- Diagnostic Utility of Multiprobe Fluorescence in situ Hybridization Assay for Detecting Cytogenetic Aberrations in Acute Leukemia
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Kim BR, Choi JL, Kim JE, Woo KS, Kim KH, Kim JM, Kim SH, Han JY
- KMID: 1791920
- Ann Lab Med.
- 2014 May;34(3):198-202.
- doi: 10.3343/alm.2014.34.3.198
BACKGROUND: Specific cytogenetic aberrations detected by conventional karyotyping or FISH play a major role in the diagnosis, prognosis, and treatment of patients with acute leukemia. The FISH technique enhances the... -
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- Clinical Utility of Fluorescence in-situ Hybridization Profile Test in Detecting Genetic Aberrations in Acute Leukemia
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Kim SR, Kim HJ, Kim SH
- KMID: 1077410
- Korean J Lab Med.
- 2009 Oct;29(5):371-378.
- doi: 10.3343/kjlm.2009.29.5.371
BACKGROUND: Cytogenetic abnormalities are one of the most reliable prognostic factors in acute leukemia. Combination of conventional chromosome analysis (CCA) and FISH provides higher sensitivity in detecting these genetic abnormalities,... -
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- Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia
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Kim J, Lyu CJ, Shin S, Lee ST, Choi JR
- KMID: 2373579
- Ann Lab Med.
- 2016 Sep;36(5):475-480.
- doi: 10.3343/alm.2016.36.5.475
BACKGROUND: Intrachromosomal amplification of chromosome 21 (iAMP21) is known to be associated with poor prognosis in B-cell ALL (B-ALL). To determine the frequency and clinical characteristics of iAMP21 in Korean... -
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- Spectra of Chromosomal Aberrations in 325 Leukemia Patients and Implications for the Development of New Molecular Detection Systems
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Choi HJ, Kim HR, Shin MG, Kook H, Kim HJ, Shin JH, Suh SP, Ryang DW
- KMID: 1094259
- J Korean Med Sci.
- 2011 Jul;26(7):886-892.
- doi: 10.3346/jkms.2011.26.7.886
This study investigated the spectrum of chromosomal abnormalities in 325 leukemia patients and developed optimal profiles of leukemic fusion genes for multiplex RT-PCR. We prospectively analyzed blood and bone marrow... -
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