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Delta Neutrophil Index as an Early Marker for Distinguishing Myeloid from Childhood Acute Leukemia

Hong JP, Kim S, Kim BR, Yoon SH, Hahn SM, Kim MK

BACKGROUND: The accurate and early diagnosis of acute myeloid leukemia (AML) is important to choose proper treatment option depending on the risk stratification. The delta neutrophil index (DNI) is a...
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Outcome and Prognostic Factors in Pediatric Precursor T-Cell Acute Lymphoblastic Leukemia: A Single-Center Experience

Rhee ES, Kim H, Kang SH, Yoo JW, Koh KN, Im HJ, Seo JJ

BACKGROUND: Precursor T-cell acute lymphoblastic leukemia (T-ALL) has worse prognosis than B-cell ALL. We aimed to evaluate prognostic variables in pediatric T-ALL. METHODS: Medical records of 36 T-ALL patients (27 males...
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A Case of Pediatric Unprovoked Deep Vein Thrombosis due to Combined Hereditary Thrombophilia of Antithrombin III and Protein S Deficiency

Kim JY, Kang IS, Kim HJ

Unprovoked deep vein thrombosis (DVT) is uncommon in pediatric patients and, among those, combined hereditary thrombophilia is particularly rare. We present a 9-year-old Korean boy who developed lower extremity pain...
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Joint Health Status in Hemophilia Patients Using Hemophilia Joint Health Score and Pettersson Score

Roh YY, Choi YH, Park M, Hahn JH, Kim SH, Shin YJ, Hahn SM, Lee HY, Park JM, Hong JP, Lyu CJ, Han JW

BACKGROUND: Comprehensive clinical and radiologic follow-up is needed to preserve joint functions and quality of life in hemophilia using clinimetric tools such as Hemophilia joint health score (HJHS) or Pettersson...
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Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report

Hong HJ, Cho YH, Lim JY, Yeom JS, Park JS, Park ES, Seo JH, Woo HO, Youn HS

Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic...
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Two Pediatric Cases of Spontaneous Ruptured Solid Tumors Successfully Treated with Transcutaneous Arterial Embolization

Jo KJ, Yang EJ, Park KM, Kim JH, Jeon UB, Jang JY, Lim YT

Spontaneous rupture with internal bleeding of solid tumors has rarely been described at the time of diagnosis or during chemotherapy. This rare event must be regarded as a life threatening...
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A Case of Transient Myeloproliferative Disorder Associated with Clonal Trisomy 21 in a Chromosomally Normal Newborn

Park J, Hong YR, Kong SG

Transient myeloproliferative disorder (TMD) is similar to congenital leukemia, with leukocytosis, increased peripheral blast cells, and hepatomegaly in the neonatal period. Although TMD occurs only in patients with Down syndrome...
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A Study of Central Diabetes Insipidus in Head and Neck Langerhans Cell Histiocytosis: A Single Center Experience

Lee MJ, Park BS, Yoo YM, Jung HJ, Park JE

BACKGROUND: Langerhans cell histiocytosis (LCH) frequently involves the head and neck and increases the risk of central nervous system (CNS) involvement of LCH, such as central diabetes insipidus (CDI), when...
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Two Cases of Adjuvant Immunotherapy with Cytokine-Induced Killer Cells for Relapsed or Refractory Neuroblastoma

Choi JY, An HY, Hong KT, Hong C, Kang HJ, Shin HY

The treatment outcomes of relapsed or refractory neuroblastoma have been unsatisfactory till date. We reported two cases of adoptive immunotherapy using cytokine-induced killer (CIK) cells against relapsed or refractory neuroblastoma....
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Management of Spontaneous Spinal Epidural Hematoma Developed in Children with Hemophilia

Jang HN, Yoon HS, Park YS

Spinal epidural hematoma (SEH) is a rare neurosurgical emergency in which pressure on the spinal cord leads to acute neurological deficits, and is a rare complication in children with hemophilia....
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A Case of Ethosuximide-Induced Aplastic Anemia Successfully Treated with Methylprednisolone Pulse Therapy

Kang HS, Kim SH

Aplastic anemia may develop secondary to environmental exposure to entities such as chemicals, medical drugs, and infectious agents. Fatal complications from antiepileptic medications may occur despite careful and appropriate use....
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Characteristic Features of Pneumocystis Pneumonia in Pediatric Acute Lymphoblastic Leukemia

Kim H, Jang H, Kim YK, Kim D, Kim JY

BACKGROUND: Pneumocystis is difficult to culture or detect in laboratory environments. Its ecology including the timing and method of transmission as well as environmental sources and communicability remain unclear. METHODS: We...
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Clinical Courses and Outcome of Newly Diagnosed Immune Thrombocytopenia in Infants

Hwang NR, Park KD

BACKGROUND: Infants with immune thrombocytopenia (ITP) are at increased risk of high risk bleeding and vaccination-associated ITP. Infants with ITP respond favorably to treatment and are less likely to develop...
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The Efficacy of High Dose Dexamethasone Therapy in Children with Immune Thrombocytopenic Purpura

Lee HO, Chang SH, Baek HJ, Kim HS, Park SM, Shin MG, Kook H

BACKGROUND: Few studies of high dose dexamethasone (HD-DXM) therapy in children with immune thrombocytopenic purpura (ITP) have been reported. The purpose of this study is to investigate efficacy and safety...
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Clinical Course of Neutropenia in Previously Healthy Children

Kim DH, Lee JH, Yoon HS

BACKGROUND: Neutropenia can be easily found in previously healthy children associated with various medical conditions, and the clinical course ranges from transient benign to life threatening. This study aimed to...
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Predictive Value of Endometrial Thickness for Anemia in Adolescent Girls with Abnormal Uterine Bleeding

Lee JS, Cho YH, Jeon IS

BACKGROUND: Immaturity of the endocrine system that controls the normal menstrual cycle frequently results in abnormal uterine bleeding (AUB) and elicits anemia in adolescent girls. This study was conducted to...
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Outcome of Hematopoietic Stem Cell Transplantation in Wiskott-Aldrich Syndrome

Kim BK, Hong KT, Kang HJ, Choi JY, An HY, Shin HY

BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a very rare disease and patients who do not receive timely treatment suffer from bleeding, infection, and malignancy. Hematopoietic stem cell transplantation (HSCT) has been...
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Clinical Significance of Random Urinary Vanillylmandelic Acid in Patients with Neuroblastoma

Park E, Park H, Cho H, Ma Y, Lee SY, Lee JW, Yoo KH, Sung KW, Koo HH

BACKGROUND: To evaluate the value of random urinary vanillylmandelic acid (VMA) as a surrogate marker for monitoring tumor response and predicting outcome in patients with neuroblastoma (NB). METHODS: Medical records of...
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Disulfram Treatment of NUP98-PHF23 AML Is Not Effective In Vivo: Potential Role for Hematopoietic Stem Cells Niche

Park ES, Chung YJ, Aplan PD

BACKGROUND: NUP98 has numerous partner genes of which plant homeodomain (PHD) finger protein 23 (PHF23) fusion with NUP98 (NP23) can be detected by RT-PCR in patients with cytogenetically normal acute...
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