- Multiple Regulation of Roundabout (Robo) Phosphorylation in a Heterologous Cell System
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Park HT
- KMID: 1611238
- Korean J Physiol Pharmacol.
- 2004 Apr;8(2):111-115.
Roundabout (Robo) is the transmembrane receptor for slit, the neuronal guidance molecule. In this study, the tyrosine phosphorylation of Robo was observed in Robo-transfected human embryonic kidney cells and developing... -
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- Effect of endothelin-1 on proliferation and differentiation of rat tracheal epithelial cells
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Kim CS, Oh SO, Woo JS, Jung JS, Kim YK, Lee SH
- KMID: 2071835
- Korean J Physiol Pharmacol.
- 1998 Dec;2(6):763-770.
A number of substances involved in the proliferation and differentiation of the tracheobronchial epithelium have been identified. The defects in the control of the proliferation and differentiation of tracheobronchial epithelial cells appear to constitute... -
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- Role of Protein Kinase in Spontaneous Phasic Contraction of Cat Gastric Smooth Muscle
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Sim SS, Choi JC, Kim MS, Kim CJ, Jo YH
- KMID: 2240381
- Korean J Gastroenterol.
- 2000 Mar;35(3):283-290.
Gastric muscle contraction is known to be regulated by complicated mechanism. In the present study, the role of protein kinase in the modulation of spontaneous gastric phasic contraction was investigated. METHODS: Circular muscle... -
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- Mechanism of the Potentiating Effect of Secretin-CCK in Rat Pancreas
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Lee DK, Kim JM, Kwon SO, Park KS, Chung JB, Kang JK, Kim KH
- KMID: 2143777
- Korean J Gastroenterol.
- 1997 Mar;29(3):380-393.
BACKGROUND/AIMS: The rnechanism of secretin and CCK potentiation effect was evaluated in the dispersed pancreatic acini of rat. METHODS: To observe the presence of potentiating effect of secretin and insulin... -
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- Phorbol Esters Attenuate The Action of Isoproterenol on Vascular Smooth Muscle
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Kim BY, Lee YW
- KMID: 2187899
- J Korean Neurosurg Soc.
- 1995 Jul;24(7):743-752.
The effects of phorbol esters were studied in rabbit carotid artery to evaluate the action of protein kinase C on the regulation of vascular tone by isoproterenol. The vascular rings,... -
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- Effects of histamine H|2-receptor stimulation on Mg2+ efflux in perfused guinea pig heart
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Kang HS, Chang SE, Kang CW, Chae SW, Kim JS
- KMID: 2071523
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):49-54.
Mg2+ is an important regulator of many cardiac functions. However, regulation of intracellular Mg2+ activity in the heart is not well characterized. To assess the effect of histamine H2-receptor stimulation on intracellular Mg2+... -
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- Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons
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Jang IS, Akaike N
- KMID: 1614991
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):63-70.
Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the... -
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- Expression of signal transducing G proteins in human melanoma cell lines
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Lee ES, Kang WH, Jin YH, Juhnn YS
- KMID: 1532666
- Exp Mol Med.
- 1997 Dec;29(4):223-227.
Some malignant melanoma cells regress spontaneously by terminal differentiation, and understanding the mechanisms of this spontaneous regression can contribute to the development of a new therapy not only for melanoma... -
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- Characterization of Cyclic AMP Response Element (CRE) in the Promoter of the Rat Thyrotropin Releasing Hormone (TRH) Gene
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Jung WW, Yang IM, Seo KS, Jung SW
- KMID: 2461510
- J Korean Soc Endocrinol.
- 1994 Sep;9(3):190-199.
We investigated whether the two variant elements of CRE(TGcCGTCA[5'CRE], TGACcTCA[3'CRE]) in the 5'flanking region of the rat TRH gene, which are different from the CRE consensus sequence(5'-TGACGTCA-3') by one base... -
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- Effect of Somatostatin on Cholecystokinin-Induced Amylase Release in Rat Pancreatic Acini
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Rhie DJ, Choi WS, Yi SY, Yoon SH, Hahn SJ, Sim SS, Kim MS, Jo YH
- KMID: 2304683
- Korean J Gastroenterol.
- 1998 Dec;32(6):773-781.
BACKGROUND/AIMS: The inhibitory effect of somatostatin (SS) on cholecystokinin (CCK)-induced amylase release and the role of intracellular cAMP in this process were investigated. METHODS: Pancreatic acini were isolated from rat pancreas... -
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- Regulation of immediate early gene expression by glutamate receptor activation in C6 rat glioma cells
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Lee JK, Kim YH, Choi SS, Suh HW
- KMID: 1606834
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):19-25.
We have studied the effects of excitatory amino acids on the expression of the c-fos and c-jun mRNA in rat C6 glioma cells. The glutamate, N-methyl-D-aspartate (NMDA), and kainic acid (KA) increased... -
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- Effects of overexpression of stimulatory G proteins on the expression of the other G proteins in COS-1 cells
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Kim SY, Jang IS, Yang JM, Kwak SJ, Juhnn YS
- KMID: 2045610
- Exp Mol Med.
- 1997 Jun;29(2):133-137.
To investigate the interaction of stimulatory GTP binding protein (G(s)) pathways with others, we overexpressed wild type alpha subunit of G(s) (G(s) alpha), constitutively activated R201E G(s) alpha, and dominant... -
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- Modulation of L-type Ca2+ channel currents by various protein kinase activators and inhibitors in rat clonal pituitary GH3 cell line
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Bae YM, Baek HJ, Cho HN, Earm YE, Ho WK
- KMID: 2285234
- Korean J Physiol Pharmacol.
- 2001 Apr;5(2):139-146.
L-type Ca2+ channels play an important role in regulating cytosolic Ca2+ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated... -
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- Vasomotor Reactivity of the Spasm Model by the Polystyrene Latex Bead
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Song KJ, Kang SD
- KMID: 2339675
- J Korean Neurosurg Soc.
- 2002 Apr;31(4):352-356.
OBJECTIVE: It has been reported that the presence of a pharmacologically inactive foreign substance, polystyrene latex bead, in subarachnoid space activates a non-specific immunological response and elicits arterial narrowing. In... -
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- Role of Protein kinase C in Desensitization of Somatostatin-induced Calcium Signalling in NG108-15 Cells
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Kim KM, Sung JH, Kim MJ, Rhie DJ, Jo YH, Hahn SJ, Kim MS, Yoon SH, Kim BS
- KMID: 2100466
- J Korean Soc Endocrinol.
- 2005 Aug;20(4):353-361.
- doi: 10.3803/jkes.2005.20.4.353
BACKGROUND: Activation of G-protein coupled-somatostatin receptors induces the release of calcium from inositol 1, 4, 5-trisphosphate-sensitive intracelluar stores. G-protein-coupled receptor signaling decreases with prolonged exposure to an agonist. SEBJECTS and... -
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- Cyclophosphamide-induced HCN1 channel upregulation in interstitial Cajal-like cells leads to bladder hyperactivity in mice
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Liu Q, Long Z, Dong X, Zhang T, Zhao J, Sun B, Zhu J, Li J, Wang Q, Yang Z, Hu X, Li L
- KMID: 2382710
- Exp Mol Med.
- 2017 Apr;49(4):e319.
- doi: 10.1038/emm.2017.31
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are confirmed to be expressed in bladder interstitial Cajal-like cells (ICC-LCs), but little is known about their possible role in cystitis-associated bladder dysfunction. The present... -
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- Changes in the Rate of Renin Secretion During Cell Cycle of As 4.1 Cells
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Kim MK, Kim MH, Chang JW, Leem CH, Jang YJ, Park CS
- KMID: 2079304
- Korean J Nephrol.
- 2003 Sep;22(5):512-521.
BACKGROUND: Renin is secreted from the juxtaglomerular (JG) cells in response to a wide variety of extracellular stimuli. To study the underlying mechanism of regulation of renin secretion at molecular... -
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- Regulation of Steroid Thyroid Hormone Receptor 3 (TR3) mRNA Expression by Luteinizing Hormone in Human Early Luteinized Granulosa Cells
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Park HJ, Kim BR, Chun SY, Lee YI
- KMID: 2128995
- Korean J Obstet Gynecol.
- 2002 Oct;45(10):1736-1745.
OBJECTIVE: The present study examined the gonadotropin regulation of TR3 gene expression by luteinizing hormone (LH) in cultured human luteinized granulosa cells. METHODS: TR3 mRNA levels were detected by competitive... -
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- Regulation of FSH Gene Expression and Release in Cultured Rat Anterior Pituitary Cells
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Cheon MS, Park DB, Park YB, Kam KY, Ryu KZ
- KMID: 2199610
- J Korean Soc Endocrinol.
- 2000 Jun;15(2):179-189.
BACKGROUND: FSH is a heterodimeric glycoprotein and is composed of alpha and beta subunits. alpha subunit is common to FSH and LH, while an unique beta subunit determines the biological... -
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- PKA-Mediated Regulation of B/K Gene Transcription in PC12 Cells
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Choi MH, Kim HS, Choi SH, Kim MY, Jang YS, Jang YM, Lee JH, Jeong SW, Kim IK, Kwon OJ
- KMID: 2071616
- Korean J Physiol Pharmacol.
- 2005 Dec;9(6):333-339.
B/K protein is a novel protein containing double C2-like domains. We examined the specific signaling pathway that regulates the transcription of B/K in PC12 cells. When the cells were treated... -
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