- Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells
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Jung HJ, Ka WH, Hwang JN, Seo YR
- KMID: 1611497
- Korean J Physiol Pharmacol.
- 2004 Dec;8(6):345-349.
Heat shock (43oC for 60 minutes) is sufficient to induce apoptosis in a wide number of cell lines. In this study, we asked whether DNA strand breaks are responsible for... -
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- DNA damage to human genetic disorders with neurodevelopmental defects
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Lee Y, Choi I, Kim J, Kim K
- KMID: 2327696
- J Genet Med.
- 2016 Jun;13(1):1-13.
- doi: 10.5734/JGM.2016.13.1.1
Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich... -
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- The Expressions of p53, gamma-H(2)AX and Ku70/Ku80 That was Caused by Hydronephrosis in the Kidney of Rats
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Moon C, Moon HY, Kim CS
- KMID: 2061301
- Korean J Urol.
- 2007 Sep;48(9):976-983.
- doi: 10.4111/kju.2007.48.9.976
PURPOSE: There are little research about the factors of DNA damage and repair that might cause renal parenchymal damage under the condition of hydronephrosis. In this study, we studied the... -
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- Back to the Ends: Chromosomal DNA
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Lee MH, Suh D
- KMID: 2322080
- J Korean Soc Pediatr Nephrol.
- 2008 Apr;12(1):1-10.
Nucleic scids transfer the genetic information for serving a central biological purpose. The nucleic acids are polymers of nucleotides and they are mainly ribonucleic acid(RNA) and deoxyribonucleic acid(DNA). The nucleotides... -
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- DNA Double Strand Breaks in Gastric Epithelium with Helicobacter pylori Infection
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Chang YJ, Byun SW, Kim HK, Cho YS, Kim SS, Kim JI, Kim JK, Jung ES
- KMID: 1387335
- Korean J Gastroenterol.
- 2012 Aug;60(2):79-85.
- doi: 10.4166/kjg.2012.60.2.79
BACKGROUND/AIMS: DNA double strand breaks (DSB) is one of the critical types of DNA damage. If unrepaired, DSB is accumulated in the nucleus of cells, the cells become apoptotic or... -
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- Apoptosis of Murine Macrophage-like Cells Infected with Orientia tsutsugamushi
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Choi NJ, Kim MK, Park HJ, Lim BU, Kang JS
- KMID: 2146930
- J Korean Soc Microbiol.
- 1998 Aug;33(4):399-406.
A large number of bacterial pathogens have been identified as mediators of apoptosis in vitro and the induction of apoptosis might be an important step in the pathogenesis of these... -
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- Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase
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Kim CH, Cuong DV, Kim JS, Kim N, Kim E, Han J
- KMID: 1607348
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):9-14.
Recent studies indicated that cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs by enhanced DNA repair of the lesions. Therefore, it is expected to increase the killing... -
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- Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines
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Avila-Arroyo S, Nunez GS, Garcia-Fernandez LF, Galmarini
- KMID: 2176281
- J Breast Cancer.
- 2015 Dec;18(4):329-338.
- doi: 10.4048/jbc.2015.18.4.329
PURPOSE: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP)... -
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- PREFACE: How Dangerous Are X-ray Studies That We Undertake Every Day?
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Kim DI
- KMID: 2363373
- J Korean Med Sci.
- 2016 Feb;31(Suppl 1):S2-S3.
- doi: 10.3346/jkms.2016.31.S1.S2
No abstract available. -
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- Mechanism of Cell Death in Pancreatitis Induced by Pancreaticobiliary Duct Obstruction in the Rat
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Park KN, Rhee JC, Lee KT, Kong G
- KMID: 2240559
- Korean J Gastroenterol.
- 1998 Aug;32(2):218-229.
BACKGROUND AND AIMS: Mechanism of cell death in human and experimental pancreatitis remain poorly understood. Thus, this study was designed to determine the mechanism of cell death in the model... -
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- Effect of electromagnetic field exposure on the reproductive system
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Gye MC, Park CJ
- KMID: 2167513
- Clin Exp Reprod Med.
- 2012 Mar;39(1):1-9.
- doi: 10.5653/cerm.2012.39.1.1
The safety of human exposure to an ever-increasing number and diversity of electromagnetic field (EMF) sources both at work and at home has become a public health issue. To date,... -
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- Pyruvate Protects Giardia Trophozoites from Cysteine-Ascorbate Deprived Medium Induced Cytotoxicity
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Raj D, Chowdhury , Sarkar R, Saito-Nakano Y, Okamoto K, Dutta S, Nozaki T, Ganguly S
- KMID: 2408518
- Korean J Parasitol.
- 2018 Feb;56(1):1-9.
- doi: 10.3347/kjp.2018.56.1.1
Giardia lamblia, an anaerobic, amitochondriate protozoan parasite causes parasitic infection giardiasis in children and young adults. It produces pyruvate, a major metabolic product for its fermentative metabolism. The current study... -
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- Prognostic Value of Apoptosis in Breast Cancer
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Song HS, Yoon DS, Park CH, Nam ES, Sin HS
- KMID: 2206405
- J Korean Surg Soc.
- 1998 Oct;55(4):492-497.
The aim of this study was to determine if the apoptotic degree could predict the prognosis for breast cancer in mastectomy specimens and to establish if any association existed between... -
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- Inhibitory Effect of Melatonin on Kainic Acid-Induced Hippocampal Neuronal Injury
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Chung SY, Han SH, Hu JK, Kim YH, Lee IG, Whang KT
- KMID: 2007315
- J Korean Child Neurol Soc.
- 2001 Oct;9(2):278-288.
PURPOSE: It has been suggested that the pineal hormone melatonin(MEL) protects neurons in vitro from excitotoxicity mediated by kainate-sensitive glutamate receptors and from oxidative stress-induced DNA damage and apoptosis. The... -
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- Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress
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Oh MC, Piao MJ, Fernando P, Han X, Hewage SR, Park JE, Ko MS, Jung U, Kim IG, Hyun JW
- KMID: 2374616
- Biomol Ther.
- 2016 Nov;24(6):616-622.
- doi: 10.4062/biomolther.2016.022
Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced... -
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- The Effects of Mild Hypothermia on the Expression of the Apoptosis-related Proteins following Transient Global Ischemia in Gerbil Hippocampus
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Kim YM, Park KN, Choi SP, Hong TY, Kim SK
- KMID: 1931787
- Korean J Crit Care Med.
- 2007 Jun;22(1):30-41.
BACKGROUND: The neuroprotective mechanisms of hypothermia remain unclear. Recently, attenuation of apoptosis by hypothermia has been suggested as one of the responsible mechanisms. The aim of this study is to... -
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- Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma
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Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES
- KMID: 1775922
- Korean J Gastroenterol.
- 2010 Jan;55(1):19-25.
- doi: 10.4166/kjg.2010.55.1.19
BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such... -
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- Clinicopathological values of NBS1 and DNA damage response genes in epithelial ovarian cancers
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Lee YK, Park NH, Lee H
- KMID: 2359882
- Exp Mol Med.
- 2015 Nov;47(11):e195.
- doi: 10.1038/emm.2015.85
Epithelial ovarian cancers (EOCs) are highly lethal gynecological malignancies with a high recurrence rate. Therefore, developing prognostic markers for recurrence after chemotherapy is crucial for the treatment of ovarian cancers.... -
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- The Expression of Apoptosis in Lupus Nephritis
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Yun SC, Cho JT, Lee JG, Kim YJ
- KMID: 2251408
- Korean J Med.
- 1998 Sep;55(3):375-382.
BACKGROUND: A few researches on apoptosis in proliferative glomerulonephritis including lupus nephritis, have been reported on the basis of animal experimental models and human renal biopsy tissues. Systemic lupus erythematosus... -
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- Apple pectin, a dietary fiber, ameliorates myocardial injury by inhibiting apoptosis in a rat model of ischemia/reperfusion
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Lim SH, Kim MY, Lee J
- KMID: 2313755
- Nutr Res Pract.
- 2014 Aug;8(4):391-397.
BACKGROUND/OBJECTIVE: Myocardial cell death due to occlusion of the coronary arteries leads to myocardial infarction, a subset of coronary heart disease (CHD). Dietary fiber is known to be associated with... -
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