- DNA Methylation Changes Following 5-azacitidine Treatment in Patients with Myelodysplastic Syndrome
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Tran HT, Kim HN, Lee IK, Kim YK, Ahn JS, Yang DH, Lee JJ, Kim HJ
- KMID: 1782108
- J Korean Med Sci.
- 2011 Feb;26(2):207-213.
- doi: 10.3346/jkms.2011.26.2.207
DNA methyltransferase inhibitor, 5-azacitidine (AC) is effective in myelodysplastic syndromes (MDS) and can induce re-expression in cancer. We analyzed the methylation of 25 tumor suppressor genes in AC-treated MDS. Hypermethylation... -
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- Pharmacological Unmasking Microarray Approach-Based Discovery of Novel DNA Methylation Markers for Hepatocellular Carcinoma
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Jung N, Won JK, Kim BH, Suh KS, Jang JJ, Kang GH
- KMID: 1421610
- J Korean Med Sci.
- 2012 Jun;27(6):594-604.
- doi: 10.3346/jkms.2012.27.6.594
DNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes. To find novel DNA methylation markers in hepatocellular... -
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