- Multiple Regulation of Roundabout (Robo) Phosphorylation in a Heterologous Cell System
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Park HT
- KMID: 1611238
- Korean J Physiol Pharmacol.
- 2004 Apr;8(2):111-115.
Roundabout (Robo) is the transmembrane receptor for slit, the neuronal guidance molecule. In this study, the tyrosine phosphorylation of Robo was observed in Robo-transfected human embryonic kidney cells and developing... -
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- Signal Transduction Mechanisms Mediating Surfactant Phospholipid Secretion in Isolated Type II Cell
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Park SS
- KMID: 2317983
- Tuberc Respir Dis.
- 1996 Apr;43(2):123-127.
Secretion of surfactant phospholipid can be stimulated by a variety of agonists acting via at least three different signal transduction mechanisms. These include the adenylate cyclase system with activation of... -
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- Role of protein kinases on NF- kappaB activation and cell death in bovine cerebral endothelial cells
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Ahn YS, Kim CH, Kim JH
- KMID: 1917065
- Korean J Physiol Pharmacol.
- 1999 Feb;3(1):11-18.
Nuclear factor kappaB (NF- kappaB) activation is modulated by various protein kinases. Activation of NF- kappaB is known to be important in the regulation of cell viability. The present study investigated the effect... -
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- The Effects of Chronic Carbamazepine Administration on Protein Kinase A and Protein Kinase C Activities in Rat Brain
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Rheem DW, Kim L, Suh KY
- KMID: 2334572
- J Korean Soc Biol Psychiatry.
- 1998 Nov;5(2):227-234.
OBJECTIVE: Many evidences suggest that patients with bipolar disorder have functional abnormalities in their postreceptor signal transduction pathways, and mood stabilizing effect of lithium is exerted by modulating this dysfunctioning... -
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- Anesthetic experiences of myxoma removal surgery in two patients with Carney complex: A report of two cases
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Kang YM, Kim YH
- KMID: 1854070
- Korean J Anesthesiol.
- 2011 Dec;61(6):528-532.
- doi: 10.4097/kjae.2011.61.6.528
Carney complex is an autosomal dominant disorder that occurs due to a mutation in PRKAR1A, which encodes protein kinase A. The clinical features are multiple endocrine gland neoplasms, skin tumors,... -
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- PKA-Mediated Regulation of B/K Gene Transcription in PC12 Cells
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Choi MH, Kim HS, Choi SH, Kim MY, Jang YS, Jang YM, Lee JH, Jeong SW, Kim IK, Kwon OJ
- KMID: 2071616
- Korean J Physiol Pharmacol.
- 2005 Dec;9(6):333-339.
B/K protein is a novel protein containing double C2-like domains. We examined the specific signaling pathway that regulates the transcription of B/K in PC12 cells. When the cells were treated... -
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- The role of dependent pathway in eosinophil apoptosis
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Ki SY, Jeon KW, Lee MR, Uh ST, Kim YH, Park CS, Chung IY
- KMID: 2286031
- J Asthma Allergy Clin Immunol.
- 1999 Oct;19(5):667-684.
BACKGROUND: Interleukin-5 (IL-5), IL-3, and GM-CSF are known to prolong the survival of eosinophils, and IL-5 has the most potent effect on eosinophil survivaL It is also known that divergent signals induce... -
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- Carney Complex: Eleven Open Heart Operations in a Single Family
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Han SJ, Han W, Kang MW, Yu JH, Kang S, Na MH
- KMID: 2398382
- Korean J Thorac Cardiovasc Surg.
- 2017 Dec;50(6):471-473.
- doi: 10.5090/kjtcs.2017.50.6.471
Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat... -
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- Novel Mutation in PRKAR1A in Carney Complex
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Park KU, Kim HS, Lee SK, Jung WW, Park YK
- KMID: 2012066
- Korean J Pathol.
- 2012 Dec;46(6):595-600.
A case of Carney complex in a Korean patient is presented. The patient had the characteristics of Carney complex including skin lesions, positive family history, and multiple myxomas including a... -
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- Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated Protein Kinase Induced by Heme Oxygenase-1
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Kim JE, Sung JY, Woo CH, Kang YJ, Lee KY, Kim HS, Kwun WH, Choi HC
- KMID: 1448925
- Korean J Physiol Pharmacol.
- 2011 Aug;15(4):203-210.
- doi: 10.4196/kjpp.2011.15.4.203
Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cAMP levels and activates protein kinase A, thereby inhibiting vascular smooth muscle cell (VSMC) proliferation. We investigated whether AMP-activated... -
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- Protein Kinase C-delta Mediates Nitric Oxide- induced Proliferation of Gastric Cancer Cells, MKN-2
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Kim HH, Park KJ, Kwak JY
- KMID: 2004571
- J Korean Surg Soc.
- 2003 Mar;64(3):194-200.
PURPOSE: The purpose of this study was to investigate the effect of exogenous nitric oxide (NO) on the proliferation of gastric carcinoma cells and the signaling pathways that regulate these... -
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- Cell Cylce Regulatory Effects of Cyclic AMP in Cancer Cells Which Lack Wild-type p53
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Jang JS, Kang JH, Park BK, Hwang SG
- KMID: 2007092
- J Korean Cancer Assoc.
- 2000 Aug;32(4):750-756.
PURPOSE: The activator of protein kinase A, cyclic AMP, has been a recognized growth inhibitor of certain cell types. The present study aimed to investigate the effects of dibutyryl cAMP... -
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- cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells
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Park JY, Juhnn YS
- KMID: 2375027
- Exp Mol Med.
- 2017 Feb;49(2):e297.
- doi: 10.1038/emm.2016.152
This study was performed to investigate the signaling pathway that mediates cyclic AMP (cAMP)-induced inhibition of histone deacetylase 8 (HDAC8) degradation, and the effect and underlying mechanisms of the resulting... -
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- MSK1 regulates RANKL-induced NFATc1 expression through CREB and c-Fos
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Ha J, Hwang JH, Kwon SG, Park DH, Kim TW, Kang DG, Kang KH, Kim IS, Kim CW
- KMID: 2286279
- J Biomed Res.
- 2015 Jun;16(2):35-39.
- doi: 10.12729/jbr.2015.16.2.035
Osteoclasts originated from hematopoietic stem cells are multi-nucleated cells that can resorb the bone matrix. Receptor activator of nuclear factor kappa-B (RANK)/RANK ligand (RANKL) signaling pathway is crucial for the... -
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- Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts
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Jang IS, Rhim JH, Park SC, Yeo EJ
- KMID: 1111406
- Exp Mol Med.
- 2006 Apr;38(2):134-143.
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid... -
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- Augmentation of Regional Cerebral Blood Flow Response by Repeated Administration of Methamphetamine in Rat
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Jang WS, Kim JG, Park JD, Choi HK, Chung HS, Ko SY, Lee WS
- KMID: 2286951
- Korean J Psychopharmacol.
- 2000 Jun;11(2):178-187.
OBJECTIVES: It was aimed to observe the regional cerebral blood flow (rCBF) response on methamphetamine challenge test in rats which were subjected to repeated administration of methamphetamine, and to investigate the mechanism(s)... -
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- cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus
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Yoo SB, Lee S, Lee JY, Kim BT, Lee JH, Jahng JW
- KMID: 1493966
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):333-337.
- doi: 10.4196/kjpp.2012.16.5.333
Gene expression of neuronal nitric oxide synthase (nNOS) changes in the hypothalamic paraventricular nucleus (PVN) depending on feeding conditions, which is decreased during food deprivation and restored by refeeding, and... -
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- Effects of hydrogen peroxide on voltage-dependent K+ currents in human cardiac fibroblasts through protein kinase pathways
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Bae H, Lee D, Kim YW, Choi J, Lee HJ, Kim SW, Kim T, Noh YH, Ko JH, Bang H, Lim I
- KMID: 2285604
- Korean J Physiol Pharmacol.
- 2016 May;20(3):315-324.
- doi: 10.4196/kjpp.2016.20.3.315
Human cardiac fibroblasts (HCFs) have various voltage-dependent K+ channels (VDKCs) that can induce apoptosis. Hydrogen peroxide (H2O2) modulates VDKCs and induces oxidative stress, which is the main contributor to cardiac... -
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- Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
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Cho ES, Yu JH, Kim MS, Yim M
- KMID: 2158125
- Yonsei Med J.
- 2005 Feb;46(1):149-154.
- doi: 10.3349/ymj.2005.46.1.149
Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of... -
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- Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha
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Jang IS, Juhnn YS
- KMID: 755116
- Exp Mol Med.
- 2001 Mar;33(1):37-45.
Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein... -
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