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Partial Purification and Characterization of a Cysteine Protease Inhibitor from the Plerocercoid of Spirometra erinacei

Chung YB, Yang HJ

Helminthic cysteine proteases are well known to play critical roles in tissue invasion, nutrient uptake, and immune evasion of the parasites. In the same manner, the sparganum, the plerocercoid of...
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Partial Purification and Properties of a Cysteine Protease from Citrus Red Mite Panonychus citri

Hong SC, Her KH, Kim HU, Lee J, Lee SP, Chung YB

Several studies have reported that the citrus red mites Panonychus citri were an important allergen of citrus-cultivating farmers in Jeju Island. The aim of the present study was to purify...
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Isolation and characterization of a 40 kDa cysteine protease from Gymnophalloides seoi adult worms

Choi MH, Park WJ, Park YK, Chai JY, Lee SH

A 40 kDa cysteine protease was purified from the crude extract of adult worms of Gymnophalloides seoi by two consecutive steps: Sephacryl S-200 HR and DEAE-Sephacel chromatography. Enzyme activities were...
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Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes

Kim JY, Yang HJ, Kim KS, Chung YB

A 29 kDa cysteine protease of Taenia solium metacestodes was purified by Mono Q anion-exchanger and Superose 6 HR gel filtration chromatography. The enzyme was effectively inhibited by cysteine protease...
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Characterization of HC58cDNA, a putative cysteine protease from the parasite Haemonchus contortus

Muleke CI, Ruofeng Y, Lixin X, Yanming S, Xiangrui L

Because of the complexity of the cathepsin B-like (CBL) family, an information on the biological and biochemical characteristics of individual CBL genes is lacking. In this study, we investigated the...
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D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells

Kwon KB, Park EK, Ryu DG, Park BH

  • KMID: 1093595
  • Exp Mol Med.
  • 2002 Mar;34(1):32-37.
Daunorubicin, an anti-cancer drug, is known to induce apoptosis in HL-60 cells in a dose-dependent manner through the activation of caspase-3 (CPP32). Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation...
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Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells

Gong X, Wang M, Wu Z, Tashiro SI, Onodera S, Ikejima T

  • KMID: 1103322
  • Exp Mol Med.
  • 2004 Dec;36(6):551-556.
Pseudolaric acid B was isolated from Pseudolarix kaempferi Gordon (Pinaceae) and was evaluated for the anti-cancer effect in HeLa cells. We observed that pseudolaric acid B inhibited cell proliferation and...
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Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL

Woo KM, Kim HM, Ko JS

  • KMID: 755205
  • Exp Mol Med.
  • 2002 Nov;34(5):340-346.
Macrophage colony-stimulating factor (M-CSF) is known as one of the factors essential for osteoclast development. In the present study, we examined effects of M-CSF on the apoptotic pathway of osteoclast...
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Human Telomerase Reverse Transcriptase (hTERT): A Target Molecule for the Treatment of Cisplatin-resistant Tumors

Park YP, Kim KD, Kang SH, Yoon DY, Park JW, Kim JW, Lee HG

BACKGROUND: Human telomerase reverse transcriptase (hTERT) is a catalytic enzyme that is required for telomerase activity (TA) and cancer progression. Telomerase inhibition or inactivation increases cellular sensitivity to UV irradiation,...
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