- Dissecting the molecular mechanism of nuclear receptor action: transcription coactivators and corepressors
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Lee JW, Cheong JH, Lee YC, Na SY, lee SK
- KMID: 1109302
- Exp Mol Med.
- 2000 Jun;32(2):53-60.
No abstract available. -
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- Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation
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Choi KY, Yoo M, Han JH
- KMID: 2070274
- Exp Mol Med.
- 2015 Apr;47(4):e155.
- doi: 10.1038/emm.2014.129
The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know... -
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- Different protein-binding patterns in the P3 promoter region of the human insulin-like growth factor II gene in the human liver cirrhosis and hepatocellular carcinoma tissues
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Seo JH, Kim KW, Park BC
- KMID: 1064965
- J Korean Med Sci.
- 1998 Apr;13(2):171-178.
- doi: 10.3346/jkms.1998.13.2.171
The P3 promoter of the human insulin-like growth factor II (IGF-II) is the major IGF-II promoter in fetal liver (FL) and hepatocellular carcinoma (HCC). However, little information is available... -
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- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Ciechanover A, Kwon YT
- KMID: 2155412
- Exp Mol Med.
- 2015 Mar;47(3):e147.
- doi: 10.1038/emm.2014.117
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the... -
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- Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse intestinal epithelial cells
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Lee YS, Lee EK, Han IO, Park SH
- KMID: 1103587
- Exp Mol Med.
- 2008 Feb;40(1):43-51.
- doi: 10.3858/emm.2008.40.1.43
The inhibitory Smad6 and Smad7 are responsible for cross-talk between TGF-beta/bone morphogenic protein (BMP) signaling and other cellular signaling pathways, as well as negative feedback on their own signaling functions.... -
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- Protein kinase A mediates microglial activation induced by plasminogen and gangliosides
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Min KJ, Yang MS, Jou I, Joe EH
- KMID: 1123767
- Exp Mol Med.
- 2004 Oct;36(5):461-467.
In the injured brain, microglia is known to be activated and produce proinflammatory mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). We investigated... -
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- Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability
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Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC
- KMID: 1785795
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S91-S97.
- doi: 10.3346/jkms.2007.22.S.S91
To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history... -
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- Metastatic Common Bile Duct Cancer from Pulmonary Adenocarcinoma Presenting as Obstructive Jaundice
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Cha IH, Kim JN, Kim YS, Ryu SH, Moon JS, Lee HK
- KMID: 1775788
- Korean J Gastroenterol.
- 2013 Jan;61(1):50-53.
- doi: 10.4166/kjg.2013.61.1.50
We report an extremely rare case of metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice. The patient was a 76-year-old male, who presented with generalized weakness... -
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- Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells
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Choi JH, Kim JS, Kim YC, Kim YS, Chung NH, Cho MH
- KMID: 1094683
- J Vet Sci.
- 2004 Mar;5(1):11-18.
Accurate estimation of the exposure-response relationship between ambient urban particulate matters (PM) and public health is important for regulatory perspective of ambient urban particulate matters (PM). Ambient PM contains various... -
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- Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells
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Park HY, Jeon YK, Shin HJ, Kim IJ, Kang HC, Jeong SJ, Chung DH, Lee CW
- KMID: 1094660
- Exp Mol Med.
- 2007 Apr;39(2):195-204.
The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation of chromosome-spindle attachment to mitotic-checkpoint signaling. Thus, disruption of BubR1 activity results in a loss of... -
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- The DPE, a core promoter element for transcription by RNA polymerase II
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Kadonaga J
- KMID: 931875
- Exp Mol Med.
- 2002 Sep;34(4):259-264.
The core promoter is an important yet often overlooked component in the regulation of transcription by RNA polymerase II. In fact, the core promoter is the ultimate target of... -
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- Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
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Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I
- KMID: 1115265
- Exp Mol Med.
- 2010 Dec;42(12):811-822.
- doi: 10.3858/emm.2010.42.12.084
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases,... -
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- Transforming variant of Met receptor confers serum independence and anti-apoptotic property and could be involved in the mouse thymic lymphomagenesis
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Baek CM, Jeon SH, Jang JJ, Lee BS, Lee JH
- KMID: 1094072
- Exp Mol Med.
- 2004 Aug;36(4):283-291.
Met tyrosine kinase receptor, the receptor of hepatocyte growth factor/scatter factor (HGF/SF), is present in mouse tissues as two major isoforms differing by a 47-aminoacid segment in the juxtamembrane domain... -
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- Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells
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Chung HK, Lee IK, Kang HK, Suh JM, Kim H, Park KC, Kim DW, Kim YK, Ro HK, Shong MH
- KMID: 1121099
- Exp Mol Med.
- 2002 Dec;34(6):451-461.
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, are widely used for primary and secondary prevention of coronary artery atherosclerosis. Pathogenesis of atherosclerosis is multistep processes where... -
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- Factors Influencing the Response to High Dose Methotrexate-based Vincristine and Procarbazine Combination Chemotherapy for Primary Central Nervous System Lymphoma
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Sung KH, Lee EH, Kim YZ
- KMID: 1777887
- J Korean Med Sci.
- 2011 Apr;26(4):551-560.
- doi: 10.3346/jkms.2011.26.4.551
The authors investigated objective response rate to high dose methotrexate (HDMTX)-based combination chemotherapy in primary central nervous system lymphoma (PCNSL), and sought to identify factors that influence response to HDMTX-based... -
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