- Mechanical Hyperalgesia Induced by Blocking Calcium-activated Potassium Channels on Capsaicin-sensitive Afferent Fiber
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Lee KH, Shin HK
- KMID: 2285345
- Korean J Physiol Pharmacol.
- 2007 Oct;11(5):215-219.
Small and large conductance Ca2+-activated K+ (SKCa and BKCa) channels are implicated in the modulation of neuronal excitability. We investigated how changes in peripheral KCa channel activity affect mechanical sensitivity... -
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- Physiologic Role of K+ Channels in Relaxation of Rabbit Corpus Cavernosal Tissue
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Lee SI, Lee SW
- KMID: 1894493
- Korean J Androl.
- 2002 Dec;20(3):137-142.
PURPOSE: Ion channels play key roles in determining smooth muscle tone by setting the membrane potential and allowing Ca2+ influx. Potassium channels may be important in modulating corporal smooth muscle... -
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- Enhancement of ATP-induced Currents by Phospholipase D1 Overexpressed in PC12 Cells
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Park JB, Kim YR, Jeon BH, Park SK, Oh SO, Kim YG, Lee SD, Kim KJ
- KMID: 2285291
- Korean J Physiol Pharmacol.
- 2003 Aug;7(4):223-230.
Using phospholipase D1 (PLD1) -overexpressing PC12 (PLD1-PC12) cells, the regulatory roles of PLD1 on ATP-induced currents were investigated. In control and PLD1-PC12 cells, ATP increased PLD activity in an external... -
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- Ryanodine Receptor-mediated Calcium Release Regulates Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons
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Park A, Chun SW
- KMID: 2133226
- Int J Oral Biol.
- 2015 Dec;40(4):211-216.
- doi: 10.11620/IJOB.2015.40.4.211
Nitric Oxide (NO) is an important signaling molecule in the nociceptive process. Our previous study suggested that high concentrations of sodium nitroprusside (SNP), a NO donor, induce a membrane hyperpolarization... -
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- External pH effects on delayed rectifier K+ currents of small dorsal root ganglion neuron of rat
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Kim YH, Jung H, Lim IJ, Chung S, Bang HW
- KMID: 1562317
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):165-172.
Under certain pathophysiological conditions, such as inflammation and ischemia, the concentration of H+ ion in the tissue surrounding neurons is changed. Variations in H+ concentration are known to alter the conduction and/of the... -
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- Role of gap junctions in the endothelium-dependent hyperpolarization of vascular smooth muscle cells
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Yamamoto Y, Klemm MF, Hashitani , Lang JR, Soji T, Suzuki H
- KMID: 1606832
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):1-8.
Hyperpolarization of arterial smooth muscle by acetylcholine is considered to be produced by the release of an unidentified chemical substance, an endothelium-derived hyperpolarizing factor (EDHF). Several chemicals have been proposed as the candidate... -
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- Pharmacological evidence that cromakalim inhibits Ca2+ release from intracellular stores in porcine coronary artery
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Rhim BY, Hong SH, Kim CD, Lee WS, Hong KW
- KMID: 2285155
- Korean J Physiol Pharmacol.
- 1997 Feb;1(1):27-34.
In the present study, it was aimed to further identify the intracellular action mechanism of cromakalim and levcromakaliin in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine... -
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- Roles of Ca2+ activated K+ conductances on spontaneous firing patterns of isolated rat medial vestibular nucleus neurons
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Chun SW, Jun JW, Park BR
- KMID: 1580629
- Korean J Physiol Pharmacol.
- 2000 Feb;4(1):1-8.
To investigate the contributions of intrinsic membrane properties to the spontaneous activity of medial vestibular nucleus (MVN) neurons, we assessed the effects of blocking large and small calcium-activated potassium channels by means of... -
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- Possible Involvement of Ca2+ Activated K+ Channels, SK Channel, in the Quercetin-Induced Vasodilatation
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Nishida S, Satoh H
- KMID: 1982569
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):361-365.
- doi: 10.4196/kjpp.2009.13.5.361
Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca2+ activated K+ (KCa)... -
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- Alteration of 4-aminopyridine-sensitive, voltage-dependent K+-channel in arterial smooth muscle cells of one-kidney, one-clip Goldblatt hypertensive rats
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Kim HS, Kim SH, Jeon BH, Chang SJ
- KMID: 1580936
- Korean J Physiol Pharmacol.
- 2000 Oct;4(5):385-391.
Using the patch-clamp technique, we investigated the alteration of 4-aminopyridine(4-AP)-sensitive, voltage-dependent K+ channel (KV) in the mesenteric arterial smooth muscle cell (MASMC) of renovascular hypertensive model, one-kidney one-clip Goldblatt hypertensive rat (GBH). To isolate... -
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- 4-Aminopyridine Inhibits the Large-conductance Ca2+ -activated K+ Channel (BKCa) Currents in Rabbit Pulmonary Arterial Smooth Muscle Cells
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Bae YM, Kim A, Kim B, Cho SI, Kim J, Earm YE
- KMID: 1607350
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):25-28.
Ion channel inhibitors are widely used for pharmacological discrimination between the different channel types as well as for determination of their functional role. In the present study, we tested the... -
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- Decreased voltage dependent K+ currents in cerebral arterial smooth muscle cells of one-kidney, one-clip Goldblatt hypertensive rat
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Oh YS, Kim SH, Kim HS, Jeon BH, Chang SJ, Kim KJ
- KMID: 2071548
- Korean J Physiol Pharmacol.
- 1999 Oct;3(5):471-479.
The Kv channel activity in vascular smooth muscle cell plays an important role in the regulation of membrane potential and blood vessel tone. It was postulated that increased blood vessel tone in hypertension... -
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- Effects of PCLS-2 in Regulation of Rabbit Corpus Cavernosum Smooth Muscle Tone
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Park JK, Kim JU, Cho KW, Lee SK, Kim YC, Lee HS
- KMID: 2292366
- Korean J Urol.
- 2001 Feb;42(2):159-165.
PURPOSE: Relaxation of the penile cavernosum smooth muscle is a critical event in erection. Artemisia iwaymogi(AI) is a perennial herb growing in Korea. The aerial parts have been used in... -
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- The Role of K+Channels in Rabbit Cavernous Smooth Muscle Relaxation by Acetylcholine and Nitroprusside
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Jung GW, Suh JD, Yoon JB
- KMID: 1913900
- Korean J Urol.
- 1995 Jul;36(7):692-703.
It is well known that nitric oxide (NO) mediates smooth muscle relaxation via an increase in cyclic GMP (cGMP) 1evels. Acetylcholine (ACh) and nitroprusside (SNP) are known to mediate relaxation... -
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