- Cholesterol Depletion in Cell Membranes of Human Airway Epithelial Cells Suppresses MUC5AC Gene Expression
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Song KJ, Kim NH, Lee GB, Kim JH, Kwon JH, Kim KS
- KMID: 1727882
- Yonsei Med J.
- 2013 May;54(3):679-685.
- doi: 10.3349/ymj.2013.54.3.679
PURPOSE: If cholesterol in the cell membrane is depleted by treating cells with methyl-beta-cyclodextrin (MbetaCD), the activities of transmembrane receptors are altered in a cell-specific and/or receptor-specific manner. The proinflammatory... -
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- Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts
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Kim S, Oh JH, Lee Y, Lee J, Cho KH, Chung JH
- KMID: 946668
- Exp Mol Med.
- 2010 Jan;42(1):38-46.
- doi: 10.3858/emm.2010.42.1.004
Cholesterol is one of major components of cell membrane and plays a role in vesicular trafficking and cellular signaling. We investigated the effects of cholesterol on matrix metalloproteinase-2 (MMP-2) activation... -
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- GD3 Accumulation in Cell Surface Lipid Rafts Prior to Mitochondrial Targeting Contributes to Amyloid-beta-induced Apoptosis
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Kim JK, Kim SH, Cho HY, Shin HS, Sung HR, Jung JR, Quan ML, Jiang DH, Bae HR
- KMID: 2157855
- J Korean Med Sci.
- 2010 Oct;25(10):1492-1498.
- doi: 10.3346/jkms.2010.25.10.1492
Neuronal apoptosis induced by amyloid beta-peptide (A beta) plays an important role in the pathophysiology of Alzheimer's disease (AD). However, the molecular mechanism underlying A beta-induced apoptosis remains undetermined. The... -
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