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Current Recommendations for Laboratory Testing and Use of Bone Turnover Markers in Management of Osteoporosis

Lee J, Vasikaran

Osteoporosis is a major health problem worldwide, and is projected to increase exponentially due to the aging of the population. The absolute fracture risk in individual subjects is calculated by...
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Effect of Combined Sex Hormone Replacement on Bone/Cartilage Turnover in a Murine Model of Osteoarthritis

Yang JH, Kim JH, Lim DS, Oh KJ

BACKGROUND: Estrogens act on estrogen receptors distributed in articular cartilages, synovial membrane, and ligaments, which are thought to be related with degenerative changes. Meanwhile, progesterone is known to have a...
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Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use

Lim MJ, Kwon SR, Joo K, Son MJ, Park SG, Park W

BACKGROUND/AIMS: Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients. METHODS: Thirty-three active RA...
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Acute Effects of Intravenous Administration of Pamidronate in Patients with Osteoporosis

Lim MJ, Kwon SR, Park SG, Park W

We investigated acute effects of intermittent large dose bisphophonate therapy in osteoporotic patients. Peripheral blood mononuclear cells were incubated with alendronate (100 micrometer) for 18 hr, in vitro and cytokine...
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