- Evolution of Phosphodiesterase-5 Inhibitors
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Moon DG
- KMID: 2405139
- World J Mens Health.
- 2015 Dec;33(3):123-124.
- doi: 10.5534/wjmh.2015.33.3.123
No abstract available. -
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- Past, Present and Future of PDE5 Inhibitor
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Kim JJ, Moon DG
- KMID: 2226569
- Korean J Androl.
- 2008 Jun;26(2):49-60.
The phosphodiesterase type-5 inhibitors (PDE5-Is) sildenafil, vardenafil and tadalafil are widely used as first-line therapy for erectile dysfunction (ED). Since the approval of sildenafil in 1998, more than 40 million... -
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- Corporeal Fibrosis and Erectile Dysfunction as Sequelae of Unrepaired Penile Blunt Trauma
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Jo DJ, Ryu DS, Yang SJ
- KMID: 2298761
- Korean J Androl.
- 2010 Dec;28(3):226-228.
Penile fracture is an injury caused by the rupture of the tunica albuginea. We report an uncommon case of penile fracture with corporeal fibrosis and erectile dysfunction in a 45-year-old... -
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- Therapeutic Angiogenesis as a Potential Future Treatment Strategy for Erectile Dysfunction
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Ryu JK, Suh JK
- KMID: 2320881
- World J Mens Health.
- 2012 Aug;30(2):93-98.
The cavernous endothelium plays a crucial role in regulating the tone of the underlying smooth muscle and physiologic penile erection. Recently, the link between erectile dysfunction (ED) and cardiovascular disease... -
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- Evaluation for the Effects of Intrathecal Sildenafil on the Formalin- and Thermal-induced Nociception of Rats
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Yoon MH, Bae HB, Shin DJ, Kim CM, Jeong ST, Kim SJ, Choi JI
- KMID: 2278011
- Korean J Pain.
- 2006 Jun;19(1):17-21.
- doi: 10.3344/kjp.2006.19.1.17
BACKGROUND: Cyclic guanosine monophosphate (cGMP) plays an important role in the modulation of nociception. Although local sildenafil produces antinociception, by increasing cGMP through the inhibition of phosphodiesterase 5, the effect... -
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- The Analysis of Clinical Efficacy of Phosphodiesterase 5 Inhibitors for Erectile Dysfunction using SS-Penogram
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Choi KH, Soh BH, Oh CY, Kim JH, Choi HK
- KMID: 2298730
- Korean J Androl.
- 2009 Dec;27(3):194-200.
PURPOSE: As the first-line pharmacotherapy for erectile dysfunction (ED), phosphodiesterase type 5 (PDE5) inhibitors are widely used and their clinical efficacy is well established. But up to now, most of... -
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- The Influence of Treatment-emergent Adverse Reactions on Selecting Phosphodiesterase Type 5 Inhibitors
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Yang CS, Kim SC
- KMID: 2294174
- Korean J Urol.
- 2006 Mar;47(3):272-278.
- doi: 10.4111/kju.2006.47.3.272
PURPOSE: This study was conducted to determine how treatment-emergent adverse reactions (ARs) of each of the phosphodiesterase type 5 inhibitors (PDE5Is) influenced the patient when selecting a drug. MATERIALS AND METHODS:... -
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- A current perspective on post-micturition dribble in males
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Yang DY, Lee WK
- KMID: 2444267
- Investig Clin Urol.
- 2019 May;60(3):142-147.
- doi: 10.4111/icu.2019.60.3.142
Post-micturition dribble (PMD) is the involuntary loss of urine immediately after urination. It is classified as a post-micturition symptom and is more common in males. Traditionally, PMD has been considered... -
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- Use of Inhaled Iloprost in an Infant With Bronchopulmonary Dysplasia and Pulmonary Artery Hypertension
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Hwang SK, O YC, Kim NS, Park HK, Yum MK
- KMID: 2225686
- Korean Circ J.
- 2009 Aug;39(8):343-345.
- doi: 10.4070/kcj.2009.39.8.343
Pulmonary artery hypertension is a common cardiovascular complication in preterm infants with bronchopulmonary dysplasia which is associated with increased morbidity and mortality. Inhaled iloprost is used as a therapeutic option... -
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- A Case of Sexual Enhancer Induced Fixed Drug Eruption
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Lee SK, Kim DJ, Suh JH, Kim MS, Lee UH
- KMID: 2436688
- Korean J Dermatol.
- 2018 May;56(4):269-272.
Fixed drug eruption is a commonly reported mucocutaneous drug eruption. A 61-year-old male presented to our clinic with a complaint of an itchy round erythematous patch on the left hand... -
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- The Role of Opioid Receptor on the Analgesic Action of Intrathecal Sildenafil in Rats
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Lee HG, Jeong CY, Yoon MH, Kim WM, Shin SH, Kim YO, Huang LJ, Cui JH
- KMID: 2278035
- Korean J Pain.
- 2007 Jun;20(1):21-25.
- doi: 10.3344/kjp.2007.20.1.21
BACKGROUND: Intrathecal sildenafil has produced antinociception by increasing the cGMP through inhibition of phosphodiesterase 5. Spinal opioid receptor has been reported to be involved in the modulation of nociceptive transmission.... -
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- Stem Cell Therapy for Erectile Dysfunction
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Song YS
- KMID: 2298716
- Korean J Androl.
- 2007 Dec;25(3):89-96.
Although the introduction of oral phosphodiesterase-5 inhibitors has revolutionized the treatment of erectile dysfunction, there is still a need for new effective therapies for patients who fail to respond or... -
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- GABAB Receptor Modulation on the Antinociception of Intrathecal Sildenafil in the Rat Formalin Test
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Kim WM, Yoon MH, Lee HG, Han YG, Kim YO, Huang LJ, Cui JH
- KMID: 2278049
- Korean J Pain.
- 2007 Dec;20(2):106-110.
- doi: 10.3344/kjp.2007.20.2.106
BACKGROUND: A phosphodiesterase 5 inhibitor, sildenafil, has been effective against nociception. Several lines of evidence have demonstrated the role of the GABAergic pathway in the modulation of nociception. The impact... -
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- A Case of Acute Pulmonary Thromboembolism after Taking Tadalafil
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Lee J, Kwon JH, Lee CH, Lee SM, Yim JJ, Yoo CG, Kim YW, Han SK, Park YS
- KMID: 2320198
- Tuberc Respir Dis.
- 2012 Oct;73(4):231-233.
Tadalafil is a phosphodiesterase-5 inhibitor (PDE5I), which is widely used to treat erectile dysfunction. Although PDE5Is have excellent safety profiles, and most of the side effects are mild, rare serious... -
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- The Comparative Effects of PDE5 Inhibitors (Zaprinast, Sildenafil and Vardenafil) according to the Route of Administration in the Rabbit Model
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Moon I, Choi S
- KMID: 2294035
- Korean J Urol.
- 2005 Aug;46(8):849-853.
Purpose: Intracavernosal (IC) PDE5 (phosphodiesterase type 5) inhibitors, at tissue levels approaching millimolar concentrations, have been reported to cause penile erection in the absence of sexual stimulation. The objectives of... -
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- Expression Changes of the Phosphodiesterase 5 isoform in the Penis of Type 2 Diabetic Rat
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Ko K, Kim HJ, Han YK, Shim JB, Kim SY, Kim H, Yang DY
- KMID: 2226561
- Korean J Androl.
- 2008 Sep;26(3):123-129.
PURPOSE: To investigate the tissue distribution of PDE5 isoforms in type 2 diabetic rat penile tissues. MATERIALS AND METHODS: We prepared ten male Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which develop... -
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- Effects of Phosphodiesterase 5 Inhibition with Sildenafil on Atrial Contractile and Secretory Function
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Quan HX, Kim SY, Jin XS, Park JK, Kim SZ, Cho KW
- KMID: 2285326
- Korean J Physiol Pharmacol.
- 2006 Jun;10(3):149-154.
Selective inhibition of phosphodiesterase (PDE) 5 opened a new therapeutic approach for cardiovascular disorders. Therefore, the effect of PDE5 inhibition on the cardiac function should thoroughly be defined. The purpose... -
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- 5 Year Follow-up Results of Endoscopic Primary Realignment in Urethral Injury
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Park CS, Park SW, Kim JM, Lee JZ
- KMID: 1997095
- Korean J Urol.
- 2007 Nov;48(11):1165-1170.
- doi: 10.4111/kju.2007.48.11.1165
PURPOSE: The standard management of posterior urethral injury is controversial with regard to immediate primary realignment versus delayed urethroplasty. We analyzed the long-term results of treatment for urethral injury with... -
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- The Refill Rate and Reasons for Abandonment of Phosphodiesterase5 Inhibitors in Erectile Dysfunction Patients
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Sung HH, Woo KJ, Jeong JY, Han DH, Lee SW
- KMID: 1885548
- Korean J Urol.
- 2007 Jun;48(6):646-651.
- doi: 10.4111/kju.2007.48.6.646
PURPOSE: The aim of this study was to determine the rate of abandonment of phosphodiesterase (PDE)5 inhibitor therapy in patients who had reported good treatment efficacy, and to assess the... -
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- The Early Experience of Various Treatment Modalities for Female Sexual Dysfunction
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Lim JH, Min KS, Choi SH
- KMID: 2293291
- Korean J Urol.
- 2003 Oct;44(10):986-992.
PURPOSE: The aim of this study was to evaluate various medical treatments for the improvement of sexual function in women with sexual dysfunction. MATERIALS AND METHODS: Forty two patients that complained... -
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