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Roles of Serotonergic and Adrenergic Receptors in the Antinociception of Selective Cyclooxygenase-2 Inhibitor in the Rat Spinal Cord

Jeong HJ, Lee SH, Cho SY, Lee CS, Jeong CW, Yoon MH, Kim WM

BACKGROUND: The analgesic mechanisms of cyclooxygenase (COX)-2 inhibitors have been explained mainly on the basis of the inhibition of prostaglandin biosynthesis. However, several lines of evidence suggest that their analgesic...
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Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat

Lin H, Lee HG, Yoon MH

  • KMID: 1797467
  • Anesth Pain Med.
  • 2014 Apr;9(2):93-97.
BACKGROUND: Tianeptine is an antidepressant drug which is used for treating depression. Interestingly, the tianeptine has shown antinociceptive effects within a variety of nociceptions. The aim of this study is...
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Roles of Adenosine and Serotonin Receptors on the Antinociception of Sildenafil in the Spinal Cord of Rats

Lee HG, Kim WM, Park CH, Yoon MH

PURPOSE: The phosphodiesterase 5 inhibitor sildenafil has antinociceptive effects, mediated by an increase in cGMP. This study examined the role of spinal adenosine and serotonin receptors played in the antinociceptive...
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Spinal Gabapentin and Antinociception: Mechanisms of Action

Yoon MH, Choi JI, Jeong SW

Spinal gabapentin has been known to show the antinociceptive effect. Although several assumptions have been suggested, mechanisms of action of gabapentin have not been clearly established. The present study was...
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