- Pharmacological evidence that cromakalim inhibits Ca2+ release from intracellular stores in porcine coronary artery
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Rhim BY, Hong SH, Kim CD, Lee WS, Hong KW
- KMID: 2285155
- Korean J Physiol Pharmacol.
- 1997 Feb;1(1):27-34.
In the present study, it was aimed to further identify the intracellular action mechanism of cromakalim and levcromakaliin in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine... -
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- Cromakalim blocks membrane phosphoinositide activated signals in the guinea pig lung mast cells stimulated with antigen-antibody reactions
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Ro JY, Kim JY, Kim KH
- KMID: 1562328
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):251-260.
Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by... -
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- The effects of cromakalim on the mediator releases from guinea pig lung mast cell activated by specific antigen-antibody reactions
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Ro JY, Yim YN, Kim KH
- KMID: 699910
- Yonsei Med J.
- 1996 Oct;37(5):325-338.
- doi: 10.3349/ymj.1996.37.5.325
The inhibitory effect of cromakalim on the mediator release from mast cells caused by antigenantibody reactions was in controversy with the specific antigen used. However, it has recently been observed... -
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- Ischemia-induced Changes of Biogenic Amines in Rat Brain and the Effect of Nimodipine of Them
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Park YK, Seo JT, Bahng HR, Kim KH
- KMID: 1686392
- J Korean Neurol Assoc.
- 1992 Dec;10(4):515-530.
It has been reported that ischernia causes changes in the concentration and tumover of monoamine neurotransmitters in brain. For the mechanism of cellular death in brain ischernia it is suggested... -
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- Effects of Diaxoxide, Cromakalim and Pinacidil on Acetylcholine and Norepinephrine Release in Rat Hippocampus
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Yang SH, Kim DK, Cho CG, Jeong JW, Choi BK
- KMID: 2461550
- J Korean Soc Endocrinol.
- 1994 Jun;10(2):115-124.
It is aim of the present study to gain more insight into the role K_ATP-channel in acetylcholine(Ach) and norepinephrine(NE) release in the central nervous system. Slices from the rat hippocampus... -
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- Vasomotor Reactivity of the Spasm Model by the Polystyrene Latex Bead
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Song KJ, Kang SD
- KMID: 2339675
- J Korean Neurosurg Soc.
- 2002 Apr;31(4):352-356.
OBJECTIVE: It has been reported that the presence of a pharmacologically inactive foreign substance, polystyrene latex bead, in subarachnoid space activates a non-specific immunological response and elicits arterial narrowing. In... -
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- Study on the Mechanism of Hypoxic Induced Vasodilatation and Vasoconstriction
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Kang BS, Lee YH
- KMID: 1858315
- Korean Circ J.
- 1998 Dec;28(12):2011-2029.
- doi: 10.4070/kcj.1998.28.12.2011
BACKGROUND: Although hypoxic pulmonary vasoconstriction (HPC) and hypoxic coronary vasodilatation (HCD) have been recognized by many researchers, the precise mechanism remains unknown. As isolated arteries will constrict or relax in... -
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- Depolarizing Mechanisms of Acetylcholine in Gastric Smooth Muscle
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Jun JY, Yeum CH, Moon SH, Oh HK, Park YW, Lee SJ, Yun PJ
- KMID: 2240620
- Korean J Gastroenterol.
- 1998 Apr;31(4):421-431.
BACKGROUND AND AIMS: Acetylcholine which is a major excitatory neurotransmitter, depolarizes gastric smooth muscle cells. The aim of this study was to investigate the ionic mechanisms of acetylcholine-induced depolarization in... -
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- Actions of potassium channel openers in rat detrusor urinae
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Kim SJ, Kim NS, Lee JL
- KMID: 1421952
- J Korean Med Sci.
- 1993 Feb;8(1):53-59.
- doi: 10.3346/jkms.1993.8.1.53
This study was performed to investigate the action of potassium channel openers on the mechanical activity of detrusor muscle isolated from rats. Detrusor muscle strips, 15 mm in length, were... -
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- Characteristics of Potassium Channel in the Isolated Rat Detrusor Muscle
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Jang MS, Choi EM, Ha JH, Lee KY, Kim WJ
- KMID: 2352252
- Yeungnam Univ J Med.
- 1994 Dec;11(2):363-374.
- doi: 10.12701/yujm.1994.11.2.363
The purpose of this study was to investigate the characteristics or the potassium channels existing in the rat urinary bladders. Smooth muscle strips of rat detrusor urinae were examined by isometric... -
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- Influences of Free Fatty Acids on Transmembrane Action Potential and ATP-sensitive Potassium Channel Activity in Rat Myocardium
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Kim JH, Ju JM, Park J, Baik YH, Kook H, Jeong HS, Jeong MH, Cho JG, Park JC, Kang JC
- KMID: 2093795
- Korean Circ J.
- 2000 Dec;30(12):1589-1589.
- doi: 10.4070/kcj.2000.30.12.1589
BACKGROUND: To evaluate the role of free fatty acids on the ischemic myocardium, influences of various free fatty acids upon transmembrane action potential and ATP-sensitive K+(KATP) channel activity were examined... -
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- Effects of Potassium Channel Modulators on Contractile Responses of Isolated Rat Vas Deferens to Field Stimulation
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Baik YH, Kim YM, Rhu BS
- KMID: 1973325
- Chonnam Med J.
- 2002 Mar;38(1):17-23.
Apart from regulating the resting membrane potential, K+ channels might also participate in cellular activity in response to endogenous neurotransmitters and exogenous agents. K+ channel modulators including 4 - aminopyridine... -
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- In vitro pharmacological characteristics of SKP-450, a novel K+ channel opener, in non-vascular smooth muscles in comparison with levcromakalim
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Hong KW, Park JY, Kim HH, Yoo SE
- KMID: 2285194
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):759-767.
In the present study, we characterized the non-vascular smooth muscle relaxant effects of a novel benzoyran derivative, SKP-450 (2-(2"(1",3"-dioxolone)-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro- 2H-1-benzopyran) and its metabolite, SKP-310, in comparison with levcromakalim (LCRK). In the rat stomach fundus,... -
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- Effect of the K+ Channel Modulations on Glutamate and K+ Concentrations in Rabbit Hippocampus during Transient Global Ischemia
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Choi KT, Cho MW, Suh BT, Lee JR, Park HS, Ryu PD
- KMID: 2032296
- Korean J Anesthesiol.
- 1999 Mar;36(3):510-517.
- doi: 10.4097/kjae.1999.36.3.510
BACKGROUND: Cerebral ischemia causes an increase in extracellular potassium ([K+]e) through activation of the KATP channel. This increase in [K+]e could result in neuronal depolarization and a reversal of the... -
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- The Mechanism on the Glutamate-evoked Release of [3H) norepinephrine in Rat Cortex Slices
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Shin BS, Song DW, Lee SH, Seo MW, Kim YH
- KMID: 2066064
- J Korean Neurol Assoc.
- 1996 Mar;14(1):238-250.
Glutamate Is the predominant excitatory neurotransmitter in the mammalian CNS. To elucidate the influence of glutamate on the noradrenergic neurotransmission in rat cortex, we examined the effects of agents that... -
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- Vascular Smooth Muscle Adenosine Triphosphate (ATP)-Sensitive Potassium Channel and Anesthetics
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Sohn JT
- KMID: 2238967
- Korean J Anesthesiol.
- 2002 Sep;43(3):263-273.
- doi: 10.4097/kjae.2002.43.3.263
Adenosine triphosphate-sensitive potassium channel (KATP channel) closed by intracellular adenosine triphosphate (ATP) appears widely distributed in the vascular system. Activation of vascular smooth muscle KATP channel with hyperpolarizing agents such... -
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- ATP-sensitive K+ currents in gastric myocytes isolated from guinea-pig
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Jun JY, Yeum CH, Yun PJ, Park JS, Kim SJ, So I, Kim KW
- KMID: 2071528
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):85-93.
ATP-sensitive K+ channels (KATP) were not identified in gastric smooth muscle cells. However, in tension recording of intact gastric circular muscle, lemakalim of KATP channels opener in other tissues suppressed mechanical contractions and... -
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