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Perianal Tick-Bite Lesion Caused by a Fully Engorged Female Amblyomma testudinarium

Kim J, Kang HA, Kim SS, Joo HS, Chong WS

A perianal tick and the surrounding skin were surgically excised from a 73-year-old man residing in a southwestern costal area of the Korean Peninsula. Microscopically a deep penetrating lesion was...
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Rooibosâ„¢: Automated schedule broadcast software for clinical pharmacology studies

Lee JH, Chong WS, Park JK, Park TS, Chae SW, Kim MG

Pharmacokinetic blood sampling is a prerequisite for successful early clinical trials. It is essential to take samples at the precise designated times to ensure the reliability of the clinical trial...
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Pharmacokinetic comparison of two valproic acid formulations: a plain and a controlled release enteric-coated tablets

Rha JH, Jang IJ, Lee KH, Chong WS, Shin SG, Lee N, Myung HJ

We investigated the single- and multiple dose pharmacokinetics of a new controlled-release formulation (Orfil retard enteric coated tablet) of valproic acid in comparison with those of the plain tablet as...
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YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity

Chong WS, Kang SY, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC

  • KMID: 1600111
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):283-289.
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced...
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Comparison of inodilator effect of higenamine, YS49, YS51, tetra-hydroisoquinoline analogs, and dobutamine in the rat

Chong WS, Lee YS, Kang YJ, Lee DH, Ryu JC, Yun-Choi H, Chang KC

  • KMID: 1849840
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):323-330.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series...
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Distribution of Genomic Species and Antimicrobial Susceptibility in Acinetobacters Isolated from Gangjin Bay, Korea

Oh JY, Jeong YW, Joo HS, Chong WS, Lee JC, Tamang MD, Lee WB, Park JC

A total of 90 Acinetobacter isolates from freshwater and seawater in Gangjin Bay of Korea was investigated for the distribution of genomic species, antimicrobial resistance patterns and clonal relatedness. By...
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Pharmacological characterization of synthetic tetrahydroisoquinoline alkaloids, YS 51 and YS 55, on the cardiovascular system

Chang KC, Kang YJ, Lee YS, Chong WS, Yun-Choi H, Lee DH, Ryu JC

  • KMID: 2285209
  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):461-469.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions...
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Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury

Chong WS, Hyun CL, Park MK, Park JM, Song HO, Park T, Lim YS, Cho CK, Kang PS, Kwon HU

BACKGROUND: Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as...
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