- Protein Kinase C-delta Mediates Nitric Oxide- induced Proliferation of Gastric Cancer Cells, MKN-2
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Kim HH, Park KJ, Kwak JY
- KMID: 2004571
- J Korean Surg Soc.
- 2003 Mar;64(3):194-200.
PURPOSE: The purpose of this study was to investigate the effect of exogenous nitric oxide (NO) on the proliferation of gastric carcinoma cells and the signaling pathways that regulate these... -
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- Effects of hydrogen peroxide on voltage-dependent K+ currents in human cardiac fibroblasts through protein kinase pathways
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Bae H, Lee D, Kim YW, Choi J, Lee HJ, Kim SW, Kim T, Noh YH, Ko JH, Bang H, Lim I
- KMID: 2285604
- Korean J Physiol Pharmacol.
- 2016 May;20(3):315-324.
- doi: 10.4196/kjpp.2016.20.3.315
Human cardiac fibroblasts (HCFs) have various voltage-dependent K+ channels (VDKCs) that can induce apoptosis. Hydrogen peroxide (H2O2) modulates VDKCs and induces oxidative stress, which is the main contributor to cardiac... -
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- Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons
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Jin Y, Kim J, Kwak J
- KMID: 1768016
- Korean J Physiol Pharmacol.
- 2012 Jun;16(3):211-217.
- doi: 10.4196/kjpp.2012.16.3.211
Recent studies have demonstrated that nitric oxide (NO) activates transient receptor potential vanilloid subtype 1 (TRPV1) via S-nitrosylation of the channel protein. NO also modulates various cellular functions via activation... -
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- Modulation of Ca2+ activated potassium channels by cGMP-dependent signal transduction mechanism in cerebral arterial smooth muscle cells of the rabbit
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Han J, Kim N, Lee K, Kim E
- KMID: 1581022
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):445-453.
The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2+-activated potassium channel (KCa channel) and is involved in the activation of KCa channel... -
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- Cinnamyl alcohol attenuates vasoconstriction by activation of K+ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase
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Kang YH, Yang IJ, Morgan KG, Shin HM
- KMID: 1402319
- Exp Mol Med.
- 2012 Dec;44(12):749-755.
Cinnamyl alcohol (CAL) is known as an antipyretic, and a recent study showed its vasodilatory activity without explaining the mechanism. Here we demonstrate the vasodilatory effect and the mechanism of... -
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- Nitric Oxide Prevents the IFN-gamma/LPS-induced Hepatocytic Cell Death in a Protein Kinase G-independent Manner
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Chung SY, Choi SJ, Kim SK, So HS, Jung BH, Song HS, Kim MS, Park JS, Chae KM, Lee JH, Che HJ, Kim HR, Chung HT, Park R
- KMID: 1807464
- Chonnam Med J.
- 2000 Jun;36(2):209-218.
Although it has been well known that the role of LPS on liver damage is mediated through TNF-alpha, the direct cytotoxic effect of LPS on IFN-gamma-primed hepatocytes has not yet... -
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- PPARgamma modulates vascular smooth muscle cell phenotype via a protein kinase G-dependent pathway and reduces neointimal hyperplasia after vascular injury
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Yang HM, Kim BK, Kim JY, Kwon YW, Jin S, Lee JE, Cho HJ, Lee HY, Kang HJ, Oh BH, Park YB, Kim HS
- KMID: 2154284
- Exp Mol Med.
- 2013 Nov;45(11):e65.
Vascular smooth muscle cells (VSMCs) undergo phenotypic changes in response to vascular injury such as angioplasty. Protein kinase G (PKG) has an important role in the process of VSMC phenotype... -
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- Dendroaspis natriuretic peptide regulates the cardiac L-type Ca2+ channel activity by the phosphorylation of alpha1c proteins
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Park SA, Kim TG, Han MK, Ha KC, Kim SZ, Kwak YG
- KMID: 1383798
- Exp Mol Med.
- 2012 Jun;44(6):363-368.
Dendroaspis natriuretic peptide (DNP), a new member of the natriuretic peptide family, is structurally similar to atrial, brain, and C-type natriuretic peptides. However, the effects of DNP on the cardiac... -
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- Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse Hippocampus
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Lee SH, Byun JS, Kong PJ, Lee HJ, Kim DK, Kim HS, Sohn JH, Lee JJ, Lim SY, Chun W, Kim SS
- KMID: 1457699
- Korean J Physiol Pharmacol.
- 2010 Feb;14(1):37-43.
- doi: 10.4196/kjpp.2010.14.1.37
The serine/threonine kinase Akt has been shown to play a role of multiple cellular signaling pathways and act as a transducer of many functions initiated by growth factor receptors that... -
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- Cardioprotective signaling cascade of A2 adenosine receptor agonist 5'-N-ethylcarboxaminidoadenosine against myocardial reperfusion injury
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Lee YC, Jang YH, Kim CJ, Kim JM
- KMID: 1782548
- Korean J Anesthesiol.
- 2008 Dec;55(6):716-722.
- doi: 10.4097/kjae.2008.55.6.716
BACKGROUND: This experiments investigated the signaling cascade responsible for anti-infarct effect by an A2 adenosine receptor (AR) agonist 5'-N-Ethylcarboxaminidoadenosine (NECA). METHODS: Langendorff perfused isolated rat hearts were subjected to 30 minutes... -
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- Action mechanisms of NANC neurotransmitters in smooth muscle of guinea pig ileum
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Lee YH, Kim JH, Kang BS
- KMID: 2285197
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):783-796.
The relaxation induced by stimulation of the inhibitory non-adrenergic, non-cholinergic (iNANC) nerve is mediated by the release of iNANC neurotransmitters such as nitric oxide (NO), vasoactive intestinal peptide (VIP) and adenosine triphosphate (ATP).... -
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- Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil
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Kim WM, Yoon MH, Cui JH
- KMID: 1110855
- J Vet Sci.
- 2010 Jun;11(2):103-106.
- doi: 10.4142/jvs.2010.11.2.103
Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium... -
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