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Cyclic ADP-ribose (cADPR) releases Ca²⺠from ryanodine receptor (RyR)-sensitive calcium pools in various cell types. In cardiac myocytes, the physiological levels of cADPR transiently increase the amplitude and frequency of...
Nam TS, Choi SH, Rah SY, Kim SY, Jang W, Im MJ, Kwon HJ, Kim UH
KMID: 1115950
Exp Mol Med.
2006 Dec;38(6):718-726.
ADP-ribosyl cyclase (ADPR-cyclase) produces a Ca2+-mobilizing second messenger, cyclic ADP- ribose (cADPR), from beta-NAD+. A prototype of mammalian ADPR-cyclases is a lymphocyte antigen CD38. Accumulating evidence indicates that ADPR-cyclases other...
Contraction of smooth muscle is initiated by an increase in
cytosolic Ca2+ leading to activation of Ca2+/calmodulin-dependnet myosin
light chain (MLC) kinase and phosphorylation of MLC. The types of
contraction and signaling mechanisms...