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A review of three years' experience of the first pharmacometrics company in Korea

Lee SJ, Jeon S

As the pharmaceutical industry in Korea is reaching the golden era of drug discovery due to increased investments in research and development and government funds, the need for a more...
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Comparison of Appropriate Piperacillin/Tazobactam Doses in Korean Obese Patients with Cancer Based on Different Body Size Descriptor Equations in a Tertiary Care Hospital

Kim JH, Yang YM, Yoon H, Cho EJ

BACKGROUND: Piperacillin/tazobactam (TZP) is an antibiotic against a broad spectrum of gram-positive, gram-negative, and aerobic and anaerobic strains of bacteria. Due to changes in its pharmacokinetic and pharmacodynamic parameters by...
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From Bench to Market: Preparing Human Pluripotent Stem Cells Derived Cardiomyocytes for Various Applications

Moon SH, Bae D, Jung TH, Chung EB, Jeong YH, Park SJ, Chung HM

Human cardiomyocytes (CMs) cease to proliferate and remain terminally differentiated thereafter, when humans reach the mid-20s. Thus, any damages sustained by myocardium tissue are irreversible, and they require medical interventions...
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Medical Representatives' Intention to Use Information Technology in Pharmaceutical Marketing

Kwak ES, Chang H

OBJECTIVES: Electronic detailing (e-detailing), the use of electronic devices to facilitate sales presentations to physicians, has been adopted and expanded in the pharmaceutical industry. To maximize the potential outcome of...
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Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury

Kim SH, Naisbitt D

Drug-induced liver injury (DILI) is a major concern for public health, as well as for drug development in the pharmaceutical industry, since it can cause liver failure and lead to...
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Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells

Lee HS, Kim EJ, Kim SH

BACKGROUND/OBJECTIVES: Inonotus obliquus (I. obliquus, Chaga mushroom) has long been used as a folk medicine to treat cancer. In the present study, we examined whether or not ethanol extract of...
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The Korean Pharmaceutical Industry and the Expansion of the General Pharmaceuticals Market in the 1950-1960s*

Sihn KH

After the Liberation, the Korean economy was dependent on relief supplies and aid after the ruin of the colonial regime and war. The pharmaceutical business also searched for their share...
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Foreign direct investment of Covidien Center of Innovation in medical device industry

Lee SS, Lee MY

Medical device industry has characteristics of multi-disciplinary convergence and is easy to apply with information communication technology. Such nature makes Korea medical device industry more globally competitive than the pharmaceutical...
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Current status of production and market of human vaccine products in Korea

Kim SY, Cho J, Cha SH, Bae CW

PURPOSE: The goal of this study was to build basic information related to the production and market of human vaccine products in Korea, which can be an important indicator to...
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Establishment and Significance of Bioequivalence Recommendations for Individual Products-Drugs Acting on Circulatory System and Others

Bae SH, Zheng YF, Kwon MJ, Choi EJ, Bae SK

  • KMID: 2334541
  • J Korean Soc Clin Pharmacol Ther.
  • 2013 Jun;21(1):17-25.
Along with the enactment of a law separating the prescribing and dispensing of drugs in Korea in 2000, attempts at reducing medical expenses by generic substitution have been allowed since...
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Current status of healthcare and effective health aid strategies in North Korea

Park SM, Lee HW

  • KMID: 2342157
  • J Korean Med Assoc.
  • 2013 May;56(5):368-374.
As the period since the partition of North and South Korea has been prolonged, the gap between the two Koreas continues to widen in various ways. Indeed, in the health...
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The antidiabetic effects of an herbal formula composed of Alnus hirsuta, Rosa davurica, Acanthopanax senticosus and Panax schinseng in the streptozotocin-induced diabetic rats

Hu W, Yeo JH, Jiang Y, Heo SI, Wang MH

  • KMID: 2391961
  • Nutr Res Pract.
  • 2013 Apr;7(2):103-108.
A folk prescription consisting of Alnus hirsuta, Rosa davurica, Acanthopanax senticosus and Panax schinseng has been used in the treatment of diabetes mellitus. The aim of the present investigation was...
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Medical ethics and self-regulation in Korean medical society

Koh Y

Consumption of medical services has been expanding since the health insurance system was established in the Republic of Korea. However, physicians do not seem to be satisfied with the current...
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MicroSPECT and MicroPET Imaging of Small Animals for Drug Development

Jang BS

  • KMID: 2317809
  • Toxicol Res.
  • 2013 Mar;29(1):1-6.
The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and...
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Curcumin, the Main Part of Turmeric, Prevents Learning and Memory Changes Induced by Sodium Metabisulfite, a Preservative Agent, in Rats

Noorafshan A, Asadi-Golshan R, Karbalay-Doust S, Abdollahifar MA, Rashidiani-Rashidabadi A

Sodium metabisulfite is used as a disinfectant, antioxidant, and preservative agent in the food, beverage, and drug industries. Neurons are highly sensitive to sulfite toxicity. Curcumin is the main part...
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Curcumin Can Prevent the Changes in Cerebellar Structure and Function Induced by Sodium Metabisulfite in Rat

Noorafshan A, Rashidiani-Rashidabadi A, Karbalay-Doust S, Poostpasand A, Abdollahifar MA, Asadi-Golshan R

Sulfites are used as anti-microbial and anti-oxidant agents in the food and pharmaceutical industries. Curcumin, a flavonoid, is an Asian spice that shows neuroprotective activities. The current study aimed to...
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Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells

Chung MJ, Kim JM, Lee S, Kim T, Kim D, Baek J, Kim T, Lee J, Kim K, Yoon JA, Choe M

  • KMID: 2313580
  • Nutr Res Pract.
  • 2012 Apr;6(2):97-105.
Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its...
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The Appropriate Interpretation of Recent Clinical Trials: How to Read RCT in the Era of Advertizing-based Medicine

Kuwajima I

Although evidence-based medicine (EBM) has changed medical therapy from experience- or experiment-based medicine to the modern science-based medicine, nowadays it seems to be used as a tool of advertizing strategy...
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Banding the World Together; The Global Growth of Control Banding and Qualitative Occupational Risk Management

Zalk DM, Heussen GH

  • KMID: 2317035
  • Saf Health Work.
  • 2011 Dec;2(4):375-379.
Control Banding (CB) strategies to prevent work-related illness and injury for 2.5 billion workers without access to health and safety professionals has grown exponentially this last decade. CB originates from...
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Medical device clinical trial

Hong SH

The development of new drugs and medical devices has been attributed to constant innovation, and the medical device industry in particular is growing faster than the drug industry. The medical...
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