- A Case of Chronic Myelogenous Leukemia with ider(22)(q10)t(9;22)(q34;q11.2) as Clonal Evolution
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Kim EH, Cho HS, Lee CH, Kim KD, Hyun MS, Bae SH
- KMID: 2239565
- Korean J Lab Med.
- 2003 Jun;23(3):139-142.
The ider(22)(q10)t(9;22)(q34;q11.2) is a rare secondary karyotypic aberration of Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) and was associated with disease progression and poor clinical outcomes in most of... -
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- Granulocytic dysplasia: an indicator of clonal evolution in patients with chronic myeloid leukemia
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Rajpal S, Nampoothiri RV, Sreedharanunni S, Parihar M, Malhotra P, Varma N
- KMID: 2451043
- Blood Res.
- 2018 Jun;53(2):180-181.
- doi: 10.5045/br.2018.53.2.180
No abstract available. -
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- Coexisting with Clonal Evolution and BCR-ABL Mutant in CML Patients Treated with Second-generation Tyrosine Kinase Inhibitors Predict the Discrepancy of in vitro Drug Sensitivity
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Ahn JS, Kim YK, Lee SR, Yu L, Yang DH, Cho SH, Shim HJ, Bae WK, Lee JJ, Chung IJ, Shin MG, Kim HJ
- KMID: 2165975
- Cancer Res Treat.
- 2010 Mar;42(1):37-41.
PURPOSE: Second-generation tyrosine kinase inhibitors (second TKIs) such as nilotinib and dasatinib control the activity of most ABL kinase domain mutations observed in patients with imatinib resistance. Although in vitro... -
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- Analysis of Clonal Chromosome Abnormalities in Acute Myeloid Leukemia at Diagnosis, in Remission, and in Relapse
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Han JY, Kim KH, Lee YH, Kim JS, Kim HJ, Lee EY
- KMID: 1931942
- Korean J Clin Pathol.
- 2000 Feb;20(1):1-6.
BACKGROUND: Approximately two thirds of acute myeloid leukemia(AML) have recognizable clonal chromosome abnormalities. We have performed the cytogenetic monitoring of 35 de novo AML to follow the karyotype changes at... -
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- A t(3;3)(q21;q26) Acute Myeloid Leukemia with the Philadelphia Chromosome as a Secondary Change
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Han JY, Kim KH, Kim JS, Kim HJ, Nam R
- KMID: 1537194
- Korean J Hematol.
- 2000 Feb;35(1):67-71.
The Philadelphia chromosome (Ph) appears as a secondary change at the onset of disease. However, a late-appearing or secondary Ph has also been observed in rare cases of chronic myeloid... -
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- Single-Cell Sequencing in Cancer: Recent Applications to Immunogenomics and Multi-omics Tools
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Sierant MC, Choi J
- KMID: 2439207
- Genomics Inform.
- 2018 Dec;16(4):e17.
- doi: 10.5808/GI.2018.16.4.e17
Tumor heterogeneity, the cellular mosaic of multiple lineages arising from the process of clonal evolution, has continued to thwart multi-omics analyses using traditional bulk sequencing methods. The application of single-cell... -
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- Aplastic Anemia
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Kook H
- KMID: 2064968
- J Korean Med Assoc.
- 2006 Oct;49(10):885-896.
- doi: 10.5124/jkma.2006.49.10.885
Aplastic anemia (AA) is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. The pathophysiology of acquired AA is immune-mediated in most cases. Activated type 1... -
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- Gastric stem cells and gastric cancer stem cells
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Han ME, Oh SO
- KMID: 2046753
- Anat Cell Biol.
- 2013 Mar;46(1):8-18.
- doi: 10.5115/acb.2013.46.1.8
The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells,... -
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- A Case of Malignant Duodenal Stromal Tumor
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Jeon BC, Jeong MY, Suh JI, Yang CH, Kim SC, Lee CW, Jeong BW, Kim JR, Bae HI
- KMID: 2143764
- Korean J Gastroenterol.
- 1998 Jan;31(1):124-129.
Malignant stromal tumors of the small intestinal tract are uncommon and their clinical behavior is notoriously unpredictable. Gastrointestinal stromal tumors are spindle cell tumors occurring mainly in adults with 5-year... -
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- Serial Determination of FLT3-ITD and NPM1 Mutations and Its Clinical Significance in Patients with MDS at Diagnosis and After Progression to AML with Myelodysplasia-related Changes
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Chung JW, Chi HS, Lee EH, Jang S, Seo EJ, Park CJ
- KMID: 2312180
- Lab Med Online.
- 2011 Jul;1(3):138-146.
BACKGROUND: Accumulation of genetic aberrations in MDS is closely associated with progression to AML. FLT3-ITD is commonly found in AML and less frequently in MDS. FLT3-ITD in MDS is associated... -
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- Aplastic anemia
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Kim HK
- KMID: 2278473
- Korean J Pediatr.
- 2007 Jun;50(6):519-523.
- doi: 10.3345/kjp.2007.50.6.519
Aplastic anemia is a rare disease, which is characterized by pancytopenia and hypocellular bone marrow without infiltration of abnormal cells or fibrosis. The incidence in Asia is higher than in... -
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- Personalized cancer medicine: present status and future perspectives
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Heo DS
- KMID: 2195131
- J Korean Med Assoc.
- 2015 Nov;58(11):1021-1026.
- doi: 10.5124/jkma.2015.58.11.1021
Most cancers have oncogenes and tumor suppressor genes. First successful drug targeting a oncogene is imatinib. It was very effective for chronic myelogenous leukemia as well as gastrointestinal stromal tumors.... -
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- Retrospective Analysis of Prognostic Factors Affecting Survival After Onset of Blastic Crisis of Chronic Myeloid Leukemia Especially Focused on FAB Classification
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Shin HJ, Chung JS, Lee EY, Kim JS, Kim HJ, Lee WS, Sohn CH, Cho GJ
- KMID: 2014034
- Korean J Hematol.
- 2003 May;38(2):119-126.
BACKGROUND: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by a progressive course outlined by the transition from the chronic phase (CP) to blastic crisis (BC). The course... -
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- Detection of Minimal Residual Disease by IgH gene rearrangement-PCR in Childhood Acute Lymphoblastic Leukemia
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Park CJ, Kim MC, Moon AR, Seo EJ, Chi HS, Seo JJ, Kim TH, Moon HN
- KMID: 2225841
- Korean J Clin Pathol.
- 1999 Apr;19(2):163-171.
BACKGROUND: The IgH gene rearrangement (IgH GR) involving highly specific CDR3 region can be used as a minimal residual disease marker in ALL. The IgH GR-PCR has the advantages of... -
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- T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia
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Kim H, Kim IS, Chang CL, Kong SY, Lim YT, Kong SG, Cho EH, Lee EY, Shin HJ, Park HJ, Eom HS, Lee H
- KMID: 2425967
- Ann Lab Med.
- 2019 Mar;39(2):125-132.
- doi: 10.3343/alm.2019.39.2.125
BACKGROUND: Chromosomal abnormalities and common genetic rearrangements related to T-acute lymphoblastic leukemia (T-ALL) are not clear. We investigated T-cell receptor (TCR) rearrangement in Korean T-ALL patients by fragment analysis, examining... -
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- Evaluation of prognostic factors in patients with relapsed AML: Clonal evolution versus residual disease
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Kim H, Seol YM, Song MK, Choi YJ, Shin HJ, Park SH, Lee EY, Chung JS
- KMID: 2353498
- Blood Res.
- 2016 Sep;51(3):175-180.
- doi: 10.5045/br.2016.51.3.175
BACKGROUND: It is widely known that the prognosis of acute myeloid leukemia (AML) depends on chromosomal abnormalities. The majority of AML patients relapse and experience a dismal disease course despite... -
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- Analyses of the TCR repertoire of MHC class II-restricted innate CD4+ T cells
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Kang BH, Min HS, Lee YJ, Choi B, Kim EJ, Lee J, Kim JR, Cho KH, Kim TJ, Jung KC, Park SH
- KMID: 2155419
- Exp Mol Med.
- 2015 Mar;47(3):e154.
- doi: 10.1038/emm.2015.7
Analysis of the T-cell receptor (TCR) repertoire of innate CD4+ T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4+ T cells) is essential for... -
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