- Comparative Effects of Ibandronate and Paclitaxel on Immunocompetent Bone Metastasis Model
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Chung YS, Kang HC, Lee T
- KMID: 2345895
- Yonsei Med J.
- 2015 Nov;56(6):1643-1650.
- doi: 10.3349/ymj.2015.56.6.1643
PURPOSE: Bone metastasis invariably increases morbidity and mortality. This study compares the effects of ibandronate and paclitaxel on bone structure and its mechanical properties and biochemical turnover in resorption markers... -
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- Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation
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Moon MH, Jeong JK, Seo JS, Seol JW, Lee YJ, Xue M, Jackson CJ, Park SY
- KMID: 1109402
- Exp Mol Med.
- 2011 Mar;43(3):138-145.
- doi: 10.3858/emm.2011.43.3.016
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant... -
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- Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates
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Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY
- KMID: 2154228
- Exp Mol Med.
- 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the... -
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- Preventive Effects of Zoledronic Acid on Bone Metastasis in Mice Injected with Human Breast Cancer Cells
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Jeong J, Lee KS, Choi YK, Oh YJ, Lee HD
- KMID: 1786012
- J Korean Med Sci.
- 2011 Dec;26(12):1569-1575.
- doi: 10.3346/jkms.2011.26.12.1569
Bisphosphonates are used routinely to reduce bone-related events in breast cancer patients with bone metastasis. We evaluated the effects of zoledronic acid, a third generation, nitrogen-containing bisphosphonate, to prevent bone... -
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- High Concentrations of Pamidronate in Bone Weaken the Mechanical Properties of Intact Femora in a Rat Model
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Yang KH, Won JH, Yoon HK, Ryu JH, Choo KS, Kim JS
- KMID: 2158171
- Yonsei Med J.
- 2007 Aug;48(4):653-658.
- doi: 10.3349/ymj.2007.48.4.653
PURPOSE: Bisphosphonates have been used to treat osteoporosis for more than ten years. However, complications associated with long-term administration of bisphosphonates, such as nonunion after pelvic insufficiency fracture or osteonecrosis... -
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- Genetic Polymorphism of Geranylgeranyl Diphosphate Synthase (GGSP1) Predicts Bone Density Response to Bisphosphonate Therapy in Korean Women
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Choi HJ, Choi JY, Cho SW, Kang D, Han KO, Kim SW, Kim SY, Chung YS, Shin CS
- KMID: 1126023
- Yonsei Med J.
- 2010 Mar;51(2):231-238.
- doi: 10.3349/ymj.2010.51.2.231
PURPOSE: Genetic factor is an important predisposing element influencing the susceptibility to osteoporosis and related complications. The purpose of the present study is to investigate whether genetic polymorphisms of farnesyl... -
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