- A Case of 17alpha-Hydroxylase Deficiency
-
Lee YK, Kang YJ, Pak CY, Choi SY, Park MS
- KMID: 2104264
- J Korean Pediatr Soc.
- 1996 Apr;39(4):577-584.
A 12-year-old girl with hypertension, hypokalemia, cystic ovaries and absence of secondary sexual development is presented. Hormonal study revealed very low levels of cortisol, testosterone, estrogen, and high levels of... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of tyrosine kinases in vascular contraction in deoxycorticosterone acetate-salt hypertensive rats
-
Yeum CH, Jun JY, Choi HS
- KMID: 1554765
- Korean J Physiol Pharmacol.
- 1997 Oct;1(5):547-553.
It has been known that activation of tyrosine kinases is involved in signal transduction. Role of the tyrosine kinase in vascular smooth muscle contraction was examined in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Male... -
- CITED
-
- Close
- SHARE
-
- Close
- Upregulation of Heat Shock Proteins in the Kidney in Hypertension
-
Lee G, Oh Y, Lee J
- KMID: 2285299
- Korean J Physiol Pharmacol.
- 2004 Jun;8(3):147-151.
The present study was undertaken to determine the regulation of heat shock proteins (HSP) in the kidney in hypertension. Two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA) -salt hypertension was... -
- CITED
-
- Close
- SHARE
-
- Close
- Coordinate expression of renin and cyclooxygenase-2 in rats with two-kidney, one clip and deoxycorticosterone acetate-salt hypertension
-
Lee JU, Oh YW, Kim S
- KMID: 1606947
- Korean J Physiol Pharmacol.
- 2001 Jun;5(3):253-258.
The present study was aimed to examine whether the expression of renin is associated with that of cyclooxygenase-2 (COX-2) in the kidney. Male Sprague-Dawley rats were made two-kidney, one clip (2K1C) or deoxycorticosterone... -
- CITED
-
- Close
- SHARE
-
- Close
- Diminished vascular guanylyl cyclase activity in deoxycorticosterone acetate-salt hypertension
-
Lee JU, Hong JH
- KMID: 1580935
- Korean J Physiol Pharmacol.
- 2000 Oct;4(5):379-383.
Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway in hypertension were investigated. Sprague-Dawley rats were made deoxycorticosterone acetate (DOCA)-salt hypertensive for six weeks. The protein expression of endothelial constitutive NO synthase (ecNOS) and... -
- CITED
-
- Close
- SHARE
-
- Close
- Altered renal nitric oxide system in experimental hypertensive rats
-
Yang ES, Kang J, Lee DG
- KMID: 2285208
- Korean J Physiol Pharmacol.
- 1998 Aug;2(4):455-460.
The present study was aimed at investigating whether the development of hypertension is related with an altered expression of nitric oxide synthases (NOS) in the kidney. By Western blot analysis, the expression of... -
- CITED
-
- Close
- SHARE
-
- Close
- Altered Calcium Current of the Vascular Smooth Muscle in Renal Hypertension
-
Nam SC, Jeong HJ, Kim W, Lee J
- KMID: 2285229
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):351-356.
The present study was aimed at investigating whether the calcium current in the vascular smooth muscle (VSM) cells is altered in renal hypertension. Two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension were... -
- CITED
-
- Close
- SHARE
-
- Close
- Enhanced Expression of Aldosterone Synthase and Adrenomedullin in Left and Right Ventricular Hypertrophy in Rats
-
Lee JU, Lee S, Kim S, Lee WJ
- KMID: 1615003
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):121-126.
The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Tempol on Blood Pressure and Tissue Oxidative Stress in DOCA-alt and L-AME-nduced Hypertension
-
Cho YW, Cho JW, Bae EH, Kim SW, Ma SK, Choi KC, Lee J
- KMID: 1597797
- Korean J Nephrol.
- 2006 Jul;25(4):525-531.
BACKGROUND: Effects of oxidative stress on the development of deoxycorticosterone acetate (DOCA)-salt or N(G)-nitro-L-arginine (L-NAME) hypertension were examined. METHODS: Male Sprague-awley rats were treated with DOCA (200 mg/kg, subcutaneous)-salt or L-NAME... -
- CITED
-
- Close
- SHARE
-
- Close
- Tissue-specific regulation of angiotensinogen and angiotensin II receptor gene expression in deoxycorticosterone acetate-salt hypertensive rats
-
Lee JU, An MR
- KMID: 2285225
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):315-320.
Molecular regulation of the renin-angiotensin system (RAS) was investigated in deoxycorticosterone acetate (DOCA)-salt hypertension. The expression of renin, angiotensinogen and angiotensin II receptor genes in the kidney and liver was determined by Northern... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of Primary Amenorrhea due to 17 -Hydroxylase Deficiency
-
Rim HS, Lee SH, Hong JM, Nam JH, Park HB, An CW, Ki DM, Lim SK, Song YD, Lee HC, Huh KB, Kang IS
- KMID: 2331163
- J Korean Soc Endocrinol.
- 2001 Feb;16(1):130-133.
17 -Hydroxylase deficiency is a rare form of congenital adrenal hyperplasia that is characterized by primary amenorrhea, absence of secondary sex characteristics, hypertension, and a hypokalemic alkalosis that has resulted... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of norepinephrine and neuropeptide Y on the contractility of small mesenteric artery from 2K1C and DOCA-salt hypertensive rats
-
Nam SC, Kang S, Kim W, Lee J
- KMID: 1580640
- Korean J Physiol Pharmacol.
- 2000 Feb;4(1):55-61.
The present study was conducted to investigate the possible role of the sympathetic nervous system in two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension. 2K1C and DOCA-salt hypertension were made in Sprague-Dawley... -
- CITED
-
- Close
- SHARE
-
- Close
- Altered Vascular Expression of Nitric Oxide Synthase Isozymes in Hypertension
-
Kim IK, Kang DG, Lee JE, Oh BS
- KMID: 1915496
- Korean J Thorac Cardiovasc Surg.
- 1999 Feb;32(2):138-143.
BACKGROUND: The endothelium-dependent vasorelaxation has been largely accounted for by the release of nitric oxide (NO). Three distinct isoforms of NO synthases (NOS) have been characterized, i.e., brain(bNOS), inducible (iNOS),... -
- CITED
-
- Close
- SHARE
-
- Close
- Pathophysiological Implications of Sodium Transporters and Water Channels in the Kidney
-
Kim SW, Ma SK, Bae EH, Park JW, Lee JU
- KMID: 2253199
- Korean J Nephrol.
- 2009 Jan;28(1):1-9.
Renal sodium and water reabsorption occurs through epithelial sodium transporters and aquaporin (AQP) water channels in various segments of tubules. We have demonstrated altered regulation of these transporters and channels... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Tamoxifen in Deoxycorticosterone Acetate-salt Hypertensive Nephropahty
-
Choi JS, Kim IJ, Kim CS, Bae EH, Ma SK, Lee JU, Kim SW
- KMID: 1838116
- J Korean Soc Hypertens.
- 2013 Dec;19(4):123-131.
- doi: 10.5646/jksh.2013.19.4.123
BACKGROUND: The present study was designed to evaluate the possible renoprotective effects of tamoxifen in deoxycorticosterone acetate (DOCA)-salt hypertensive (DSH) rats and its role in inflammation and fibrosis in the... -
- CITED
-
- Close
- SHARE
-
- Close
- Altered Regulation of 11beta-hydroxysteroid Dehydrogenase II in the Kidney of Rats with Experimental Hypertension
-
Kang SS, Kim SW, Lee JU
- KMID: 2052290
- Electrolyte Blood Press.
- 2007 Dec;5(2):89-94.
- doi: 10.5049/EBP.2007.5.2.89
The present study was aimed at investigating the role of type II 11beta-hydroxysteroid dehydrogenase (IIbeta- HSD II) in the development of hypertension. Two-kidney, one-clip (2K1C), deoxycorticosterone acetate (DOCA)/salt, or NG-nitro-L-arginine... -
- CITED
-
- Close
- SHARE
-
- Close
- Modulation of Baroreflexes in Hypertensive Rats
-
Choi S, Kim JH, Sun JM, Whi HW, Choi SJ, Jun JY, Yoon PJ, Chung JH, Kim HI, Yeum CH
- KMID: 2307162
- Korean J Nephrol.
- 2009 Nov;28(6):545-551.
PURPOSE: Baroreceptor reflex regulation has been shown to reset towards a higher blood pressure level. This study was designed to assess alterations of chronotropic baroreflexes in two-kidney, one clip (2K1C)... -
- CITED
-
- Close
- SHARE
-
- Close
- Oxidatvive Stress in Rat Model of Preeclampsia and Clinical Correlates
-
Chang YJ, Lee WK, Kim HG
- KMID: 2285336
- Korean J Physiol Pharmacol.
- 2007 Jun;11(3):129-133.
There are growing evidences suggesting a pivotal role of oxidative stress in the pathophysiology of preeclampsia. We investigated oxidative stress in the rat model of preeclampsia, and in clinical cases.... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of Prostaglandins on the Renin-Angiotensin System in Normotensive and Hypertensive Rats
-
Yoon PJ, Jung M, Kim JS, Jun JY, Yeum CH
- KMID: 2228945
- Korean Circ J.
- 1996 Apr;26(2):553-560.
- doi: 10.4070/kcj.1996.26.2.553
BACKGROUND: Prostaglandin system is known to participate in manifestation of the renin-angiotensin system. However, role of prostaglandins on the renin-angiotensin system in development of hypertension is not well established. This... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of Male Pseudohermaphroditism due to 17alpha-Hydroxylase Deficiency
-
Park KA, Chung YK, Lee JR, Choi YM, Lee GH, Kim HS, Jee BC, Ku SY, Suh CS, Kim SH, Kim JG, Moon SY, Kim SY
- KMID: 1830752
- Korean J Fertil Steril.
- 2006 Jun;33(2):133-138.
Female phenotype of a 46,XY male may originates from male pseudohermaphroditism due to 17alpha-hydroxylase deficiency. Lack of cortisol increases adrenocorticotropic hormone (ACTH) and mineralocorticoid production, leading to low renin hypertention... -
- CITED
-
- Close
- SHARE
-
- Close
