- Phosphodiesterase 4D Gene and Risk of Noncardiogenic Ischemic Stroke in a Korean Population
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Kim MK, Kim JT, Choi SM, Lee SH, Park MS, Cho KH
- KMID: 1779135
- J Korean Med Sci.
- 2009 Apr;24(2):307-310.
- doi: 10.3346/jkms.2009.24.2.307
Recently published studies from different populations provide apparently conflicting evidence on the association between the phosphodiesterase 4D (PDE4D) gene and ischemic stroke. The relationship between a representative PDE4D genotype and... -
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- Incidence of Adverse Effects and Discontinuation Rate between Patients Receiving 250 Micrograms and 500 Micrograms of Roflumilast: A Comparative Study
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Joo H, Han D, Lee JH, Rhee CK
- KMID: 2420563
- Tuberc Respir Dis.
- 2018 Oct;81(4):299-304.
- doi: 10.4046/trd.2018.0015
BACKGROUND: Roflumilast is the only approved oral phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease (COPD) in patients with chronic bronchitis and a history of frequent exacerbations.... -
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- Effect of a Dose-Escalation Regimen for Improving Adherence to Roflumilast in Patients with Chronic Obstructive Pulmonary Disease
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Hwang H, Shin JY, Park KR, Shin JO, Song KH, Park J, Park JW
- KMID: 2320700
- Tuberc Respir Dis.
- 2015 Oct;78(4):321-325.
- doi: 10.4046/trd.2015.78.4.321
BACKGROUND: The adverse effects of the phosphodiesterase-4 inhibitor roflumilast, appear to be more frequent in clinical practice than what was observed in chronic obstructive pulmonary disease (COPD) clinical trials. Thus,... -
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- The Modulation of IL-12 by Phosphodiesterase IV Inhibitor and Subsequent Changes of Th-1, Th-2 Cytokines in Human Endometrial Tissue
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Park WI, Kim EK, Ko DS, Hong SY, Na JY, Shin JH, Kim DW
- KMID: 2272121
- Korean J Obstet Gynecol.
- 2003 Aug;46(8):1500-1509.
OBJECTIVE: To assess the capability of phosphodiesterase type IV inhibitor (rolipram) to suppress IL-12 in human decidua and the subsequent changes of Th-2 cytokine (IL-10) and Th-1 cytokine (TNF-alpha). METHODS: Decidual... -
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- Comparisons of the Characteristics for Non-hospitalized, Hospitalized, and Rehospitalized Patients due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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Choi JY, Yun SY
- KMID: 2455724
- Korean J Adult Nurs.
- 2019 Aug;31(4):427-438.
- doi: 10.7475/kjan.2019.31.4.427
PURPOSE: This study compares the characteristics of patients with Chronic Obstructive Pulmonary Disease (COPD) according to hospitalization frequency due to Acute Exacerbation (AE) using a retrospective medical records review. METHODS: From... -
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- Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus
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Muñoz-Pérez VM, Fernández-MartÃnez E, Ponce-Monter H, Ortiz MI
- KMID: 2384457
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):429-437.
- doi: 10.4196/kjpp.2017.21.4.429
The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats... -
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