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Oral Rivaroxaban Treatment for L-asparaginase-induced Deep Thrombophlebitis in Lower Extremity

Kim JE, Kim JY

We are reporting our experience of oral rivaroxaban (Xarelto(R)) treatment for L-asparaginase (L-ASP)-induced deep vein thrombophlebitis in the lower extremity developed during childhood acute lymphoblastic leukemia (ALL) chemotherapy, with a...
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A Case of Nasal Type Extranodal NK/T Cell Lymphoma Incidentally Detected in a Child

Oh HJ, Park SH, Jang HI, Lee DH, Choi YD, Baek HJ, Kook H

A nasal type extranodal NK/T-cell lymphoma (ENKL) is very rare in children. A pediatric nasal type ENKL is generally localized and is likely to have sensitivity to radiotherapy. The most...
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A Case of Vertebral Body Compression Fracture as an Initial Sign for Acute Lymphoblastic Leukemia

Kim D, Jeon IS

More than one third of patients may present with bone pain as a consequence of leukemic cell infiltration of bone, however, bone fracture itself is an unusual presentation for childhood...
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The Use of Rituximab with Immune Tolerance Induction Therapy for Hemophilia A with Inhibitors

Kim CY, Lee KN, Park YS

Inhibitor development is one of the major adverse events associated with increased morbidity and mortality in patients with congenital hemophilia. Recent treatment for them is immune tolerance induction (ITI), which...
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Aberrant DNA Methylation of CDH1, p16 and DAPK in Childhood Acute Lymphoblastic Leukemia

Hahn SM, Kwon SY, Kim HS, Han JW, Lyu CJ

BACKGROUND: Hypermethylation of tumor suppressor gene has been reported in various types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. METHODS: To evaluate the...
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The Characteristics of Severe Iron Deficiency Anemia in Children and Adolescents

Kwon HW, Kwon SE, Lee JE, Jun YH, Kim SK

BACKGROUND: Severe iron deficiency anemia (IDA) can cause developmental and growth problems in children and disease severity is more than cognitive disorder or diabetic neuropathy according to the disability weight...
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Recent Update in Hepatoblastoma

Park M

Hepatoblastoma, the most common primary liver tumor of early childhood, is a rare neoplasm, accounting for 0.8-2.0% of all pediatric cancers. The etiology is unknown. The most common method of...
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Diagnosis & Treatment of Retinoblastoma: Current Review

Chueh H

Retinoblastoma is a rare disease, but most common tumor which arises in eye. It can affect one or both eyes, and the main pathophysiology is explained by the "Two-hit theory"...
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Overview of Pediatric Extracranial Germ Cell Tumors

Lim YJ

Germ cell tumors the designation given to neoplasm arising from the cells of the germline, the cells that are destined to become either the egg or the sperm. These tumors...
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Wilms' Tumor

Park JE

Wilms' tumor, nephroblastoma is the most common renal tumor in children. Treatment outcomes have improved dramatically over the past few decades due to applying of multimodality therapy consisting of surgery,...
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Recent Updates in Langerhans Cell Histiocytosis

Koh KN, Im HJ, Seo JJ

Langerhans cell histiocytosis (LCH) encompasses a wide range of clinical presentation and its clinical course varies widely from spontaneous regression to severe disseminated disease with the risk of permanent consequences....
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Diagnosis and Treatment of Pediatric Acute Myeloid Leukemia

Lee JW, Cho B

Acute myeloid leukemia (AML) is a heterogeneous malignancy that comprises 25-30% of pediatric leukemias in Korea. Several inherited diseases, such as Down syndrome and Fanconi anemia, predispose towards AML leukemogenesis....
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Glucose-6-phosphate Dehydrogenase Deficiency

Lee JM

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder. There are more than 400 million people worldwide with G6PD deficiency, and its distribution is similar to that of malaria....
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