- Pharmacogenetics and Depression: A Critical Perspective
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Corponi F, Fabbri C, Serretti A
- KMID: 2459684
- Psychiatry Investig.
- 2019 Sep;16(9):645-653.
- doi: 10.30773/pi.2019.06.16
Depression leads the higher personal and socio-economical burden within psychiatric disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal response still poses a major challenge and is... -
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- Voriconazole-refractory invasive aspergillosis
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Park SY, Yoon JA, Kim SH
- KMID: 2411481
- Korean J Intern Med.
- 2017 Sep;32(5):805-812.
- doi: 10.3904/kjim.2017.109
Invasive aspergillosis (IA) is one of the most common life-threatening complications in immunocompromised patients. Voriconazole is currently the drug of choice for IA treatment. However, some patients with IA suffer... -
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- Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers
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Park S, Hyun YJ, Kim YR, Lee JH, Ryu S, Kim JM, Oh WY, Na HS, Lee JG, Seo DW, Hwang IY, Park Z, Jang IJ, Oh J, Choi SE
- KMID: 2375071
- J Korean Med Sci.
- 2017 May;32(5):729-736.
- doi: 10.3346/jkms.2017.32.5.729
The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled... -
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- Underlying Mechanisms and Management of Refractory Gastroesophageal Reflux Disease
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Lee KJ
- KMID: 2373317
- Korean J Gastroenterol.
- 2015 Aug;66(2):70-74.
- doi: 10.4166/kjg.2015.66.2.70
The prevalence of gastroesophageal reflux disease (GERD) in South Korea has increased over the past 10 years. Patients with erosive reflux disease (ERD) shows better response to proton pump inhibitors... -
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- Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines Part 2
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Kim S, Yun YM, Kim IS, Song SH, Woo HI, Lee KA, Lee W, Cho HJ, Ji M, Chae HJ, Lee SY, Chun S
- KMID: 2353421
- Lab Med Online.
- 2016 Oct;6(4):193-213.
- doi: 10.3343/lmo.2016.6.4.193
Pharmacogenetics is a rapidly evolving field and the number of pharmacogenetic tests for clinical use is steadily increasing. However, incorrect or inadequate implementation of pharmacogenetic tests in clinical practice may... -
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- Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping
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Han SW, Kim YJ, Ahn SH, Seo WK, Yu S, Oh SH, Nam HS, Choi HY, Yoon SS, Kim SH, Lee JY, Lee JH, Hwang YH, Lee KO, Jung YH, Lee J, Sohn SI, Kim YN, Lee KA, Bushnell C, Lee KY
- KMID: 2408402
- J Stroke.
- 2017 Sep;19(3):356-364.
- doi: 10.5853/jos.2017.01249
BACKGROUND AND PURPOSE: To compare the efficacy and safety of antiplatelet agents for the secondary prevention of ischemic stroke based on cytochrome P450 2C19 (CYP2C19) polymorphisms. METHODS: This study was a... -
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- Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines
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Kim S, Yun YM, Chae HJ, Cho HJ, Ji M, Kim IS, Wee KA, Lee W, Song SH, Woo HI, Lee SY, Chun S
- KMID: 2373642
- Ann Lab Med.
- 2017 Mar;37(2):180-193.
- doi: 10.3343/alm.2017.37.2.180
Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended... -
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- Correlation Between the CYP2C19 Phenotype Status and the Results of Three Different Platelet Function Tests in Cardiovascular Disease Patients Receiving Antiplatelet Therapy: An Emphasis on Newly Introduced Platelet Function Analyzer-200 P2Y Test
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Li S, Choi JL, Guo LZ, Goh RY, Kim BR, Woo KS, Kim MH, Han JY
- KMID: 2373496
- Ann Lab Med.
- 2016 Jan;36(1):42-48.
- doi: 10.3343/alm.2016.36.1.42
BACKGROUND: An association has been reported between CYP2C19 polymorphism and the altered antiplatelet activity of clopidogrel. We investigated this association using the newly introduced platelet function analyzer (PFA)-200 (INNOVANCE PFA-200... -
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- Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis
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Chang YW, Ko WJ, Oh CH, Park YM, Oh SJ, Moon JR, Cho JH, Kim JW, Jang JY
- KMID: 2457025
- Korean J Intern Med.
- 2019 Sep;34(5):1022-1029.
- doi: 10.3904/kjim.2018.054
BACKGROUND/AIMS: The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea. We evaluated whether clinical parameters,... -
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- Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea
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Choi YJ, Kim N, Jang IJ, Cho JY, Nam RH, Park JH, Jo HJ, Yoon H, Shin CM, Park YS, Lee DH, Jung HC
- KMID: 2412230
- Gut Liver.
- 2017 Jul;11(4):504-511.
- doi: 10.5009/gnl16352
BACKGROUND/AIMS: Concerns that proton pump inhibitors (PPIs) diminish the efficacy of clopidogrel could hamper the appropriate prescription of PPIs. We evaluated the influence of pantoprazole on the antiplatelet effect of... -
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- Rifabutin-based Fourth and Fifth-line Rescue Therapy in Patients with for Helicobacter pylori Eradication Failure
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Sung J, Kim N, Park YH, Hwang YJ, Kwon S, Na G, Choi JY, Kang JB, Kim HR, Kim JW, Lee DH
- KMID: 2383420
- Korean J Gastroenterol.
- 2017 Feb;69(2):109-118.
- doi: 10.4166/kjg.2017.69.2.109
BACKGROUND/AIMS: Optimized regimen has not yet been established for failures of multiple Helicobacter pylori (H. pylori) eradication. Hence, we aimed to evaluate the efficacy of rifabutin-based rescue therapy, at least... -
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