- Effects of ageing and arthritic disease on nitric oxide production by human articular chondrocytes
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Min BH, Kim HJ, Lim HJ, Park CS, Park SR
- KMID: 1457545
- Exp Mol Med.
- 2001 Dec;33(4):299-302.
Nitric oxide (NO) has been considered as an important mediator in inflammatory phases and in loss of cartilage. In inflammatory arthritis, NO levels are correlated with disease activity and articular... -
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- The Modulation of Integrin Expression by the Extracellular Matrix in Articular Chondrocytes
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Kim SJ, Kim EJ, Kim YH, Hahn SB, Lee JW
- KMID: 720880
- Yonsei Med J.
- 2003 Jun;44(3):493-501.
- doi: 10.3349/ymj.2003.44.3.493
Normal articular cartilage is composed of chondrocytes embedded within an extracellular matrix (ECM). The patterns of integrin expression determine the adhesive properties of cells by modulating interactions with specific ECMs.... -
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- 15-Deoxy-delta 12,14-ProstaglandinJ2 Regulates Dedifferentiation through Peroxisome Proliferator-Activated Receptor-gamma-Dependent Pathway but Not COX-2 Expression in Articular Chondrocytes
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Lee JH, Yu SM, Yoon EK, Lee WK, Jung JC, Kim SJ
- KMID: 1713299
- J Korean Med Sci.
- 2007 Oct;22(5):891-897.
- doi: 10.3346/jkms.2007.22.5.891
Peroxisome proliferator-activated receptors-gamma (PPAR-gamma) is critical for phenotype determination at early differentiation stages of mesenchymal cells, whereas its physiological role is unclear. Therefore, we investigated the role of 15-deoxy-delta 12,14-prostaglandinJ2... -
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- miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
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Makki MS, Haqqi TM
- KMID: 2160620
- Exp Mol Med.
- 2015 Oct;47(10):e189.
- doi: 10.1038/emm.2015.66
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of... -
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- MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes
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Zhang Y, Jia J, Yang S, Liu X, Ye S, Tian H
- KMID: 2155344
- Exp Mol Med.
- 2014 Feb;46(2):e79.
- doi: 10.1038/emm.2013.152
Osteoarthritis is a common cause of functional deterioration in older adults and is an immense burden on the aging population. Altered chondrogenesis is the most important pathophysiological process involved in... -
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- Altered Synthesis of Cartilage-Specific Proteoglycans by Mutant Human Cartilage Oligomeric Matrix Protein
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Kwak YH, Roh JY, Lee KS, Park HW, Kim HW
- KMID: 999399
- Clin Orthop Surg.
- 2009 Dec;1(4):181-187.
- doi: 10.4055/cios.2009.1.4.181
BACKGROUND: The mechanism by which mutant cartilage oligomeric matrix protein (COMP) induces a pseudoachondroplasia phenotype remains unknown, and the reason why a mutation of a minor protein of the growth... -
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- Expression patterns of beta ig-h3 in chondrocyte differentiation during endochondral ossification
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Han MS, Kim JE, Shin HI, Kim IS
- KMID: 1094125
- Exp Mol Med.
- 2008 Aug;40(4):453-460.
- doi: 10.3858/emm.2008.40.4.453
beta ig-h3 is a TGF-beta-induced extracellular matrix protein which is expressed in many tissues including bones and cartilages. In previous reports, we showed that beta ig-h3 mediates cell adhesion and... -
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