- Msi1-Like (MSIL) Proteins in Fungi
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Yang DH, Maeng S, Bahn YS
- KMID: 2312679
- Mycobiology.
- 2013 Mar;41(1):1-12.
Msi1-like (MSIL) proteins, which are eukaryote-specific and contain a series of WD40 repeats, have pleiotropic roles in chromatin assembly, DNA damage repair, and regulation of nutrient/stress-sensing signaling pathways. In the... -
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- RNA polymerase II carboxy-terminal domain with multiple connections
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Cho EJ
- KMID: 1047075
- Exp Mol Med.
- 2007 Jun;39(3):247-254.
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of... -
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- Epigenetic regulation and chromatin remodeling in learning and memory
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Kim S, Kaang BK
- KMID: 2367527
- Exp Mol Med.
- 2017 Jan;49(1):e281.
- doi: 10.1038/emm.2016.140
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the... -
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- The roles of ARID1A in gynecologic cancer
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Mao TL, Shih IM
- KMID: 2177880
- J Gynecol Oncol.
- 2013 Oct;24(4):376-381.
- doi: 10.3802/jgo.2013.24.4.376
One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of... -
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- Epigenetics and Psychiatric Disorders
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Oh D, Yang BH, Lee YS
- KMID: 2299915
- Korean J Biol Psychiatry.
- 2008 Nov;15(4):243-253.
In the post-genomic era, the mechanisms controlling activation of genes are thought to be more important. Gene-environment interactions are crucial in both development and treatment of psychiatric disorders as they... -
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- Molecular mechanisms of luteinization
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Sugino N
- KMID: 2313991
- Obstet Gynecol Sci.
- 2014 Mar;57(2):93-101.
Dynamic changes in steroidogenesis occur in ovarian granulosa cells during ovulation after the LH surge. The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid... -
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- The Wnt Signaling Pathway and Related Therapeutic Drugs in Autism Spectrum Disorder
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Bae SM, Hong JY
- KMID: 2412380
- Clin Psychopharmacol Neurosci.
- 2018 May;16(2):129-135.
- doi: 10.9758/cpn.2018.16.2.129
Autism spectrum disorder (ASD) is a series of neurodevelopmental disorder with a large genetic component. However, the pathogenic genes and molecular mechanisms of ASD have not been clearly defined. Recent... -
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- Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation
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Choi KY, Yoo M, Han JH
- KMID: 2070274
- Exp Mol Med.
- 2015 Apr;47(4):e155.
- doi: 10.1038/emm.2014.129
The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know... -
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- Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
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Giacone F, Cannarella R, Mongioì L, Alamo A, Condorelli RA, Calogero A, La Vignera S
- KMID: 2443230
- World J Mens Health.
- 2019 May;37(2):148-156.
- doi: 10.5534/wjmh.180071
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict... -
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- Molecular Mechanisms Governing IL-24 Gene Expression
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Sahoo A, Im SH
- KMID: 2014650
- Immune Netw.
- 2012 Feb;12(1):1-7.
- doi: 10.4110/in.2012.12.1.1
Interleukin-24 (IL-24) belongs to the IL-10 family of cytokines and is well known for its tumor suppressor activity. This cytokine is released by both immune and nonimmune cells and acts... -
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- Identification of a novel mutation in the CHD7 gene in a patient with CHARGE syndrome
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Kim Y, Lee HS, Yu JS, Ahn K, Ki CS, Kim J
- KMID: 1875960
- Korean J Pediatr.
- 2014 Jan;57(1):46-49.
- doi: 10.3345/kjp.2014.57.1.46
CHARGE syndrome has been estimated to occur in 1:10,000 births worldwide and shows various clinical manifestations. It is a genetic disorder characterized by a specific and a recognizable pattern of... -
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- IL-4 and HDAC Inhibitors Suppress Cyclooxygenase-2 Expression in Human Follicular Dendritic Cells
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Cho W, Hong SH, Choe J
- KMID: 1431929
- Immune Netw.
- 2013 Apr;13(2):75-79.
- doi: 10.4110/in.2013.13.2.75
Evidence for immunoregulatory roles of prostaglandins (PGs) is accumulating. Since our observation of PG production by human follicular dendritic cells (FDCs), we investigated the regulatory mechanism of PG production in... -
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- Atypical Teratoid Rhabdoid Tumour : From Tumours to Therapies
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Richardson EA, Ho B, Huang A
- KMID: 2417355
- J Korean Neurosurg Soc.
- 2018 May;61(3):302-311.
- doi: 10.3340/jkns.2018.0061
Atypical teratoid rhabdoid tumours (ATRTs) are the most common malignant central nervous system tumours in children ≤1 year of age and represent approximately 1–2% of all pediatric brain tumours. ATRT... -
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- Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells
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Park JA, Park S, Park WY, Han MK, Lee Y
- KMID: 2447221
- Int J Stem Cells.
- 2019 Mar;12(1):21-30.
- doi: 10.15283/ijsc18040
BACKGROUND AND OBJECTIVES: Embryonic stem (ES) cells have pluripotent ability to differentiate into multiple tissue lineages. SIRT1 is a class III histone deacetylase which modulates chromatin remodeling, gene silencing, cell... -
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- Transcriptional Mechanisms of Drug Addiction
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Nestler EJ
- KMID: 1432535
- Clin Psychopharmacol Neurosci.
- 2012 Dec;10(3):136-143.
- doi: 10.9758/cpn.2012.10.3.136
Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription factors, proteins that bind to... -
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- Normal Adult Hippocampal Neurogenesis in SRG3-overexpressing Transgenic Mice
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Kim B, Lee E, Seong RH, Chung H, Son H
- KMID: 2165318
- Exp Neurobiol.
- 2010 Jun;19(1):39-48.
- doi: 10.5607/en.2010.19.1.39
SRG3 (SWI3-related gene) is a core subunit of mouse SWI/SNF complex and is known to play a critical role in stabilizing the SWI/SNF complex by attenuating its proteasomal degradation. SWI/SNF... -
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- Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
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GasiÅ«nienÄ— M, Petkus G, MatuzeviÄius D, Navakauskas D, NavakauskienÄ— R
- KMID: 2465896
- Int J Stem Cells.
- 2019 Jul;12(2):251-264.
- doi: 10.15283/ijsc18126
BACKGROUND AND OBJECTIVES: Human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may be a valuable source for cardiovascular tissue engineering and cell therapy. The aim of this study is to verify... -
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- Aging and impaired hematopoiesis
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Shin MG
- KMID: 2064891
- J Korean Med Assoc.
- 2014 Apr;57(4):334-340.
- doi: 10.5124/jkma.2014.57.4.334
Aging is an universal phenomenon and irreversible syndrome, and its damage occurs to molecules (DNA, proteins, and lipids), to cells, and to organs. Hematopoietic tissue intrinsically has a very high... -
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- The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
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Yeo CD, Kang N, Choi SY, Kim BN, Park CK, Kim JW, Kim YK, Kim SJ
- KMID: 2387703
- Korean J Intern Med.
- 2017 Jul;32(4):589-599.
- doi: 10.3904/kjim.2016.302
A hypoxic microenvironment leads to cancer progression and increases the metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. The hypoxic response pathway can... -
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- Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features
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Kim KJ, Jung HY, Oh MH, Cho H, Lee JH, Lee HJ, Jang SH, Lee MS
- KMID: 2372206
- J Gastric Cancer.
- 2015 Sep;15(3):201-208.
- doi: 10.5230/jgc.2015.15.3.201
PURPOSE: The AT-rich interactive domain 1A (ARID1A) gene encodes BRG1-associated factor 250a, a component of the SWItch/Sucrose NonFermentable chromatin remodeling complex, which is considered a tumor suppressor in many tumors.... -
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