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Increasing the alpha 2, 6 Sialylation of Glycoproteins May Contribute to Metastatic Spread and Therapeutic Resistance in Colorectal Cancer

Park JJ, Lee M

  • KMID: 1712321
  • Gut Liver.
  • 2013 Nov;7(6):629-641.
Abnormal glycosylation due to dysregulated glycosyltransferases and glycosidases is a key phenomenon of many malignancies, including colorectal cancer (CRC). In particular, increased ST6 Gal I (beta-galactoside alpha 2, 6 sialyltransferase)...
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Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells

Oh SY, Park KS, Kim AJ, Choi KY

  • KMID: 1093594
  • Exp Mol Med.
  • 2002 Mar;34(1):27-31.
Activation of the extra cellular signal regulated kinase (ERK) pathway is involved in both proliferation and growth arrest of cells depending on intensity and duration of stimuli. In this study,...
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Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study

Kim YS, Shin JH, Bae MK, Lee CY, Kim DJ, Chung KY, Lee JG

PURPOSE: Autophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence...
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Expression of Cyclooxygenase-2 and its Relationship to p53 Accumulation in Colorectal Cancers

Lim SC, Lee TB, Choi CH, Ryu SY, Kim KJ, Min YD

PURPOSE: Cyclooxygenase (COX)-2 is an inducible isoform responsive to cytokines, mitogens, and growth factors, and is believed to be an important enzyme related to colorectal cancer (CRC). Existing evidence suggests...
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Reduced E-Cadherin Expression as a Cause of Distinctive Signet-Ring Cell Variant in Colorectal Carcinoma

Kim HC, Kim HJ, Kim JC

Colorectal signet-ring cell carcinoma (SRCC) is a rare type of adenocarcinoma and presents with distinctive clinicopathological features. This study was performed to assess the biological characteristics of colorectal SRCC regarding...
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Dipeptidyl Peptidase 10, a Novel Prognostic Marker in Colorectal Cancer

Park HS, Yeo HY, Chang HJ, Kim KH, Park JW, Kim BC, Baek JY, Kim SY, Kim DY

PURPOSE: The dipeptidyl peptidase IV (DPPIV) gene family exhibits multiple functions and is involved in the pathogenesis of various diseases. It has attracted pharmaceutical interest in the areas of metabolic...
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Coexpression of MUC1 with p53 or MUC2 correlates with Lymph Node Metastasis in Colorectal Carcinomas

Jang KT, Chae SW, Sohn JH, Park HR, Shin HS

The alteration of the mucin profile have been known to play a role in colorectal carcinogenesis. MUC1 is up-regulated and MUC2 is down-regulated in colorectalcarcinomas. Overexpression of p53 is frequently...
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Relationships Between the Expressions of CDX1 and CDX2 mRNA and Clinicopathologic Features in Colorectal Cancers

Kim GH, Lee DH, Kim HW, Cheong JY, Seo SB, Heo J, Kang DH, Song GA, Cho M, Yang US, Park DY, Yoo MA

BACKGROUND: CDX1 and CDX2 are members of the caudal-type homeobox gene family and control the proliferation and differentiation of intestinal mucosal cells. Their expressions are commonly reduced in colorectal cancer,...
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Expression of Cdx2 Protein in Colorectal Cancer

Pack JH, Kim TD, Oh HA, Lee EJ, Kim JW, Jang BI, Kim TN, Jung MK, Bae YK

  • KMID: 935212
  • Korean J Gastroenterol.
  • 2005 Sep;46(3):204-210.
BACKGROUND/AIMS: The caudal-related homeobox transcription factor, Cdx2, plays an important role in proliferation and differentiation of intestinal epithelial cells. Its expression is confined to normal and neoplastic intestinal epithelium. We...
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