- Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond
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Nguyen DV, Vidal C, Chu HC, van Nunen
- KMID: 2454154
- Asia Pac Allergy.
- 2019 Jul;9(3):e20.
- doi: 10.5415/apallergy.2019.9.e20
Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%–50%) and... -
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- Validation of a Rapid, Robust, Inexpensive Screening Method for Detecting the HLA-B*58:01 Allele in the Prevention of Allopurinol-Induced Severe Cutaneous Adverse Reactions
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Nguyen DV, Vida C, Chu HC, Fulton R, Li J, Fernando S
- KMID: 2355897
- Allergy Asthma Immunol Res.
- 2017 Jan;9(1):79-84.
- doi: 10.4168/aair.2017.9.1.79
The HLA B*58:01 allele has been worldwide reported as a pharmacogenetic susceptibility to allopurinol-induced severe cutaneous adverse reactions (SCARs). To prevent these life-threatening conditions, the American College of Rheumatology hingly... -
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- HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in Vietnamese
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Nguyen DV, Chu HC, Nguyen DV, Phan MH, Craig T, Baumgart K, van Nunen
- KMID: 2397053
- Asia Pac Allergy.
- 2015 Apr;5(2):68-77.
- doi: 10.5415/apallergy.2015.5.2.68
BACKGROUND: In Vietnam, we observed a high incidence of carbamazepine (CBZ)-induced severe cutaneous adverse drug reactions (SCARs)-Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), and drug-induced hypersensitivity rash with eosinophilia and systemic... -
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