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Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels

Noh J, Chung JM

Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state...
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Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production

Chen D, Zhang XY, Sun J, Cong QJ, Chen WX, Ahsan HM, Gao J, Qian JJ

This study sought to evaluate the effects of Asiatic acid in LPS-induced BV2 microglia cells and 1-methyl-4-phenyl-pyridine (MPP⁺)-induced SH-SY5Y cells, to investigate the potential anti-inflammatory mechanisms of Asiatic acid in...
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Neurogenesis and neuronal migration of dopaminergic neurons during mesencephalon development in mice

Kim MK, Lee SJ, Vasudevan , Won C

Dopaminergic neurons are one of the major neuronal components in the brain. Mesencephalon dopamine (DA) neurogenesis takes place in the ventricular zone of the floor plate, when DA progenitors divide...
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Regional difference in spontaneous firing inhibition by GABA(A) and GABA(B) receptors in nigral dopamine neurons

Kim Y, Jang J, Kim HJ, Park MK

GABAergic control over dopamine (DA) neurons in the substantia nigra is crucial for determining firing rates and patterns. Although GABA activates both GABA(A) and GABA(B) receptors distributed throughout the somatodendritic...
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Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo

Bok E, Cho EJ, Chung ES, Shin WH, Jin BK

The present study investigated the effects of interleukin (IL)-4 on dopamine (DA) neurons in the substantia nigra (SN) in vivo of lipopolysaccharide (LPS)-treated rat. Tyrosine hydroxylase immunohistochemistry showed a significant...
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Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo

Kim S, Moon GJ, Oh YS, Park J, Shin WH, Jeong JY, Choi KS, Jin BK, Kholodilov N, Burke RE, Kim HJ, Ha CM, Lee SG, Kim SR

We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to...
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MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation

Lee S, Oh ST, Jeong HJ, Pak SC, Park HJ, Kim J, Cho HS, Jeon S

Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this...
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A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities

Jang Y, Lee MJ, Han J, Kim SJ, Ryu I, Ju X, Ryu MJ, Chung W, Oh E, Kweon GR, Heo JY

Movement defects in obesity are associated with peripheral muscle defects, arthritis, and dysfunction of motor control by the brain. Although movement functionality is negatively correlated with obesity, the brain regions...
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In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns

Kim T, Song JJ, Puspita L, Valiulahi , Shim JW, Lee SH

Developmental information aids stem cell biologists in producing tissue-specific cells. Recapitulation of the developmental profile of a specific cell type in an in vitro stem cell system provides a strategy...
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Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease

Chung YC, Baek JY, Kim SR, Ko HW, Bok E, Shin WH, Won SY, Jin BK

The effects of capsaicin (CAP), a transient receptor potential vanilloid subtype 1 (TRPV1) agonist, were determined on nigrostriatal dopamine (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease...
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Effects of Gypenosides on Dopaminergic Neuronal Cell Death in 6-Hydroxydopamine-lesioned Rat Model of Parkinson's Disease with Long-term L-DOPA Treatment

Shin KS, Zhao TT, Park HJ, Kim KS, Choi HS, Lee MK

The goal of this study was to determine whether gypenosides (GPS) exert protective effects against dopaminergic neuronal cell death in a 6-hydroxydopamine (OHDA)-lesioned rat model of Parkinson's disease (PD) with...
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CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease

Chung YC, Shin WH, Baek JY, Cho EJ, Baik HH, Kim SR, Won SY, Jin BK

The cannabinoid (CB2) receptor type 2 has been proposed to prevent the degeneration of dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. However, the mechanisms underlying CB2 receptor-mediated neuroprotection in MPTP mice...
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FGF8 is Essential for Functionality of Induced Neural Precursor Cell-derived Dopaminergic Neurons

Lim MS, Lee SY, Park CH

Induced neural precursor cells (iNPCs) are one source of transplantable dopaminergic neurons used in cell therapy for Parkinson's disease. In the present study, we demonstrate that iNPCs can be generated...
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Glucose Levels in Culture Medium Determine Cell Death Mode in MPP+-treated Dopaminergic Neuronal Cells

Yoon SY, Oh YJ

We previously demonstrated that 1-methyl-4-phenylpyridinium (MPP+) causes caspase-independent, non-apoptotic death of dopaminergic (DA) neuronal cells. Here, we specifically examined whether change of glucose concentration in culture medium may play a...
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Direct Differentiation of Adult Ocular Progenitors into Striatal Dopaminergic Neurons

Ahmad I, Zhao X, Parameswaran S, Destache C, Rodriguez-Sierra J, Thoreson W, Ahmad H, Sorrentino J, Balasubramanian S

Parkinson's disease, characterized by motor dysfunction due to the loss of nigrostriatal dopaminergic neurons, is one of the most prevalent age-related neurodegenerative disorders. Given there is no current cure, the...
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Protective Effects of Epigallocatechin-3-gallate against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death

Noh HG, Jang S, Park SJ, Kim SH, Jeong HS, Park JS

  • KMID: 2274899
  • Chonnam Med J.
  • 2007 Aug;43(2):73-79.
1-methyl-4-phenylpyridinium (MPP+) is a neurotoxin that selectively inhibits the mitochondrial functions of dopaminergic neurons in the substantia nigra pars compacta. MPP+ administration is accepted as in vivo and in vitro...
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1alpha,25-Dihydroxyvitamin D3 Protects Dopaminergic Neurons in Rodent Models of Parkinson's Disease through Inhibition of Microglial Activation

Kim JS, Ryu SY, Yun I, Kim WJ, Lee KS, Park JW, Kim YI

BACKGROUND: Recent studies have demonstrated the molecular basis of the immunomodulatory and anti-inflammatory activities of 1,25-dihydroxyvitamin D3(1,25-(OH)2D3). This hormone improves behavioral deficits and normalizes the nigral dopamine levels in animal...
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The Effect of 1, 25-Dihydroxyvitamin D3 on Dopaminergic Neurons and Microglial Activation in Parkinsonian Rat Model Induced by 6-Hydroxydopamine

Ryu SY, Kim JS, Choi YB, Han SR, Park JW, Park SK, Kim YI

  • KMID: 1626910
  • J Korean Neurol Assoc.
  • 2005 Jun;23(3):368-373.
BACKGROUND: Recent studies have shown increasing evidence for microglial activation in neuronal degeneration in Parkinson's disease (PD), although the cause of PD remains unclear. Recent studies have also shown that...
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Increased Poly (ADP-ribose) Polymerase Activation in the 6-Hydroxydopamine Induced Dopaminergic Neuronal Cell Death

Kang JH, Kang SY, Park SY, Kang HK, Park DB, Lee YK, Koh JY

  • KMID: 2343084
  • J Korean Neurol Assoc.
  • 2004 Aug;22(4):352-359.
BACKGROUND: The pathological hallmark of Parkinson's disease (PD) is dopaminergic cell death in the substantia nigra (SN), but the cause of cell death is unknown. 6-Hydroxydopamine (6-OHDA) is one of...
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Efficacy of Embryonic Stem Cell-derived Dopaminergic Neurons and E12 Mesencephalic Neuronal-precursor Derived Dopaminergic Neurons as a Source for Transplantation in Parkinsonian Rats

Koh HC, Park CH, Jeon BS, Lee SH

  • KMID: 2195076
  • J Korean Neurol Assoc.
  • 2003 Jun;21(3):289-296.
BACKGROUND: This study was performed to compare efficiency of embryonic stem (ES) cell-derived dopaminergic (DA) neurons from E12 mesencephalic neuronal-precursor derived DA neuron, and to assess the value of these...
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