- Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line
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Han JA, Park SC
- KMID: 1029936
- Exp Mol Med.
- 1999 Jun;31(2):83-88.
Increased expression of Transglutaminases 2 (TGase 2, TGase C) was observed in PC-14 human lung cancer cells in association with doxorubicin resistance and the reduction of the enzyme expression was correlated with... -
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- Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
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Jang JY, Kim MK, Jeon YK, Joung YK, Park KD, Kim CW
- KMID: 1365902
- Exp Mol Med.
- 2012 Apr;44(4):251-259.
- doi: 10.3858/emm.2012.44.4.019
Cancer stem cells (CSCs) are resistant to chemo- and radio-therapy, and can survive to regenerate new tumors. This is an important reason why various anti-cancer therapies often fail to completely... -
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- Transforming variant of Met receptor confers serum independence and anti-apoptotic property and could be involved in the mouse thymic lymphomagenesis
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Baek CM, Jeon SH, Jang JJ, Lee BS, Lee JH
- KMID: 1094072
- Exp Mol Med.
- 2004 Aug;36(4):283-291.
Met tyrosine kinase receptor, the receptor of hepatocyte growth factor/scatter factor (HGF/SF), is present in mouse tissues as two major isoforms differing by a 47-aminoacid segment in the juxtamembrane domain... -
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- Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells
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Jung EJ, Kim CW, Kim DR
- KMID: 756329
- Exp Mol Med.
- 2008 Jun;40(3):276-285.
- doi: 10.3858/emm.2008.40.3.276
Tropomyosin-related kinase A (TrkA) plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types. Here we show that TrkA overexpression by the Tet-On... -
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- Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability
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Lee W, Choi HI, Kim MJ, Park SY
- KMID: 1103594
- Exp Mol Med.
- 2008 Feb;40(1):109-117.
- doi: 10.3858/emm.2008.40.1.109
The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the carcinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not... -
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- Cloning of adriamycin-resistant related (arr) gene in an adriamycin-resistant L1210 variant
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Kim JR, Kim SY, Kim JH
- KMID: 1109297
- Exp Mol Med.
- 1998 Sep;30(3):145-149.
A partial fragment of novel sequence (arr, adriamycin-resistant related) was previously identified using the differential display (DD)-PCR technique with adriamycin-resistant L1210 variant (L1210AdR), which shows a typical multidrug resistant (MDR)... -
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