronic hepatitis B has been shown to be effective in inhibiting HBV replication. However, lamivudine resistance has been developed with prolonged use. We studied to... -
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- Genotypic resistance to entecavir in chronic hepatitis B patients
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Kim BU, Goo JC, Park BC, Kim SO, Hong SP, Jeong JI, Chae HB, Park SM, Youn SJ
- KMID: 1792593
- Korean J Hepatol.
- 2010 Jun;16(2):147-157.
- doi: 10.3350/kjhep.2010.16.2.147
BACKGROUND/AIMS: The prevalence and clinical characteristics of entecavir (ETV) resistance is not well known. The aim of this study was to determine the frequency of genotypic resistance in nonresponders and... -
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- Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine-resistant chronic hepatitis B patients
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Cho JH, Cheong JY, Kang JK, Park JS, Lee MH, Lim NK, Hong SP, Kim SO, Yoo WD, Cho SW
- KMID: 1073330
- Korean J Hepatol.
- 2008 Mar;14(1):58-66.
- doi: 10.3350/kjhep.2008.14.1.58
BACKGROUND/AIMS: Adefovir dipivoxil (adefovir) effectively inhibits both wild-type and lamivudine-resistant hepatitis B virus (HBV) replication. The development of adefovir resistance is both delayed and infrequent compared with lamivudine resistance.... -
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- Long-term outcomes of two rescue therapies in lamivudine-refractory patients with chronic hepatitis B: combined lamivudine and adefovir, and 1-mg entecavir
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Ze E, Baek EK, Lee JJ, Chung HW, Ahn DG, Cho HJ, Kwon JC, Kim HJ, Lee H
- KMID: 2069763
- Clin Mol Hepatol.
- 2014 Sep;20(3):267-273.
- doi: 10.3350/cmh.2014.20.3.267
BACKGROUND/AIMS: Adefovir (ADV) and lamivudine (LAM) combination therapy (ADV+LAM) has been a useful option for patients with LAM-resistant (LAM-r) chronic hepatitis B (CHB). However, the long-term outcomes of LAM+ADV and... -
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- Long-Term Outcomes and Dynamics of Mutants Associated with Lamivudine-Adefovir Rescue Therapy in Patients with Lamivudine-Resistant Chronic Hepatitis B
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Kim J, Lee SH, Kim HS, Choi K, Jeong SW, Kim SG, Jang JY, Kim YS, Kim BS
- KMID: 2380789
- Gut Liver.
- 2015 Jan;9(1):103-108.
- doi: 10.5009/gnl14018
BACKGROUND/AIMS: To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination... -
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- Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
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Kim JH, Jung YK, Joo MK, Kim JH, Yim HJ, Park JJ, Kim JS, Bak YT, Yeon JE, Byun KS
- KMID: 1779257
- J Korean Med Sci.
- 2010 Feb;25(2):257-264.
- doi: 10.3346/jkms.2010.25.2.257
The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated... -
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- Continuous Long-Term Entecavir Therapy in Naive Chronic Hepatitis B Patients Showing Partial Virologic Response
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Kwon DH, Kim IH, Choung BS, Ahn DS, Yoo SH, Park SB, Lee S, Kim SH, Kim SW, Im YJ
- KMID: 1712332
- Gut Liver.
- 2013 Nov;7(6):712-718.
BACKGROUND/AIMS: We investigated the efficacy of continuous long-term entecavir 0.5 mg treatment in naive chronic hepatitis B patients showing a partial virologic response (PVR). METHODS: A total of 227 patients were... -
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- Entecavir to Telbivudine Switch Therapy in Entecavir-Treated Patients with Undetectable Hepatitis B Viral DNA
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Kim DH, Choi JW, Seo JH, Cho YS, Won SY, Park BK, Jeon HH, Shin SY, Lee CK
- KMID: 2419112
- Yonsei Med J.
- 2017 May;58(3):552-556.
- doi: 10.3349/ymj.2017.58.3.552
PURPOSE: This study examined 2-year outcome of consecutive therapy using entecavir (ETV) followed by telbivudine (LdT) in subjects with undetectable hepatitis B virus (HBV) DNA level and normal alanine aminotransferase... -
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- HBsAg level and clinical course in patients with chronic hepatitis B treated with nucleoside analogue: five years of follow-up data
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Kim JH, Choi YJ, Moon HW, Ko SY, Choe WH, Kwon SY
- KMID: 1730887
- Clin Mol Hepatol.
- 2013 Dec;19(4):409-416.
- doi: 10.3350/cmh.2013.19.4.409
BACKGROUND/AIMS: Quantification of the hepatitis B surface antigen (HBsAg) is increasingly used to determine the treatment response in patients with chronic hepatitis B (CHB). However, there are limited data about... -
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- Long-term efficacy of tenofovir disoproxil fumarate therapy after multiple nucleos(t)ide analogue failure in chronic hepatitis B patients
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Kim HJ, Cho JY, Kim YJ, Gwak GY, Paik YH, Choi MS, Koh KC, Paik SW, Yoo BC, Lee JH
- KMID: 2129661
- Korean J Intern Med.
- 2015 Jan;30(1):32-41.
- doi: 10.3904/kjim.2015.30.1.32
BACKGROUND/AIMS: The efficacy of tenofovir disoproxil fumarate (TDF) for the treatment of chronic hepatitis B (CHB) patients following prior treatment failure with multiple nucleos(t)ide analogues (NAs) is not well defined,... -
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- Molecular Epidemiology of Hepatitis B Virus
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Kao JH
- KMID: 1022164
- Korean J Intern Med.
- 2011 Sep;26(3):255-261.
- doi: 10.3904/kjim.2011.26.3.255
Although safe and effective vaccines for hepatitis B virus (HBV) have been available for nearly three decades, this virus kills at least 600,000 people annually worldwide and remains the leading... -
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- Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study
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Cho EY, Yim HJ, Jung YK, Suh SJ, Seo YS, Kim JH, Kim HS, Lee SH, Ahn SH, Lee JI, Jeong SH, Kim JW, Lee JW, Kim IH, Kim HS, Park SJ, Lee JM, Hwang SG
- KMID: 2412164
- Gut Liver.
- 2017 Jan;11(1):129-135.
- doi: 10.5009/gnl15597
BACKGROUND/AIMS: Data are lacking regarding the management of chronic hepatitis B (CHB) with resistance to clevudine (CLV). This study evaluated the efficacy of different rescue therapies for CLV-resistant CHB. METHODS: Patients... -
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- Natural YMDD Motif Mutations of HBV Polymerase in the Chronic Hepatitis B Virus Infected Patients
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Shin YM, Cho M, Heo J, Kim GH, Kang DH, Song GA, Yang US, Kim CM, Park HK, Jang HJ
- KMID: 1011389
- Korean J Hepatol.
- 2003 Mar;9(1):1-9.
BACKGROUND/AIMS: Lamivudine, a nucleoside analogue has been widely used as an effective antiviral agent for the treatment of patients with chronic hepatitis B infection. However, the YMDD motif mutation... -
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- Mutations within the interferon sensitivity determining region in Korean patients infected with hepatitis C virus genotype 1b
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Jin YJ, Park YK, Yun GJ, Lee HC, Jeong SH, Kim GM, Lim YS, Chung YH, Lee YS, Suh DJ
- KMID: 1792594
- Korean J Hepatol.
- 2010 Jun;16(2):158-167.
- doi: 10.3350/kjhep.2010.16.2.158
BACKGROUND/AIMS: The treatment response to interferon could differ with mutations in the interferon-sensitivity-determining region (ISDR) in patients infected with hepatitis C virus (HCV) genotype-1b (HCV-Ib). We examined the pattern of... -
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